Gene · 1737
DLAT: dihydrolipoamide S-acetyltransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DLAT: dihydrolipoamide S-acetyltransferase. Genes, record 1737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1737
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P10515 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | 647 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 371 | P10515 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 43780 | P10515 | Espacenet |
| EP 4670794 A2 | 2025-12-31 | 7 | P10515 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3083 | P10515 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3083 | P10515 | Espacenet |
| JP 2025508740 A | 2025-04-10 | 130 | P10515 | Espacenet |
| EP 4479433 A2 | 2024-12-25 | 130 | P10515 | Espacenet |
| US 12011480 B2 | 2024-06-18 | 7 | P10515 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1058 | P10515 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 370 | P10515 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,136
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DLAT papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 5 | 2025 |
| R01CA140515 | Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras | 4 | 2025 |
| U19AI057229 | Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro | 4 | 2025 |
| R35CA242457 | Making cancer precision medicine real: bottlenecks and opportunities | 3 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 2 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 2 | 2025 |
| P30CA022453 | CANCER CENTER SUPPORT GRANT | 2 | 2025 |
1 to 10 of 1,136Source NIH's project files
See all 1,136 nih grantsPapers2,650
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Development and application of antibody framework region-targeted cross-linking mass spectrometry for epitope screening within patient-derived immune complexes. | J Pharm Biomed Anal | 2027 | 42759225 | PubTator, text mining | PubMed |
| H2S-scavenging bimetallic phenolic network induces metabolic reprogramming to sensitize colorectal cancer to cuproptosis and ferroptosis. | Biomaterials | 2027 | 42731546 | PubTator, text mining | PubMed |
| Roles of cuproptosis in central nervous system tumors: from molecular mechanisms to therapeutic prospects. | Front Cell Dev Biol | 2026 | 42812787 | PubTator, text mining | PubMed |
| AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells. | Adv Sci (Weinh) | 2026 | 42806865 | PubTator, text mining | PubMed |
| Targeting FDX1 with oridonin triggers cuproptosis and inhibits tumor progression in nasopharyngeal carcinoma. | Int J Biochem Cell Biol | 2026 | 42800577 | PubTator, text mining | PubMed |
| Copper-regulated cell death after spinal cord injury: evidence boundaries for non-coding RNA, epigenetics and cuproptosis. | Front Mol Neurosci | 2026 | 42787557 | PubTator, text mining | PubMed |
| KDM4B Maintains Pyruvate Dehydrogenase Complex Expression to Support Mitochondrial Metabolism and Survival in Cancer Cells. | Epigenomes | 2026 | 42782835 | PubTator, text mining | PubMed |
| Cuproptosis: a novel mechanism linking placental metabolic stress to trophoblast injury in preeclampsia. | Front Endocrinol (Lausanne) | 2026 | 42780476 | PubTator, text mining | PubMed |
| Neutrophil extracellular traps delivering lactylated S100a9 aggravate neuronal cuproptosis by regulating Ttr/Commd1/Atp7b axis after traumatic brain injury. | Redox Biol | 2026 | 42767162 | PubTator, text mining | PubMed |
Elesclomol-mediated cuproptosis overcomes cisplatin resistance by restricting epigenetically activated mitochondrial respiration: Novel therapeutic insights into cisplatin-elesclomol combination therapy. | Acta Pharm Sin B | 2026 | 42764935 | PubTator, text mining | PubMed |
1 to 10 of 2,650
See all 2,650 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1737
GET https://conductscience.org/api/genes/v1/1737/patents?page=2