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Gene · 1806

DPYD: dihydropyrimidine dehydrogenase

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. DPYD: dihydropyrimidine dehydrogenase. Genes, record 1806. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/1806

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
DPYD
HGNC
Name
dihydropyrimidine dehydrogenase
HGNC
NCBI Gene ID
1806
NCBI Gene
HGNC ID
HGNC:3012
HGNC
Ensembl
ENSG00000188641
NCBI Gene
Aliases
DHP, DHPDHASE, DHPDHase, DPD, DYPD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12882Dihydropyrimidine dehydrogenase [NADP(+)]1,0250Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198740Q12882Espacenet
EP 4640849 A22025-10-291325Q12882Espacenet
EP 4641201 A22025-10-298933Q12882Espacenet
JP 2025147176 A2025-10-0616587Q12882Espacenet
JP 2025519096 A2025-06-241325Q12882Espacenet
JP 2025517969 A2025-06-128933Q12882Espacenet
JP 2025517970 A2025-06-128740Q12882Espacenet
JP 2025032204 A2025-03-1127499Q12882Espacenet
JP 2025028160 A2025-02-2816587Q12882Espacenet
KR 1020250010750 A2025-01-2116587Q12882Espacenet

1 to 10 of 23

See all 23 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ENILURACILCHEMBL355200Dihydropyrimidine dehydrogenase inhibitorINHIBITORChEMBL
GIMERACILCHEMBL1730601Dihydropyrimidine dehydrogenase inhibitorINHIBITORChEMBL

Trials147

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07315854GIMERACILPHASE2ClinicalTrials.gov
NCT07182565GIMERACILPHASE1/PHASE2ClinicalTrials.gov
NCT06761846GIMERACILPHASE2ClinicalTrials.gov
NCT06487702GIMERACILPHASE2ClinicalTrials.gov
NCT06451211GIMERACILPHASE2ClinicalTrials.gov
NCT06385873GIMERACILPHASE2ClinicalTrials.gov
NCT06341595GIMERACILPHASE2ClinicalTrials.gov
NCT06229496GIMERACILPHASE1ClinicalTrials.gov
NCT06196697GIMERACILPHASE2ClinicalTrials.gov
NCT06187597GIMERACILPHASE2ClinicalTrials.gov

1 to 10 of 147

See all 147 trials

NIH grants1,496

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant162025
P30CA016672Cancer Center Support Grant142025
P30CA021765Cancer Center Support Grant (CCSG)82025
P30DK017047Diabetes Research Center82025
P30CA012197Cancer Center Support Grant72025
P30CA014599Cancer Center Support Grant72025
P30CA016056Roswell Park Cancer Center Support Grant72025
R01CA251065A precision medicine approach to improve prediction of severe toxicity in fluorouracil chemotherapy72025
ZIABC010627Clinical Pharmacogenetics72025
P30CA013148Comprehensive Cancer Center Support Grant62025

1 to 10 of 1,496Source NIH's project files

See all 1,496 nih grants

Papers4,420

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820760PubTator, text miningPubMed
42810338PubTator, text miningPubMed
42803377PubTator, text miningPubMed
42792977PubTator, text miningPubMed
42752660PubTator, text miningPubMed
42728745PubTator, text miningPubMed
42727832PubTator, text miningPubMed
42669144PubTator, text miningPubMed
42614302PubTator, text miningPubMed
42608132PubTator, text miningPubMed

1 to 10 of 4,420

See all 4,420 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1806

GET https://conductscience.org/api/genes/v1/1806/patents?page=2