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Gene · 1746

DLX2: distal-less homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DLX2: distal-less homeobox 2. Genes, record 1746. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1746

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Gene

Symbol
DLX2
HGNC
Name
distal-less homeobox 2
HGNC
NCBI Gene ID
1746
NCBI Gene
HGNC ID
HGNC:2915
HGNC
Ensembl
ENSG00000115844
NCBI Gene
Aliases
TES-1, TES1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07687Homeobox protein DLX-23280Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444037Q07687Espacenet
JP 2025184866 A2025-12-1811Q07687Espacenet
JP 2025184867 A2025-12-1811Q07687Espacenet
JP 2025147176 A2025-10-0614871Q07687Espacenet
JP 2025028160 A2025-02-2814871Q07687Espacenet
KR 1020250010750 A2025-01-2114871Q07687Espacenet
JP 2024109657 A2024-08-1414710Q07687Espacenet
US 11998540 B22024-06-041Q07687Espacenet
JP 2023543360 A2023-10-1321Q07687Espacenet
JP 2023543361 A2023-10-1328Q07687Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,283

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDLX2 papersNewest fiscal year
R01HG003988Functionally Assessing Transcriptional Enhancers In Vivo62025
T32HD007470Predoctoral Training in Developmental Biology62025
I01BX000252Chromatin-based regulation of neural stem cells52025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant42025
R01AA023797Cellular and genomic mechanisms of the impact of ethanol on human neural model42025
R01MH106575Systematic Functional Interpretation of Regulatory Variants in Neuropsychiatric Disorders42025
P30CA008748Cancer Center Support Grant32025
P50CA116201Mayo Clinic Breast Cancer SPORE32025
R01CA228700Epstein-Barr virus LMP1 mediated oncogenicity32025
R01MH124808Genomic and functional characterization of ASD and ID-associated MYT1L mutation32025

1 to 10 of 1,283Source NIH's project files

See all 1,283 nih grants

Papers1,337

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TESERA: Morphologic subtyping and prognostic stratification of hepatocellular carcinoma from H&E whole-slide images.Hepatology202642826064PubTator, text miningPubMed
Directing GABAergic neuronal identity from human iPSCs through developmental patterning.Stem Cell Reports202642785309PubTator, text miningPubMed
The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate.Nat Commun202642754574PubTator, text miningPubMed
Generation of GABAergic Neurons from Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible ASCL1/DLX2 Expression at AAVS1.J Vis Exp202642612101PubTator, text miningPubMed
rs2357322 and rs17726078 Contribute to Breast Cancer Risk by Regulating DLX2 Expression.Breast J202642596720PubTator, text miningPubMed
PTTG1-DLX2 axis drives malignant progression of lung adenocarcinoma by activating the WNT/β-catenin signaling pathway.Transl Cancer Res202642180979PubTator, text miningPubMed
Single-cell multi-omics analysis reveals two molecular subtypes of human male breast cancer with distinct neuroendocrine and immune characteristics.J Adv Res202642144060PubTator, text miningPubMed
CRISPR Screens Reveal Epstein-Barr Virus-activated JunB as a Key Lymphoblastoid B cell Dependency Factor that Represses Cyclin Dependent Kinase Inhibitor P18INK4c.bioRxiv202641959378PubTator, text miningPubMed
Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization.Nat Mater202641807773PubTator, text miningPubMed
Exploring roles of neuroglobin in oxygen homeostasis and neurodevelopment based on human cerebral organoid models.iScience202641797899PubTator, text miningPubMed

1 to 10 of 1,337

See all 1,337 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1746

GET https://conductscience.org/api/genes/v1/1746/patents?page=2