ConductScience.org, home

Gene · 1787

TRDMT1: tRNA aspartic acid methyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TRDMT1: tRNA aspartic acid methyltransferase 1. Genes, record 1787. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1787

On this page

Gene

Symbol
TRDMT1
HGNC
Name
tRNA aspartic acid methyltransferase 1
HGNC
NCBI Gene ID
1787
NCBI Gene
HGNC ID
HGNC:2977
HGNC
Ensembl
ENSG00000107614
NCBI Gene
Aliases
DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14717tRNA (cytosine(38)-C(5))-methyltransferase3912Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16585O14717Espacenet
JP 2026523341 A2026-07-141036O14717Espacenet
EP 4771137 A12026-07-08600O14717Espacenet
EP 4771157 A12026-07-08600O14717Espacenet
US 12649003 B22026-06-091036O14717Espacenet
JP 2026510339 A2026-04-02600O14717Espacenet
EP 4713451 A22026-03-25600O14717Espacenet
EP 4713452 A22026-03-25600O14717Espacenet
US 12558437 B22026-02-241036O14717Espacenet
EP 4677082 A22026-01-14600O14717Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants718

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRDMT1 papersNewest fiscal year
R01HD092431Sperm tsRNAs/rsRNAs and their RNA modifications in diet-induced epigenetic inheritance42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal32025
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)22025
P20GM103440Nevada IDeA Networks of Biomedical Research Excellence (INBRE)22025
P30CA014599Cancer Center Support Grant22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30ES027792ChicAgo Center for Health and EnvironmenT (CACHET)22025
P50CA126752SPORE in Lymphoma22025

1 to 10 of 718Source NIH's project files

See all 718 nih grants

Papers1,524

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RNA derived from cancer cells as a scaffold for amyloid-β25-35 aggregation: the effect of RNA methylation and rRNA status.Int J Biol Macromol202642785408PubTator, text miningPubMed
Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα.Nat Commun202642706250PubTator, text miningPubMed
TRDMT1 slows lung cancer growth by stabilizing TFRC mRNA and triggering ferroptosis cell death.J Biol Chem202642637077PubTator, text miningPubMed
TRDMT1-mediated mRNA m5C methylation decreases chemotherapy sensitivity by activating homologous recombination-mediated DNA damage repair and IRS2 expression in pancreatic cancer.Cancer Lett202642431391PubTator, text miningPubMed
RNA methylation in cardiovascular remodeling: Molecular mechanisms, biomarkers, and therapeutic strategies.Mol Biol Rep202642084676PubTator, text miningPubMed
Stress granules at the crossroads of retroviral replication and antiviral immunity: mechanisms and therapeutic opportunities.Mol Biol Rep202641931190PubTator, text miningPubMed
Lifestyle Intervention Therapy Modulates Global DNA Methylation and Adipogenic Gene Expression in Severely Obese Hypogonadal Men.Metabolites202641893347PubTator, text miningPubMed
An integrative analysis reveals the mechanism of plastic stabilizers inducing breast cancer.PLoS Comput Biol202641790613PubTator, text miningPubMed
Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases.Epigenetics202641778387PubTator, text miningPubMed
m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis.Int J Genomics202641755884PubTator, text miningPubMed

1 to 10 of 1,524

See all 1,524 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1787

GET https://conductscience.org/api/genes/v1/1787/patents?page=2