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Gene · 1793

DOCK1: dedicator of cytokinesis 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DOCK1: dedicator of cytokinesis 1. Genes, record 1793. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1793

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Gene

Symbol
DOCK1
HGNC
Name
dedicator of cytokinesis 1
HGNC
NCBI Gene ID
1793
NCBI Gene
HGNC ID
HGNC:2987
HGNC
Ensembl
ENSG00000150760
NCBI Gene
Aliases
DOCK180, ced5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14185Dedicator of cytokinesis protein 11,8651Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443449Q14185Espacenet
EP 4650780 A22025-11-193082Q14185Espacenet
EP 4641201 A22025-10-292638Q14185Espacenet
JP 2025517969 A2025-06-122638Q14185Espacenet
JP 2025517970 A2025-06-123082Q14185Espacenet
JP 2025032204 A2025-03-1127422Q14185Espacenet
EP 4461818 A22024-11-1327422Q14185Espacenet
JP 2023058610 A2023-04-2527422Q14185Espacenet
US 11446398 B22022-09-2023361Q14185Espacenet
JP 2022524081 A2022-04-27126332Q14185Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,206

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDOCK1 papersNewest fiscal year
P40OD010440Caenorhabditis Genetics Center72025
P30CA008748Cancer Center Support Grant62025
T32AI007496Interdisciplinary Training Program in Immunology42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA015704Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA044579University of Virginia Cancer Center Support Grant32025
U54OD030167UAB Center for Precision Animal Modeling (CPAM)32025
ZIAAI000916The mechanisms underlying the GPCR-mediated chemotaxis in D. discoideum32025
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 222025

1 to 10 of 1,206Source NIH's project files

See all 1,206 nih grants

Papers1,307

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ANKRD28 interacts with DOCK180 to activate Rac1-STAT3-Myc signaling and sustain stemness of CD34+ leukemia stem cells in acute myeloid leukemia.Mol Cell Biochem202642803869PubTator, text miningPubMed
Macrophage-Targeted Cyclodextrin-Based Metal-Organic Frameworks Restore Redox-Efferocytosis Coupling to Promote Osteochondral Repair in Temporomandibular Joint Osteoarthritis.Adv Healthc Mater202642733189PubTator, text miningPubMed
ELMO1 and Rac1 Signaling in Kidney Disease: Molecular Mechanisms, Context-Dependent Roles, and Therapeutic Potential.Biomedicines202642652043PubTator, text miningPubMed
Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions.Front Bioinform202642626114PubTator, text miningPubMed
Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.Mol Carcinog202642541488PubTator, text miningPubMed
Identification of a prognostic signature based on expression of post-translational modification-related genes in acute myeloid leukemia.Jpn J Clin Oncol202642490412PubTator, text miningPubMed
Discovery and validation of a robust 11-gene prognostic signature via integrative multi-omics profiling in VD-CAG-treated non-M3 AML.Front Oncol202642239881PubTator, text miningPubMed
RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed by multiplexed optogenetics and biosensor imaging.bioRxiv202642182105PubTator, text miningPubMed
Integrin-focal adhesion-cytoskeleton signaling axis variations and genetic susceptibility to SCD-CAD.Forensic Sci Int202642114173PubTator, text miningPubMed
DOCK1 inhibitor Box5 (TFA) suppresses proliferation of AML cell lines and prolongs survival in AML xenograft models.Sci Rep202642108312PubTator, text miningPubMed

1 to 10 of 1,307

See all 1,307 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1793

GET https://conductscience.org/api/genes/v1/1793/patents