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DNMT1: DNA methyltransferase 1

1 protein, 36 patents, 2 drugs, 1,212 trials, 9,316 NIH grants and 22,131 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDNMT1HGNC
NameDNA methyltransferase 1HGNC
NCBI Gene ID1786NCBI Gene
HGNC IDHGNC:2976HGNC
EnsemblENSG00000130816NCBI Gene
AliasesADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaINCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P26358DNA (cytosine-5)-methyltransferase 11,61627Ensembl, GeneID, HGNCUniProt

Patents 36

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4698657 A22026-02-25373P26358Espacenet
JP 2026004568 A2026-01-1444052P26358Espacenet
EP 4650780 A22025-11-197004P26358Espacenet
EP 4641201 A22025-10-296879P26358Espacenet
JP 2025147176 A2025-10-0614890P26358Espacenet
JP 2025517969 A2025-06-126879P26358Espacenet
JP 2025517970 A2025-06-127004P26358Espacenet
JP 2025028160 A2025-02-2814890P26358Espacenet
KR 1020250010750 A2025-01-2114890P26358Espacenet
WO 2024256581 A12024-12-1971P26358Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZACITIDINECHEMBL1489DNA (cytosine-5)-methyltransferase 1 inhibitorINHIBITORChEMBL
DECITABINECHEMBL1201129DNA (cytosine-5)-methyltransferase 1 inhibitorINHIBITORChEMBL

Trials 1212

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605949AZACITIDINEPHASE2ClinicalTrials.gov
NCT07598578AZACITIDINEEARLY_PHASE1ClinicalTrials.gov
NCT07583888AZACITIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07581002AZACITIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07575412AZACITIDINEPHASE2ClinicalTrials.gov
NCT07573670AZACITIDINEPHASE2ClinicalTrials.gov
NCT07572695AZACITIDINEClinicalTrials.gov
NCT07562568AZACITIDINEPHASE2ClinicalTrials.gov
NCT07548983AZACITIDINEPHASE1ClinicalTrials.gov
NCT07548710AZACITIDINEPHASE2ClinicalTrials.gov

NIH grants 9316

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant982,025NIH's project files
P30CA016672Cancer Center Support Grant802,025NIH's project files
P30CA006973Regional Oncology Research Center622,025NIH's project files
P30CA016058Cancer Center Support Grant402,025NIH's project files
R01CA178441Combinatorial epigenetic-based prevention of breast cancer342,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant322,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)302,025NIH's project files
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)302,025NIH's project files
P30CA016086Cancer Center Support Grant242,025NIH's project files
P30CA033572Cancer Center Support Grant232,025NIH's project files

Papers 22131

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818397PubTator, text miningPubMed
42818186PubTator, text miningPubMed
42807872PubTator, text miningPubMed
42807845PubTator, text miningPubMed
42796346PubTator, text miningPubMed
42792755PubTator, text miningPubMed
42790422PubTator, text miningPubMed
42789740PubTator, text miningPubMed
42788794PubTator, text miningPubMed
42787072PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license