Gene · 1734
DIO2: iodothyronine deiodinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DIO2: iodothyronine deiodinase 2. Genes, record 1734. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1734
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92813 | Type II iodothyronine deiodinase | 273 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents6
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 43524 | Q92813 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 43529 | Q92813 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1263 | Q92813 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6179 | Q92813 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1263 | Q92813 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6179 | Q92813 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants977
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DIO2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK077148 | Metabolic and xenobiotic control of thyroid hormone metabolism | 14 | 2025 |
| P30DK036836 | Diabetes Research Center | 11 | 2025 |
| T32DK007529 | Training Grant in Academic Endocrinology | 8 | 2025 |
| P30DK072476 | Pennington/Louisiana NORC | 6 | 2025 |
| R01DK015070 | Thyroid Physiology Studies of Inherited Disorders | 6 | 2025 |
| R01DK128390 | Selenium metabolism in cold-induced adaptive thermogenesis | 6 | 2025 |
| ZIADK075112 | The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in Metabolism | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R01DK082659 | Developmental genes, miRNAs and adipose tissue | 5 | 2025 |
| R01DK095908 | Transgenerational epigenetic programming of the thyroid axis | 5 | 2025 |
1 to 10 of 977Source NIH's project files
See all 977 nih grantsPapers2,006
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Effects of monochromatic light on thyroid hormone and endoplasmic reticulum stress-related signaling in broilers. | Poult Sci | 2026 | 42777370 | PubTator, text mining | PubMed |
| Selenium and selenoproteins in age-related metabolic diseases: mechanistic insights and translational perspectives. | Front Nutr | 2026 | 42713210 | PubTator, text mining | PubMed |
| FAM153A Is a Novel Biomarker of Human Thermogenic Adipocytes. | Cells | 2026 | 42587731 | PubTator, text mining | PubMed |
| Multiomics integrative bioinformatics analysis of gene expression characteristics and molecular mechanisms in preeclampsia placental tissue. | Artif Cells Nanomed Biotechnol | 2026 | 42473750 | PubTator, text mining | PubMed |
| Rudolf Buchheim Award 2026: Regulation of thyroid hormone gatekeepers by thyrotropin in tanycytes. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42414693 | PubTator, text mining | PubMed |
| The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese. | Anim Reprod Sci | 2026 | 42287886 | PubTator, text mining | PubMed |
| Effect of monochromatic light combinations on muscle fiber types in broilers after thyroidectomy. | Poult Sci | 2026 | 42184629 | PubTator, text mining | PubMed |
| Third-trimester estradiol is associated with isolated maternal hypothyroxinemia and attenuated TSH-FT4 coupling: evidence from rats and human astrocytes. | Front Endocrinol (Lausanne) | 2026 | 42147109 | PubTator, text mining | PubMed |
| Decidual senescence in recurrent pregnancy loss: forkhead box M1-targeted progesterone treatment. | Reprod Biomed Online | 2026 | 42143847 | PubTator, text mining | PubMed |
| The type 2 deiodinase Thr92Ala polymorphism and cognitive aging: current evidence and biological context. | Ther Adv Endocrinol Metab | 2026 | 42137609 | PubTator, text mining | PubMed |
1 to 10 of 2,006
See all 2,006 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1734
GET https://conductscience.org/api/genes/v1/1734/grants?page=2