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Gene · 181

AGRP: agouti related neuropeptide

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AGRP: agouti related neuropeptide. Genes, record 181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/181

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Gene

Symbol
AGRP
HGNC
Name
agouti related neuropeptide
HGNC
NCBI Gene ID
181
NCBI Gene
HGNC ID
HGNC:330
HGNC
Ensembl
ENSG00000159723
NCBI Gene
Aliases
AGRT, ART, ASIP2, Agrt
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00253Agouti-related protein1322Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436942O00253Espacenet
EP 4650780 A22025-11-193451O00253Espacenet
WO 2025227129 A22025-10-3014O00253Espacenet
JP 2025147176 A2025-10-06622O00253Espacenet
JP 2025529142 A2025-09-045436O00253Espacenet
US 12371689 B22025-07-295436O00253Espacenet
JP 2025517970 A2025-06-123451O00253Espacenet
JP 2025062604 A2025-04-143642O00253Espacenet
JP 2025028160 A2025-02-28622O00253Espacenet
KR 1020250010750 A2025-01-21622O00253Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,894

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAGRP papersNewest fiscal year
P30DK026687New York Obesity Research Center282025
P30DK020572Michigan Diabetes Research Center (MDRC)192025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)152025
P30DK072476Pennington/Louisiana NORC142025
P30DK017047Diabetes Research Center112025
P30DK045735Yale Diabetes Research Center102025
P30DK035816Nutrition Obesity Research Center92025
P30DK063608Columbia Diabetes Research Center92025
ZIADK075087Probing neural circuits underlying satiety92025
P51OD011092Support for National Primate Research Center82025

1 to 10 of 1,894Source NIH's project files

See all 1,894 nih grants

Papers3,076

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Short-chain fatty acids differentially regulate feed intake and hypothalamic appetite-related genes in layer-type chicks.Front Physiol202642819174PubTator, text miningPubMed
AgRP neurons support GLP-1-induced weight loss.Lab Anim (NY)202642806103PubTator, text miningPubMed
A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv202642780255PubTator, text miningPubMed
Autophagy in hypothalamic POMC and AgRP neurons: mechanisms and therapeutic implications for obesity.Int J Obes (Lond)202642768087PubTator, text miningPubMed
Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis.Nat Commun202642736279PubTator, text miningPubMed
Olink proteomics identifies serum protein biomarkers and an age-stratified diagnostic model for diabetes in Chinese patients.Front Endocrinol (Lausanne)202642718750PubTator, text miningPubMed
Adipose Tissue-Central Nervous System Axis in Obesity: Molecular Mechanisms, Inflammation, and Nutritional and Technological Implications.Metabolites202642646269PubTator, text miningPubMed
Connecting the dots between sleep deprivation and obesity: the role of melatonin in appetite regulation and insulin sensitivity from a mechanistic review perspective.Physiol Behav202642637185PubTator, text miningPubMed
Hunger that runs ahead of the body.Neuron202642617587PubTator, text miningPubMed
Assessment of Brain-Specific and Neuroendocrine Biomarkers for Intracerebral Hemorrhage Diagnosis: A Prospective Cohort Study.Biomark Insights202642542769PubTator, text miningPubMed

1 to 10 of 3,076

See all 3,076 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/181

GET https://conductscience.org/api/genes/v1/181/patents?page=2