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DHFR: dihydrofolate reductase

1 protein, 177 patents, 9 drugs, 2,071 trials, 5,227 NIH grants and 11,671 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDHFRHGNC
Namedihydrofolate reductaseHGNC
NCBI Gene ID1719NCBI Gene
HGNC IDHGNC:2861HGNC
EnsemblENSG00000228716NCBI Gene
AliasesDHFR1, DYRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00374Dihydrofolate reductase18789Ensembl, GeneID, HGNCUniProt

Patents 177

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4795155 A12026-08-261181P00374Espacenet
US 12624353 B22026-05-12496P00374Espacenet
US 12624354 B22026-05-12496P00374Espacenet
JP 2026062659 A2026-04-10496P00374Espacenet
US 12570972 B22026-03-10496P00374Espacenet
JP 2026004568 A2026-01-1443769P00374Espacenet
JP 2026004568 A2026-01-1443770P00374Espacenet
US 12509680 B22025-12-30496P00374Espacenet
JP 2025185029 A2025-12-182P00374Espacenet
US 12460199 B22025-11-0483P00374Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
METHOTREXATECHEMBL34259Dihydrofolate reductase inhibitorINHIBITORChEMBL
METHOTREXATE SODIUMCHEMBL3244648Dihydrofolate reductase inhibitorINHIBITORChEMBL
PEMETREXEDCHEMBL225072Dihydrofolate reductase inhibitorINHIBITORChEMBL
PEMETREXED DIPOTASSIUMCHEMBL6068329Dihydrofolate reductase inhibitorINHIBITORChEMBL
PEMETREXED DISODIUMCHEMBL2360464Dihydrofolate reductase inhibitorINHIBITORChEMBL
PEMETREXED MONOHYDRATECHEMBL5315053Dihydrofolate reductase inhibitorINHIBITORChEMBL
PEMETREXED TROMETHAMINECHEMBL3989962Dihydrofolate reductase inhibitorINHIBITORChEMBL
PIRITREXIMCHEMBL7492Dihydrofolate reductase inhibitorINHIBITORChEMBL
PRALATREXATECHEMBL1201746Dihydrofolate reductase inhibitorINHIBITORChEMBL

Trials 2071

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604987METHOTREXATEPHASE2ClinicalTrials.gov
NCT07586202PEMETREXEDPHASE2ClinicalTrials.gov
NCT07581418METHOTREXATEClinicalTrials.gov
NCT07560826METHOTREXATEPHASE2ClinicalTrials.gov
NCT07559097METHOTREXATEPHASE1/PHASE2ClinicalTrials.gov
NCT07554859PEMETREXEDPHASE2ClinicalTrials.gov
NCT07551778PEMETREXEDPHASE1/PHASE2ClinicalTrials.gov
NCT07551414PEMETREXEDPHASE2ClinicalTrials.gov
NCT07543640METHOTREXATEPHASE2ClinicalTrials.gov
NCT07538193PEMETREXEDClinicalTrials.gov

NIH grants 5227

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA021765Cancer Center Support Grant (CCSG)522,025NIH's project files
P30CA008748Cancer Center Support Grant422,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant422,025NIH's project files
R37AI050234Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance332,025NIH's project files
R01AI109023Defining P. falciparum resistance to artemisinin-based combination therapies222,025NIH's project files
P30CA016672Cancer Center Support Grant202,025NIH's project files
R01AI124678Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparum182,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT132,025NIH's project files
T32CA009531Training Program in the Biology of Cancer132,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology122,025NIH's project files

Papers 11671

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42795000PubTator, text miningPubMed
42780563PubTator, text miningPubMed
42775887PubTator, text miningPubMed
42753477PubTator, text miningPubMed
42743940PubTator, text miningPubMed
42739064PubTator, text miningPubMed
42700206PubTator, text miningPubMed
42674378PubTator, text miningPubMed
42645181PubTator, text miningPubMed
42623030PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license