Gene · 1725
DHPS: deoxyhypusine synthase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DHPS: deoxyhypusine synthase. Genes, record 1725. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1725
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49366 | Deoxyhypusine synthase | 369 | 89 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 43604 | P49366 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 247 | P49366 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 247 | P49366 | Espacenet |
| EP 4551709 A2 | 2025-05-14 | 57 | P49366 | Espacenet |
| JP 2025038035 A | 2025-03-18 | 4479 | P49366 | Espacenet |
| US 12134655 B2 | 2024-11-05 | 4479 | P49366 | Espacenet |
| US 11782061 B2 | 2023-10-10 | 1 | P49366 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 23869 | P49366 | Espacenet |
| KR 1020220123323 A | 2022-09-06 | 1 | P49366 | Espacenet |
| JP 2022530667 A | 2022-06-30 | 4479 | P49366 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants679
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DHPS papers | Newest fiscal year |
|---|---|---|---|
| R01DK060581 | Transcriptional and Translational Mechanisms Governing Beta Cell Function | 18 | 2025 |
| R01AI109023 | Defining P. falciparum resistance to artemisinin-based combination therapies | 7 | 2025 |
| R01DK124906 | Polyamines and Hypusine in Type 1 Diabetes Pathogenesis | 7 | 2025 |
| I01CX002171 | "Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease Progression" | 6 | 2025 |
| K24AI134990 | Mentoring in Translational Malaria Genomics | 6 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30DK020595 | Diabetes Research and Training Center | 6 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 6 | 2025 |
| P30DK097512 | Indiana Diabetes Research Center | 6 | 2025 |
1 to 10 of 679Source NIH's project files
See all 679 nih grantsPapers1,523
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Bactericidal Activity of Eugenol-Rich Syzygium aromaticum Essential Oil Against Multidrug-Resistant Bacteria Isolated from Commercial Eggs. | Pathogens | 2026 | 42796678 | PubTator, text mining | PubMed |
| The hypusine circuit: eIF5A at the crossroads of polyamine metabolism, malignant progression, and therapeutic vulnerability. | Biochim Biophys Acta Rev Cancer | 2026 | 42604705 | PubTator, text mining | PubMed |
Effect of sulphadoxine-pyrimethamine resistance on birthweight and parasite persistence among women receiving intermittent preventive treatment for malaria in pregnancy in Northern Uganda: a directed acyclic graph-guided analysis. | Clin Microbiol Infect | 2026 | 42595091 | PubTator, text mining | PubMed |
| Protocol for proteomic profiling of hypusinated protein candidates using a clickable spermidine probe. | STAR Protoc | 2026 | 42574220 | PubTator, text mining | PubMed |
| Targeting eIF5A2 hypusination with bikinin sensitizes hepatocellular carcinoma to lenvatinib by suppressing TFEB-mediated autophagy. | Hum Cell | 2026 | 42469533 | PubTator, text mining | PubMed |
| Metabolomics reveals potentiated metabolic perturbations induced by antimalarial drug combinations against Plasmodium falciparum in vitro. | Exp Parasitol | 2026 | 42468680 | PubTator, text mining | PubMed |
| Design, synthesis, biological assessment, and integrated computational analysis of new pyrazole-based antimicrobial candidates. | Sci Rep | 2026 | 42432042 | PubTator, text mining | PubMed |
| Drug resistance gene polymorphisms of Plasmodium falciparum clinical isolates from Kinshasa, Democratic Republic of the Congo. | Trop Med Health | 2026 | 42415199 | PubTator, text mining | PubMed |
| Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease. | Arterioscler Thromb Vasc Biol | 2026 | 42389790 | PubTator, text mining | PubMed |
| Temporal trends in artemisinin partial resistance and other antimalarial drug mutations in Plasmodium falciparum from Kagera region, Northwestern Tanzania, 2021-2023. | Front Genet | 2026 | 42311757 | PubTator, text mining | PubMed |
1 to 10 of 1,523
See all 1,523 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1725
GET https://conductscience.org/api/genes/v1/1725/patents?page=2