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Gene · 1737

DLAT: dihydrolipoamide S-acetyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DLAT: dihydrolipoamide S-acetyltransferase. Genes, record 1737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1737

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Gene

Symbol
DLAT
HGNC
Name
dihydrolipoamide S-acetyltransferase
HGNC
NCBI Gene ID
1737
NCBI Gene
HGNC ID
HGNC:2896
HGNC
Ensembl
ENSG00000150768
NCBI Gene
Aliases
DLTA, E2, PBC, PDC-E2, PDCE2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10515Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial64713Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21371P10515Espacenet
JP 2026004568 A2026-01-1443780P10515Espacenet
EP 4670794 A22025-12-317P10515Espacenet
EP 4650780 A22025-11-193083P10515Espacenet
JP 2025517970 A2025-06-123083P10515Espacenet
JP 2025508740 A2025-04-10130P10515Espacenet
EP 4479433 A22024-12-25130P10515Espacenet
US 12011480 B22024-06-187P10515Espacenet
US 11860162 B22024-01-021058P10515Espacenet
JP 2023521663 A2023-05-25370P10515Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,136

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDLAT papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA016672Cancer Center Support Grant52025
P30CA093373Cancer Center Support Grant P3052025
R01CA140515Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras42025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro42025
R35CA242457Making cancer precision medicine real: bottlenecks and opportunities32025
P30CA006973Regional Oncology Research Center22025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA022453CANCER CENTER SUPPORT GRANT22025

1 to 10 of 1,136Source NIH's project files

See all 1,136 nih grants

Papers2,650

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Development and application of antibody framework region-targeted cross-linking mass spectrometry for epitope screening within patient-derived immune complexes.J Pharm Biomed Anal202742759225PubTator, text miningPubMed
H2S-scavenging bimetallic phenolic network induces metabolic reprogramming to sensitize colorectal cancer to cuproptosis and ferroptosis.Biomaterials202742731546PubTator, text miningPubMed
Roles of cuproptosis in central nervous system tumors: from molecular mechanisms to therapeutic prospects.Front Cell Dev Biol202642812787PubTator, text miningPubMed
AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells.Adv Sci (Weinh)202642806865PubTator, text miningPubMed
Targeting FDX1 with oridonin triggers cuproptosis and inhibits tumor progression in nasopharyngeal carcinoma.Int J Biochem Cell Biol202642800577PubTator, text miningPubMed
Copper-regulated cell death after spinal cord injury: evidence boundaries for non-coding RNA, epigenetics and cuproptosis.Front Mol Neurosci202642787557PubTator, text miningPubMed
KDM4B Maintains Pyruvate Dehydrogenase Complex Expression to Support Mitochondrial Metabolism and Survival in Cancer Cells.Epigenomes202642782835PubTator, text miningPubMed
Cuproptosis: a novel mechanism linking placental metabolic stress to trophoblast injury in preeclampsia.Front Endocrinol (Lausanne)202642780476PubTator, text miningPubMed
Neutrophil extracellular traps delivering lactylated S100a9 aggravate neuronal cuproptosis by regulating Ttr/Commd1/Atp7b axis after traumatic brain injury.Redox Biol202642767162PubTator, text miningPubMed
Elesclomol-mediated cuproptosis overcomes cisplatin resistance by restricting epigenetically activated mitochondrial respiration: Novel therapeutic insights into cisplatin-elesclomol combination therapy.
Acta Pharm Sin B202642764935PubTator, text miningPubMed

1 to 10 of 2,650

See all 2,650 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1737

GET https://conductscience.org/api/genes/v1/1737/patents?page=2