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DPP4: dipeptidyl peptidase 4

1 protein, 255 patents, 23 drugs, 745 trials, 6,254 NIH grants and 23,557 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDPP4HGNC
Namedipeptidyl peptidase 4HGNC
NCBI Gene ID1803NCBI Gene
HGNC IDHGNC:3009HGNC
EnsemblENSG00000197635NCBI Gene
AliasesADABP, ADCP2, CD26, DPPIV, TP103NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P27487Dipeptidyl peptidase 4766117Ensembl, GeneID, HGNCUniProt

Patents 255

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209911 A12026-10-0834P27487Espacenet
WO 2026209914 A12026-10-0834P27487Espacenet
JP 2026130480 A2026-08-131P27487Espacenet
JP 2026062901 A2026-04-102P27487Espacenet
JP 2026508054 A2026-03-1019P27487Espacenet
JP 2026035703 A2026-03-042P27487Espacenet
JP 2025542209 A2025-12-2510P27487Espacenet
EP 4650780 A22025-11-197788P27487Espacenet
JP 2025157475 A2025-10-1564P27487Espacenet
JP 2025147176 A2025-10-064425P27487Espacenet

Drugs 23

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALOGLIPTINCHEMBL376359Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
ALOGLIPTIN BENZOATECHEMBL227529Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
ANAGLIPTINCHEMBL1929396Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
BEGELOMABCHEMBL3833357Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
BISEGLIPTINCHEMBL4297624Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
CARMEGLIPTINCHEMBL591118Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
DBPR-108CHEMBL1082462Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
DUTOGLIPTINCHEMBL4296719Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
EVOGLIPTINCHEMBL1779710Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL
GEMIGLIPTINCHEMBL3707235Dipeptidyl peptidase IV inhibitorINHIBITORChEMBL

Trials 745

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07541781SITAGLIPTINPHASE1ClinicalTrials.gov
NCT07452913SITAGLIPTINPHASE4ClinicalTrials.gov
NCT07452913LINAGLIPTINPHASE4ClinicalTrials.gov
NCT07442006ANAGLIPTINPHASE4ClinicalTrials.gov
NCT07442006LINAGLIPTINPHASE4ClinicalTrials.gov
NCT07417631SITAGLIPTINClinicalTrials.gov
NCT07374328SITAGLIPTINPHASE1/PHASE2ClinicalTrials.gov
NCT07365592SITAGLIPTINPHASE1/PHASE2ClinicalTrials.gov
NCT07289750ALOGLIPTINPHASE4ClinicalTrials.gov
NCT07247656LINAGLIPTINPHASE4ClinicalTrials.gov

NIH grants 6254

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant522,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award322,025NIH's project files
P30DK017047Diabetes Research Center242,025NIH's project files
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)222,025NIH's project files
R01AI129269Olfactory and neurological manifestations of acute and post-acute murine COVID-19222,025NIH's project files
ZIAAI001179Virus Ecology Unit202,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)172,025NIH's project files
P30DK020593Vanderbilt Diabetes Research Center172,025NIH's project files
P30DK026687New York Obesity Research Center162,025NIH's project files

Papers 23557

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823777PubTator, text miningPubMed
42818199PubTator, text miningPubMed
42813062PubTator, text miningPubMed
42811461PubTator, text miningPubMed
42792683PubTator, text miningPubMed
42789549PubTator, text miningPubMed
42784318PubTator, text miningPubMed
42782746PubTator, text miningPubMed
42778221PubTator, text miningPubMed
42775555PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license