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Gene · 1734

DIO2: iodothyronine deiodinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DIO2: iodothyronine deiodinase 2. Genes, record 1734. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1734

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Gene

Symbol
DIO2
HGNC
Name
iodothyronine deiodinase 2
HGNC
NCBI Gene ID
1734
NCBI Gene
HGNC ID
HGNC:2884
HGNC
Ensembl
ENSG00000211448
NCBI Gene
Aliases
5DII, D2, DIOII, SELENOY, SelY, TXDI2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92813Type II iodothyronine deiodinase2730Ensembl, GeneID, HGNC

Source UniProt

Patents6

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443524Q92813Espacenet
JP 2026004568 A2026-01-1443529Q92813Espacenet
JP 2025529142 A2025-09-041263Q92813Espacenet
JP 2025529142 A2025-09-046179Q92813Espacenet
US 12371689 B22025-07-291263Q92813Espacenet
US 12371689 B22025-07-296179Q92813Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants977

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDIO2 papersNewest fiscal year
R01DK077148Metabolic and xenobiotic control of thyroid hormone metabolism142025
P30DK036836Diabetes Research Center112025
T32DK007529Training Grant in Academic Endocrinology82025
P30DK072476Pennington/Louisiana NORC62025
R01DK015070Thyroid Physiology Studies of Inherited Disorders62025
R01DK128390Selenium metabolism in cold-induced adaptive thermogenesis62025
ZIADK075112The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in Metabolism62025
P30CA008748Cancer Center Support Grant52025
R01DK082659Developmental genes, miRNAs and adipose tissue52025
R01DK095908Transgenerational epigenetic programming of the thyroid axis52025

1 to 10 of 977Source NIH's project files

See all 977 nih grants

Papers2,006

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of monochromatic light on thyroid hormone and endoplasmic reticulum stress-related signaling in broilers.Poult Sci202642777370PubTator, text miningPubMed
Selenium and selenoproteins in age-related metabolic diseases: mechanistic insights and translational perspectives.Front Nutr202642713210PubTator, text miningPubMed
FAM153A Is a Novel Biomarker of Human Thermogenic Adipocytes.Cells202642587731PubTator, text miningPubMed
Multiomics integrative bioinformatics analysis of gene expression characteristics and molecular mechanisms in preeclampsia placental tissue.Artif Cells Nanomed Biotechnol202642473750PubTator, text miningPubMed
Rudolf Buchheim Award 2026: Regulation of thyroid hormone gatekeepers by thyrotropin in tanycytes.Naunyn Schmiedebergs Arch Pharmacol202642414693PubTator, text miningPubMed
The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese.Anim Reprod Sci202642287886PubTator, text miningPubMed
Effect of monochromatic light combinations on muscle fiber types in broilers after thyroidectomy.Poult Sci202642184629PubTator, text miningPubMed
Third-trimester estradiol is associated with isolated maternal hypothyroxinemia and attenuated TSH-FT4 coupling: evidence from rats and human astrocytes.Front Endocrinol (Lausanne)202642147109PubTator, text miningPubMed
Decidual senescence in recurrent pregnancy loss: forkhead box M1-targeted progesterone treatment.Reprod Biomed Online202642143847PubTator, text miningPubMed
The type 2 deiodinase Thr92Ala polymorphism and cognitive aging: current evidence and biological context.Ther Adv Endocrinol Metab202642137609PubTator, text miningPubMed

1 to 10 of 2,006

See all 2,006 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1734

GET https://conductscience.org/api/genes/v1/1734/grants?page=2