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DNMT3A: DNA methyltransferase 3 alpha

1 protein, 91 patents, 2 drugs, 1,212 trials, 7,342 NIH grants and 17,252 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDNMT3AHGNC
NameDNA methyltransferase 3 alphaHGNC
NCBI Gene ID1788NCBI Gene
HGNC IDHGNC:2978HGNC
EnsemblENSG00000119772NCBI Gene
AliasesDNMT3A-3, DNMT3A2, HESJAS, M.HsaIIIA, TBRSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y6K1DNA (cytosine-5)-methyltransferase 3A91243Ensembl, GeneID, HGNCUniProt

Patents 91

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16577Q9Y6K1Espacenet
JP 2026523341 A2026-07-141028Q9Y6K1Espacenet
EP 4771137 A12026-07-08574Q9Y6K1Espacenet
EP 4771157 A12026-07-08574Q9Y6K1Espacenet
US 12649003 B22026-06-091028Q9Y6K1Espacenet
JP 2026510339 A2026-04-02574Q9Y6K1Espacenet
EP 4713451 A22026-03-25574Q9Y6K1Espacenet
EP 4713452 A22026-03-25574Q9Y6K1Espacenet
US 12558437 B22026-02-241028Q9Y6K1Espacenet
EP 4694917 A12026-02-18592Q9Y6K1Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZACITIDINECHEMBL1489DNA (cytosine-5)-methyltransferase 3A inhibitorINHIBITORChEMBL
DECITABINECHEMBL1201129DNA (cytosine-5)-methyltransferase 3A inhibitorINHIBITORChEMBL

Trials 1212

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605949AZACITIDINEPHASE2ClinicalTrials.gov
NCT07598578AZACITIDINEEARLY_PHASE1ClinicalTrials.gov
NCT07583888AZACITIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07581002AZACITIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT07575412AZACITIDINEPHASE2ClinicalTrials.gov
NCT07573670AZACITIDINEPHASE2ClinicalTrials.gov
NCT07572695AZACITIDINEClinicalTrials.gov
NCT07562568AZACITIDINEPHASE2ClinicalTrials.gov
NCT07548983AZACITIDINEPHASE1ClinicalTrials.gov
NCT07548710AZACITIDINEPHASE2ClinicalTrials.gov

NIH grants 7342

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2122,025NIH's project files
P30CA016672Cancer Center Support Grant2002,025NIH's project files
P30CA006973Regional Oncology Research Center482,025NIH's project files
P30CA016058Cancer Center Support Grant482,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant402,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias332,025NIH's project files
P30CA091842Cancer Center Support Grant332,025NIH's project files
R01HL148565Clonal Hematopoiesis in the Women's Health Initiative332,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)302,025NIH's project files
R01CA183252DNMT3A in Development of Hematologic Malignancies302,025NIH's project files

Papers 17252

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823507PubTator, text miningPubMed
42818859PubTator, text miningPubMed
42818292PubTator, text miningPubMed
42817852PubTator, text miningPubMed
42808192PubTator, text miningPubMed
42806052PubTator, text miningPubMed
42806009PubTator, text miningPubMed
42801678PubTator, text miningPubMed
42796004PubTator, text miningPubMed
42794833PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license