ConductScience.org, home

Gene · 1725

DHPS: deoxyhypusine synthase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. DHPS: deoxyhypusine synthase. Genes, record 1725. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1725

On this page

Gene

Symbol
DHPS
HGNC
Name
deoxyhypusine synthase
HGNC
NCBI Gene ID
1725
NCBI Gene
HGNC ID
HGNC:2869
HGNC
Ensembl
ENSG00000095059
NCBI Gene
Aliases
DHS, DS, MIG13, NEDSSWI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49366Deoxyhypusine synthase36989Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443604P49366Espacenet
EP 4650780 A22025-11-19247P49366Espacenet
JP 2025517970 A2025-06-12247P49366Espacenet
EP 4551709 A22025-05-1457P49366Espacenet
JP 2025038035 A2025-03-184479P49366Espacenet
US 12134655 B22024-11-054479P49366Espacenet
US 11782061 B22023-10-101P49366Espacenet
US 11446398 B22022-09-2023869P49366Espacenet
KR 1020220123323 A2022-09-061P49366Espacenet
JP 2022530667 A2022-06-304479P49366Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants679

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDHPS papersNewest fiscal year
R01DK060581Transcriptional and Translational Mechanisms Governing Beta Cell Function182025
R01AI109023Defining P. falciparum resistance to artemisinin-based combination therapies72025
R01DK124906Polyamines and Hypusine in Type 1 Diabetes Pathogenesis72025
I01CX002171"Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease Progression"62025
K24AI134990Mentoring in Translational Malaria Genomics62025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer62025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30DK020595Diabetes Research and Training Center62025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025
P30DK097512Indiana Diabetes Research Center62025

1 to 10 of 679Source NIH's project files

See all 679 nih grants

Papers1,523

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bactericidal Activity of Eugenol-Rich Syzygium aromaticum Essential Oil Against Multidrug-Resistant Bacteria Isolated from Commercial Eggs.Pathogens202642796678PubTator, text miningPubMed
The hypusine circuit: eIF5A at the crossroads of polyamine metabolism, malignant progression, and therapeutic vulnerability.Biochim Biophys Acta Rev Cancer202642604705PubTator, text miningPubMed
Effect of sulphadoxine-pyrimethamine resistance on birthweight and parasite persistence among women receiving intermittent preventive treatment for malaria in pregnancy in Northern Uganda: a directed acyclic graph-guided analysis.
Clin Microbiol Infect202642595091PubTator, text miningPubMed
Protocol for proteomic profiling of hypusinated protein candidates using a clickable spermidine probe.STAR Protoc202642574220PubTator, text miningPubMed
Targeting eIF5A2 hypusination with bikinin sensitizes hepatocellular carcinoma to lenvatinib by suppressing TFEB-mediated autophagy.Hum Cell202642469533PubTator, text miningPubMed
Metabolomics reveals potentiated metabolic perturbations induced by antimalarial drug combinations against Plasmodium falciparum in vitro.Exp Parasitol202642468680PubTator, text miningPubMed
Design, synthesis, biological assessment, and integrated computational analysis of new pyrazole-based antimicrobial candidates.Sci Rep202642432042PubTator, text miningPubMed
Drug resistance gene polymorphisms of Plasmodium falciparum clinical isolates from Kinshasa, Democratic Republic of the Congo.Trop Med Health202642415199PubTator, text miningPubMed
Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.Arterioscler Thromb Vasc Biol202642389790PubTator, text miningPubMed
Temporal trends in artemisinin partial resistance and other antimalarial drug mutations in Plasmodium falciparum from Kagera region, Northwestern Tanzania, 2021-2023.Front Genet202642311757PubTator, text miningPubMed

1 to 10 of 1,523

See all 1,523 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1725

GET https://conductscience.org/api/genes/v1/1725/patents?page=2