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NQO1: NAD(P)H quinone dehydrogenase 1

1 protein, 53 patents, 1 drug, 17 trials, 4,295 NIH grants and 12,729 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNQO1HGNC
NameNAD(P)H quinone dehydrogenase 1HGNC
NCBI Gene ID1728NCBI Gene
HGNC IDHGNC:2874HGNC
EnsemblENSG00000181019NCBI Gene
AliasesDHQU, DIA4, DTD, NMOR1, NMORI, QR1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P15559NAD(P)H dehydrogenase [quinone] 127429Ensembl, GeneID, HGNCUniProt

Patents 53

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454901P15559Espacenet
EP 4650780 A22025-11-195271P15559Espacenet
EP 4641202 A22025-10-294933P15559Espacenet
JP 2025517970 A2025-06-125271P15559Espacenet
JP 2025081326 A2025-05-2748P15559Espacenet
KR 1020250017231 A2025-02-044933P15559Espacenet
US 11446398 B22022-09-2054987P15559Espacenet
JP 2022524081 A2022-04-27157958P15559Espacenet
US 11078247 B22021-08-037648P15559Espacenet
US 11066709 B22021-07-2048P15559Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
VATIQUINONECHEMBL1812161Quinone reductase 1 modulatorMODULATORChEMBL

Trials 17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05515536VATIQUINONEPHASE3ClinicalTrials.gov
NCT05485987VATIQUINONEPHASE2ClinicalTrials.gov
NCT05218655VATIQUINONEPHASE32025-12-22ClinicalTrials.gov
NCT04577352VATIQUINONEPHASE2/PHASE3ClinicalTrials.gov
NCT04378075VATIQUINONEPHASE2/PHASE3ClinicalTrials.gov
NCT02352896VATIQUINONEPHASE2ClinicalTrials.gov
NCT02300753VATIQUINONEClinicalTrials.gov
NCT02226458VATIQUINONEPHASE2ClinicalTrials.gov
NCT02104336VATIQUINONEPHASE2ClinicalTrials.gov
NCT01962363VATIQUINONEPHASE2ClinicalTrials.gov

NIH grants 4295

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30ES006694Southwest Environmental Health Sciences Center642,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)462,025NIH's project files
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center372,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology342,025NIH's project files
T32ES007091Training in Environmental Toxicology of Human Disease312,025NIH's project files
P30CA016672Cancer Center Support Grant292,025NIH's project files
P42ES004705Toxic substances in the environment232,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant212,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant192,025NIH's project files
P30CA006973Regional Oncology Research Center152,025NIH's project files

Papers 12729

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825885PubTator, text miningPubMed
42808321PubTator, text miningPubMed
42805912PubTator, text miningPubMed
42796597PubTator, text miningPubMed
42794004PubTator, text miningPubMed
42792158PubTator, text miningPubMed
42792128PubTator, text miningPubMed
42789549PubTator, text miningPubMed
42788794PubTator, text miningPubMed
42787831PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license