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Gene · 1763

DNA2: DNA replication helicase/nuclease 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DNA2: DNA replication helicase/nuclease 2. Genes, record 1763. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1763

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Gene

Symbol
DNA2
HGNC
Name
DNA replication helicase/nuclease 2
HGNC
NCBI Gene ID
1763
NCBI Gene
HGNC ID
HGNC:2939
HGNC
Ensembl
ENSG00000138346
NCBI Gene
Aliases
DNA2L, KIAA0083, RTS4, hDNA2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51530DNA replication ATP-dependent helicase/nuclease DNA21,0601Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444083P51530Espacenet
EP 4641201 A22025-10-297551P51530Espacenet
EP 4641202 A22025-10-29409P51530Espacenet
JP 2025100656 A2025-07-0314P51530Espacenet
JP 2025517969 A2025-06-127551P51530Espacenet
KR 1020250017231 A2025-02-04409P51530Espacenet
EP 4464338 A22024-11-2085P51530Espacenet
US 12146152 B22024-11-1983P51530Espacenet
JP 2024504002 A2024-01-3085P51530Espacenet
JP 2024502755 A2024-01-2384P51530Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,016

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDNA2 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines372025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability262025
ZIAAG000752Model Genetic Systems to Study DNA Repair202025
ZIAAG000753Fanconi Anemia Pathway162025
P30CA008748Cancer Center Support Grant142025
P30CA016672Cancer Center Support Grant112025
P30CA033572Cancer Center Support Grant112025
R01ES007061Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice112025
R01GM134681The role of DNA damage tolerance pathways in human cells102025
R50CA211397Functional Analysis of Structure Specific Nucleases in Genome Stability and Cancers102025

1 to 10 of 1,016Source NIH's project files

See all 1,016 nih grants

Papers1,643

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Activation of Pol theta-mediated end joining begins during mitotic commitment.bioRxiv202642779575PubTator, text miningPubMed
GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination.Nat Commun202642773178PubTator, text miningPubMed
Fluorescence properties of 9,10-diphenylanthracene-modified DNA hairpins: Influence of salt-induced B-Z transition and thermal fluctuations.Nucleosides Nucleotides Nucleic Acids202642746931PubTator, text miningPubMed
Correction to: Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer.Funct Integr Genomics202642493676PubTator, text miningPubMed
Molecular Mechanisms and Senescence Signatures in Cervical Squamous Cell Carcinoma: Insights from Transcriptomic and Single-cell Analyses.Recent Pat Anticancer Drug Discov202642478650PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
METTL5-mediated rRNA modification controls prostate cancer progression through the IRF7/DNA2 axis and mitophagy regulation.Oncogene202642437825PubTator, text miningPubMed
Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer.Funct Integr Genomics202642307783PubTator, text miningPubMed
Iron: Regulation, redox homeostasis, and ferroptosis in cancer.Ferroptosis Oxid Stress202642099806PubTator, text miningPubMed
Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.Sci Rep202642098349PubTator, text miningPubMed

1 to 10 of 1,643

See all 1,643 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1763

GET https://conductscience.org/api/genes/v1/1763/patents?page=2