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Gene · 1800

DPEP1: dipeptidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DPEP1: dipeptidase 1. Genes, record 1800. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1800

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Gene

Symbol
DPEP1
HGNC
Name
dipeptidase 1
HGNC
NCBI Gene ID
1800
NCBI Gene
HGNC ID
HGNC:3002
HGNC
Ensembl
ENSG00000015413
NCBI Gene
Aliases
MBD1, MDP, RDP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16444Dipeptidase 14112Ensembl, GeneID, HGNC

Source UniProt

Patents131

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443872P16444Espacenet
JP 2026004568 A2026-01-1443873P16444Espacenet
JP 2026004568 A2026-01-1443874P16444Espacenet
EP 4650780 A22025-11-191923P16444Espacenet
EP 4640849 A22025-10-29233P16444Espacenet
EP 4641201 A22025-10-291513P16444Espacenet
JP 2025147176 A2025-10-064406P16444Espacenet
JP 2025147176 A2025-10-064407P16444Espacenet
JP 2025147176 A2025-10-064408P16444Espacenet
JP 2025529142 A2025-09-046204P16444Espacenet

1 to 10 of 131

See all 131 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CILASTATINCHEMBL766Renal dipeptidase inhibitorINHIBITORChEMBL
CILASTATIN SODIUMCHEMBL1201057Renal dipeptidase inhibitorINHIBITORChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07229040CILASTATINPHASE2ClinicalTrials.gov
NCT06847126CILASTATINPHASE3ClinicalTrials.gov
NCT05204368CILASTATINPHASE3ClinicalTrials.gov
NCT04493151CILASTATINPHASE12024-08-07ClinicalTrials.gov
NCT03293485CILASTATINPHASE32019-09-17ClinicalTrials.gov
NCT03230916CILASTATINPHASE12021-12-13ClinicalTrials.gov
NCT01381549CILASTATINPHASE22017-09-08ClinicalTrials.gov
NCT00589693CILASTATINPHASE32012-07-18ClinicalTrials.gov
NCT00236834CILASTATINPHASE3ClinicalTrials.gov

NIH grants672

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDPEP1 papersNewest fiscal year
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital52025
R35CA197570Early to Late Events in Colorectal Neoplasia: Basic Biology to Clinical Implementation52025
P30CA016672Cancer Center Support Grant42025
P30DK063491Diabetes Research Center (DRC)42025
P50CA236733Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer42025
U54CA2334653/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Center42025
T32DK007191Research Training in Digestive Diseases32025
P01HL114501Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers22025
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 222025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 672Source NIH's project files

See all 672 nih grants

Papers1,095

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dipeptidase-1 Contributes to Sepsis-Associated Endothelial Dysfunction via the EGR1/NF-κB Signaling Axis.Int J Gen Med202642761908PubTator, text miningPubMed
DPEP1 promotes pulmonary fibrosis by regulating arachidonic acid metabolism.J Thorac Dis202642724184PubTator, text miningPubMed
Neutrophil-mediated acute kidney injury and its progression to chronicity.iScience202642656978PubTator, text miningPubMed
A Multi-Layered Proteogenomic Framework for the Prioritization of Cell Surface Therapeutic Targets: Proof-of-Concept for Metastatic Colorectal Cancer.Cancers (Basel)202642649884PubTator, text miningPubMed
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.Physiol Int202642640735PubTator, text miningPubMed
A network toxicology and machine learning approach to uncover the molecular machinery of bisphenol A-induced colorectal cancer.Sci Rep202642624872PubTator, text miningPubMed
"Influence of macroretention in polymer-infiltrated ceramic network- and zirconia crowns and different roughness values of titanium bases on adhesive bond strength of hybrid abutment crowns: an in vitro study".
BMC Oral Health202642603786PubTator, text miningPubMed
Kidney-Targeted Cilastatin Nanoparticles Inhibit DPEP1-Mediated Ferroptosis for Acute Kidney Injury Therapy.Adv Sci (Weinh)202642593850PubTator, text miningPubMed
Identification of DNA sequence variants in the Vasculo-Behcet disease patient using whole exome sequencing: a pilot study from Pakistan.Sci Rep202642386946PubTator, text miningPubMed
A DPEP1-Binding and mitochondria-targeted nanocomposite relieves acute respiratory distress syndrome by inhibiting Drp1-mediated mitochondria fission.Mater Today Bio202642256056PubTator, text miningPubMed

1 to 10 of 1,095

See all 1,095 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1800

GET https://conductscience.org/api/genes/v1/1800/patents?page=2