Gene · 1763
DNA2: DNA replication helicase/nuclease 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DNA2: DNA replication helicase/nuclease 2. Genes, record 1763. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1763
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51530 | DNA replication ATP-dependent helicase/nuclease DNA2 | 1,060 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44083 | P51530 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7551 | P51530 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 409 | P51530 | Espacenet |
| JP 2025100656 A | 2025-07-03 | 14 | P51530 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7551 | P51530 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 409 | P51530 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 85 | P51530 | Espacenet |
| US 12146152 B2 | 2024-11-19 | 83 | P51530 | Espacenet |
| JP 2024504002 A | 2024-01-30 | 85 | P51530 | Espacenet |
| JP 2024502755 A | 2024-01-23 | 84 | P51530 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,016
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DNA2 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 37 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 26 | 2025 |
| ZIAAG000752 | Model Genetic Systems to Study DNA Repair | 20 | 2025 |
| ZIAAG000753 | Fanconi Anemia Pathway | 16 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 11 | 2025 |
| R01ES007061 | Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice | 11 | 2025 |
| R01GM134681 | The role of DNA damage tolerance pathways in human cells | 10 | 2025 |
| R50CA211397 | Functional Analysis of Structure Specific Nucleases in Genome Stability and Cancers | 10 | 2025 |
1 to 10 of 1,016Source NIH's project files
See all 1,016 nih grantsPapers1,643
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Activation of Pol theta-mediated end joining begins during mitotic commitment. | bioRxiv | 2026 | 42779575 | PubTator, text mining | PubMed |
| GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination. | Nat Commun | 2026 | 42773178 | PubTator, text mining | PubMed |
| Fluorescence properties of 9,10-diphenylanthracene-modified DNA hairpins: Influence of salt-induced B-Z transition and thermal fluctuations. | Nucleosides Nucleotides Nucleic Acids | 2026 | 42746931 | PubTator, text mining | PubMed |
| Correction to: Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer. | Funct Integr Genomics | 2026 | 42493676 | PubTator, text mining | PubMed |
| Molecular Mechanisms and Senescence Signatures in Cervical Squamous Cell Carcinoma: Insights from Transcriptomic and Single-cell Analyses. | Recent Pat Anticancer Drug Discov | 2026 | 42478650 | PubTator, text mining | PubMed |
| CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks. | Nucleic Acids Res | 2026 | 42475683 | PubTator, text mining | PubMed |
| METTL5-mediated rRNA modification controls prostate cancer progression through the IRF7/DNA2 axis and mitophagy regulation. | Oncogene | 2026 | 42437825 | PubTator, text mining | PubMed |
| Multi-omics analysis positions DNA2 at the interface of genome integrity programs and tumor behavior in pan-cancer. | Funct Integr Genomics | 2026 | 42307783 | PubTator, text mining | PubMed |
| Iron: Regulation, redox homeostasis, and ferroptosis in cancer. | Ferroptosis Oxid Stress | 2026 | 42099806 | PubTator, text mining | PubMed |
| Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients. | Sci Rep | 2026 | 42098349 | PubTator, text mining | PubMed |
1 to 10 of 1,643
See all 1,643 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1763
GET https://conductscience.org/api/genes/v1/1763/patents?page=2