Gene · 1800
DPEP1: dipeptidase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DPEP1: dipeptidase 1. Genes, record 1800. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1800
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16444 | Dipeptidase 1 | 411 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents131
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 43872 | P16444 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 43873 | P16444 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 43874 | P16444 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1923 | P16444 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 233 | P16444 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1513 | P16444 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4406 | P16444 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4407 | P16444 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4408 | P16444 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6204 | P16444 | Espacenet |
1 to 10 of 131
See all 131 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials9
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07229040 | CILASTATIN | PHASE2 | ClinicalTrials.gov | |
| NCT06847126 | CILASTATIN | PHASE3 | ClinicalTrials.gov | |
| NCT05204368 | CILASTATIN | PHASE3 | ClinicalTrials.gov | |
| NCT04493151 | CILASTATIN | PHASE1 | 2024-08-07 | ClinicalTrials.gov |
| NCT03293485 | CILASTATIN | PHASE3 | 2019-09-17 | ClinicalTrials.gov |
| NCT03230916 | CILASTATIN | PHASE1 | 2021-12-13 | ClinicalTrials.gov |
| NCT01381549 | CILASTATIN | PHASE2 | 2017-09-08 | ClinicalTrials.gov |
| NCT00589693 | CILASTATIN | PHASE3 | 2012-07-18 | ClinicalTrials.gov |
| NCT00236834 | CILASTATIN | PHASE3 | ClinicalTrials.gov |
NIH grants672
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DPEP1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 5 | 2025 |
| R35CA197570 | Early to Late Events in Colorectal Neoplasia: Basic Biology to Clinical Implementation | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| P50CA236733 | Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer | 4 | 2025 |
| U54CA233465 | 3/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Center | 4 | 2025 |
| T32DK007191 | Research Training in Digestive Diseases | 3 | 2025 |
| P01HL114501 | Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers | 2 | 2025 |
| P20GM121334 | Mississippi Center of Excellence in Perinatal Research, Phase 2 | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 672Source NIH's project files
See all 672 nih grantsPapers1,095
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dipeptidase-1 Contributes to Sepsis-Associated Endothelial Dysfunction via the EGR1/NF-κB Signaling Axis. | Int J Gen Med | 2026 | 42761908 | PubTator, text mining | PubMed |
| DPEP1 promotes pulmonary fibrosis by regulating arachidonic acid metabolism. | J Thorac Dis | 2026 | 42724184 | PubTator, text mining | PubMed |
| Neutrophil-mediated acute kidney injury and its progression to chronicity. | iScience | 2026 | 42656978 | PubTator, text mining | PubMed |
| A Multi-Layered Proteogenomic Framework for the Prioritization of Cell Surface Therapeutic Targets: Proof-of-Concept for Metastatic Colorectal Cancer. | Cancers (Basel) | 2026 | 42649884 | PubTator, text mining | PubMed |
| Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review. | Physiol Int | 2026 | 42640735 | PubTator, text mining | PubMed |
| A network toxicology and machine learning approach to uncover the molecular machinery of bisphenol A-induced colorectal cancer. | Sci Rep | 2026 | 42624872 | PubTator, text mining | PubMed |
"Influence of macroretention in polymer-infiltrated ceramic network- and zirconia crowns and different roughness values of titanium bases on adhesive bond strength of hybrid abutment crowns: an in vitro study". | BMC Oral Health | 2026 | 42603786 | PubTator, text mining | PubMed |
| Kidney-Targeted Cilastatin Nanoparticles Inhibit DPEP1-Mediated Ferroptosis for Acute Kidney Injury Therapy. | Adv Sci (Weinh) | 2026 | 42593850 | PubTator, text mining | PubMed |
| Identification of DNA sequence variants in the Vasculo-Behcet disease patient using whole exome sequencing: a pilot study from Pakistan. | Sci Rep | 2026 | 42386946 | PubTator, text mining | PubMed |
| A DPEP1-Binding and mitochondria-targeted nanocomposite relieves acute respiratory distress syndrome by inhibiting Drp1-mediated mitochondria fission. | Mater Today Bio | 2026 | 42256056 | PubTator, text mining | PubMed |
1 to 10 of 1,095
See all 1,095 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1800
GET https://conductscience.org/api/genes/v1/1800/patents?page=2