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Gene · 1778

DYNC1H1: dynein cytoplasmic 1 heavy chain 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DYNC1H1: dynein cytoplasmic 1 heavy chain 1. Genes, record 1778. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1778

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Gene

Symbol
DYNC1H1
HGNC
Name
dynein cytoplasmic 1 heavy chain 1
HGNC
NCBI Gene ID
1778
NCBI Gene
HGNC ID
HGNC:2961
HGNC
Ensembl
ENSG00000197102
NCBI Gene
Aliases
CDCBM13, CMT2O, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14204Cytoplasmic dynein 1 heavy chain 14,64697Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444481Q14204Espacenet
EP 4650780 A22025-11-197317Q14204Espacenet
EP 4641201 A22025-10-297263Q14204Espacenet
JP 2025517969 A2025-06-127263Q14204Espacenet
JP 2025517970 A2025-06-127317Q14204Espacenet
JP 2023551068 A2023-12-06236Q14204Espacenet
JP 2022141755 A2022-09-29111Q14204Espacenet
US 11446398 B22022-09-2026127Q14204Espacenet
JP 2022524081 A2022-04-27129098Q14204Espacenet
US 11078247 B22021-08-033333Q14204Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,266

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDYNC1H1 papersNewest fiscal year
P40OD010440Caenorhabditis Genetics Center92025
P30CA008748Cancer Center Support Grant62025
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders62025
R01MH101221Rare Mutations and Autism Spectrum Disorders52025
R01NS032457Cell Identity Determination in Human Brain: Somatic Mutation and Cell Lineage52025
R35GM141825Mechanisms of microtubule-based transport42025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
R35GM124889Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal archit32025
UL1TR001863Yale Clinical and Translational Science Award32025
P30CA014195Cancer Center Support Grant (CCSG)22025

1 to 10 of 1,266Source NIH's project files

See all 1,266 nih grants

Papers1,564

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Whole-Body Muscle MRI in Non-5q Spinal Muscular Atrophy: Patterns, Genotype Prediction, and Diagnostic Implications.Neurol Genet202642662709PubTator, text miningPubMed
Landscape of parental postzygotic mutations across >11,000 rare disease trios.Am J Hum Genet202642442367PubTator, text miningPubMed
Genetic causes of the lissencephaly spectrum: insights from chromosomal microarray and clinical/whole-exome sequencing.Croat Med J202642286901PubTator, text miningPubMed
An engineered streptavidin condensate platform for chemically inducible control of endogenous proteins in mammalian cells.bioRxiv202642244538PubTator, text miningPubMed
The P3018S disease variant reveals how dynein's trailing motor sets ensemble velocity.bioRxiv202642239374PubTator, text miningPubMed
Development of Predictive Models for NB-UVB Treatment Efficacy and Safety in Psoriasis.Psoriasis (Auckl)202642220473PubTator, text miningPubMed
FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression.Mol Med Rep202642212377PubTator, text miningPubMed
Gene-specific long-term course, neurodevelopmental outcome and quality of life in patients with LIS1/PAFAH1B1-, DCX-, DYNC1H1-, TUBA1A- and TUBG1-related lissencephaly.Orphanet J Rare Dis202642177523PubTator, text miningPubMed
Generation of iPSC line NIMHi033-A from an Indian patient with Autism Spectrum Disorder carrying mutation in DYNC1H1 gene.Stem Cell Res202642056834PubTator, text miningPubMed
Enlarging the phenotypical spectrum of DYNC1H1-related epilepsy.Neurol Sci202642043625PubTator, text miningPubMed

1 to 10 of 1,564

See all 1,564 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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