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Gene · 1749

DLX5: distal-less homeobox 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DLX5: distal-less homeobox 5. Genes, record 1749. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1749

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Gene

Symbol
DLX5
HGNC
Name
distal-less homeobox 5
HGNC
NCBI Gene ID
1749
NCBI Gene
HGNC ID
HGNC:2918
HGNC
Ensembl
ENSG00000105880
NCBI Gene
Aliases
SHFM1, SHFM1D
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P56178Homeobox protein DLX-52892Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444042P56178Espacenet
JP 2025147176 A2025-10-0614874P56178Espacenet
JP 2025028160 A2025-02-2814874P56178Espacenet
EP 4504906 A22025-02-122P56178Espacenet
EP 4504907 A22025-02-125P56178Espacenet
KR 1020250010750 A2025-01-2114874P56178Espacenet
KR 1020240169086 A2024-12-025P56178Espacenet
KR 1020240164811 A2024-11-202P56178Espacenet
JP 2024109657 A2024-08-1414713P56178Espacenet
US 12024722 B22024-07-02162P56178Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,185

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDLX5 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase72025
P30CA016672Cancer Center Support Grant52025
P01AG036675Kynurenine accumulation drives loss of muscle and bone function with aging32025
P30CA008748Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
R01DE030630Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their niches32025
R24HD000836Laboratory of Developmental Biology32025
P30AG066509University of Washington Alzheimer's Disease Research Center22025
P30CA016042Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025

1 to 10 of 1,185Source NIH's project files

See all 1,185 nih grants

Papers1,688

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Single-Cell and Spatial Transcriptomic Analysis of Conventional Ameloblastoma.Oral Dis202642478115PubTator, text miningPubMed
CRISPR activation of DLX5 drives neural progenitors to the GnRH cell fate.J Mol Endocrinol202642454502PubTator, text miningPubMed
SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation.Development202642290293PubTator, text miningPubMed
Mouse, Pig, and Human Atherosclerotic Lesions Have Common and Distinct Mesenchymal Cell Populations.Arterioscler Thromb Vasc Biol202642165148PubTator, text miningPubMed
Identification of novel tumor protein 63 variant associated with split-hand/foot malformation and tooth agenesis.Front Med (Lausanne)202642110406PubTator, text miningPubMed
Blood-Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder.Addict Biol202642047220PubTator, text miningPubMed
Evaluating Thiram-Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches.Environ Toxicol202642015622PubTator, text miningPubMed
Single-cell and spatial transcriptomics reveal that the CXCL12-CXCR4 axis drives the immune-desert phenotype in small cell lung cancer by recruiting immunosuppressive CXCR4+ neutrophils and S100A8+ monocytes.
J Immunother Cancer202641991241PubTator, text miningPubMed
Research progress in heterogeneity of dental mesenchymal stem cells.Int J Oral Sci202641932866PubTator, text miningPubMed
Exploring roles of neuroglobin in oxygen homeostasis and neurodevelopment based on human cerebral organoid models.iScience202641797899PubTator, text miningPubMed

1 to 10 of 1,688

See all 1,688 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1749

GET https://conductscience.org/api/genes/v1/1749/patents?page=2