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AGER: advanced glycosylation end-product specific receptor

1 protein, 145 patents, 1 drug, 14 trials, 6,331 NIH grants and 15,445 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAGERHGNC
Nameadvanced glycosylation end-product specific receptorHGNC
NCBI Gene ID177NCBI Gene
HGNC IDHGNC:320HGNC
EnsemblENSG00000204305NCBI Gene
AliasesRAGE, SCARJ1, sRAGENCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q15109Advanced glycation end product-specific receptor40433Ensembl, GeneID, HGNCUniProt

Patents 145

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1014Q15109Espacenet
JP 2026004568 A2026-01-1436861Q15109Espacenet
JP 2026004568 A2026-01-1436872Q15109Espacenet
JP 2026004568 A2026-01-1436879Q15109Espacenet
JP 2026004568 A2026-01-1436883Q15109Espacenet
JP 2026004568 A2026-01-1436888Q15109Espacenet
EP 4650780 A22025-11-199571Q15109Espacenet
EP 4640849 A22025-10-291447Q15109Espacenet
EP 4641201 A22025-10-299830Q15109Espacenet
JP 2025534663 A2025-10-171Q15109Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZELIRAGONCHEMBL3989929Advanced glycosylation end product-specific receptor antagonistANTAGONISTChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06831526AZELIRAGONEARLY_PHASE1ClinicalTrials.gov
NCT06724926AZELIRAGONPHASE1ClinicalTrials.gov
NCT05986851AZELIRAGONPHASE2ClinicalTrials.gov
NCT05815485AZELIRAGONPHASE2/PHASE3ClinicalTrials.gov
NCT05773664AZELIRAGONPHASE1ClinicalTrials.gov
NCT05766748AZELIRAGONPHASE1/PHASE2ClinicalTrials.gov
NCT05635734AZELIRAGONPHASE1/PHASE2ClinicalTrials.gov
NCT05256745AZELIRAGONPHASE1/PHASE2ClinicalTrials.gov
NCT03980730AZELIRAGONPHASE22022-01-21ClinicalTrials.gov
NCT02916056AZELIRAGONPHASE32021-06-01ClinicalTrials.gov

NIH grants 6331

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020541NYR-Diabetes Research Center (NYR-DRC)252,025NIH's project files
P01HL131481Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Diseases202,025NIH's project files
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders152,025NIH's project files
P30CA016087Cancer Center Support Grant142,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
P30CA047904Cancer Center Support Grant142,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)122,025NIH's project files
P30DK063491Diabetes Research Center (DRC)122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files
R35GM118182Molecular basis of bioelectronic medicine112,025NIH's project files

Papers 15445

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824924PubTator, text miningPubMed
42823960PubTator, text miningPubMed
42822803PubTator, text miningPubMed
42819184PubTator, text miningPubMed
42818687PubTator, text miningPubMed
42818080PubTator, text miningPubMed
42815190PubTator, text miningPubMed
42810262PubTator, text miningPubMed
42809427PubTator, text miningPubMed
42808173PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license