Gene · 1735
DIO3: iodothyronine deiodinase 3
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. DIO3: iodothyronine deiodinase 3. Genes, record 1735. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1735
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P55073 | Thyroxine 5-deiodinase | 304 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents3
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants812
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DIO3 papers | Newest fiscal year |
|---|---|---|---|
| R01DK095908 | Transgenerational epigenetic programming of the thyroid axis | 15 | 2025 |
| R01DK077148 | Metabolic and xenobiotic control of thyroid hormone metabolism | 7 | 2025 |
| P20GM121301 | Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks | 5 | 2025 |
| U54GM115516 | Northern New England Clinical and Translational Research Network | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 4 | 2025 |
| P42ES010356 | Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation | 3 | 2025 |
| R01DA026472 | PET Imaging of neurochemical transmission in cocaine use disorders | 3 | 2025 |
| R01DK015070 | Thyroid Physiology Studies of Inherited Disorders | 3 | 2025 |
| ZIADK047036 | Functions of thyroid hormone in retinal development | 3 | 2025 |
1 to 10 of 812Source NIH's project files
See all 812 nih grantsPapers1,635
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Transcriptomic and miRNA-Target Pathway Analysis of the DLK1-DIO3 Imprinted microRNA Cluster in Chronic Lymphocytic Leukemia. | Diseases | 2026 | 42783213 | PubTator, text mining | PubMed |
| Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming. | Nat Commun | 2026 | 42686776 | PubTator, text mining | PubMed |
| Rudolf Buchheim Award 2026: Regulation of thyroid hormone gatekeepers by thyrotropin in tanycytes. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42414693 | PubTator, text mining | PubMed |
| Associations between peripheral blood whole-genome DNA methylation and obesity in young Chinese males. | Arch Endocrinol Metab | 2026 | 42284517 | PubTator, text mining | PubMed |
| Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals. | Cells | 2026 | 42274556 | PubTator, text mining | PubMed |
| Prenatal PFAS Exposure in a Twin Pregnancy Cohort: Associations with Thyroid Disruption, Placental Malperfusion, and Fetal Growth Restriction. | Environ Sci Technol | 2026 | 42231109 | PubTator, text mining | PubMed |
| DIO3 associates with sorting nexins and endosomal trafficking networks in ovarian cancer. | Cell Oncol (Dordr) | 2026 | 42231032 | PubTator, text mining | PubMed |
| Effect of monochromatic light combinations on muscle fiber types in broilers after thyroidectomy. | Poult Sci | 2026 | 42184629 | PubTator, text mining | PubMed |
| Allele-specific CRISPR perturbation of the imprinted Dlk1-Dio3 domain reveals regulation of BMP-NOTCH-VEGF signaling in embryonic organogenesis. | Cell Death Differ | 2026 | 42168359 | PubTator, text mining | PubMed |
| Mouse ICSI impairs fertility of male offspring by disruption of fetomaternal tolerance. | Development | 2026 | 42095840 | PubTator, text mining | PubMed |
1 to 10 of 1,635
See all 1,635 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1735
GET https://conductscience.org/api/genes/v1/1735/grants?page=2