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DRD2: dopamine receptor D2

1 protein, 84 patents, 122 drugs, 2,309 trials, 7,939 NIH grants and 16,048 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDRD2HGNC
Namedopamine receptor D2HGNC
NCBI Gene ID1813NCBI Gene
HGNC IDHGNC:3023HGNC
EnsemblENSG00000149295NCBI Gene
AliasesD2DR, D2RNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14416Dopamine receptor D244311Ensembl, GeneID, HGNCUniProt

Patents 84

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-2217P14416Espacenet
JP 2026016502 A2026-02-031P14416Espacenet
JP 2026004568 A2026-01-1444195P14416Espacenet
JP 2026004568 A2026-01-1444198P14416Espacenet
EP 4641201 A22025-10-298050P14416Espacenet
JP 2025534434 A2025-10-15165P14416Espacenet
JP 2025529142 A2025-09-041319P14416Espacenet
US 12371689 B22025-07-291319P14416Espacenet
JP 2025517969 A2025-06-128050P14416Espacenet
JP 2025516139 A2025-05-272P14416Espacenet

Drugs 122

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETOPHENAZINECHEMBL1085Dopamine D2 receptor antagonistANTAGONISTChEMBL
ACETOPHENAZINE MALEATECHEMBL2360079Dopamine D2 receptor antagonistANTAGONISTChEMBL
ADOPRAZINECHEMBL221692Dopamine D2 receptor antagonistANTAGONISTChEMBL
ALIZAPRIDECHEMBL290194Dopamine D2 receptor antagonistANTAGONISTChEMBL
AMINEPTINECHEMBL418995Dopamine D1 and D2 receptor antagonistANTAGONISTChEMBL
AMISULPRIDECHEMBL243712Dopamine receptors; D2 & D3 antagonistANTAGONISTChEMBL
AMOXAPINECHEMBL1113Dopamine receptor antagonistANTAGONISTChEMBL
APLINDORECHEMBL2110659Dopamine D2 receptor partial agonistPARTIAL AGONISTChEMBL
APLINDORE FUMARATECHEMBL2104864Dopamine D2 receptor partial agonistPARTIAL AGONISTChEMBL
APOMORPHINECHEMBL53D2-like dopamine receptor agonistAGONISTChEMBL

Trials 2309

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07575516RISPERIDONEPHASE2ClinicalTrials.gov
NCT07565428ARIPIPRAZOLEPHASE3ClinicalTrials.gov
NCT07565428OLANZAPINEPHASE3ClinicalTrials.gov
NCT07565428RISPERIDONEPHASE3ClinicalTrials.gov
NCT07547384ARIPIPRAZOLEClinicalTrials.gov
NCT07541157RISPERIDONEClinicalTrials.gov
NCT07524868RISPERIDONEClinicalTrials.gov
NCT07523256RISPERIDONEClinicalTrials.gov
NCT07503002RISPERIDONEPHASE1ClinicalTrials.gov
NCT07493551PALIPERIDONE PALMITATEClinicalTrials.gov

NIH grants 7939

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01MH054137Structure and Function of Dopamine Receptors672,025NIH's project files
ZIAAA000550Neurobiology of Drug Reward and Addiction672,025NIH's project files
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS532,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award472,025NIH's project files
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).422,025NIH's project files
ZIANS002263Molecular And Pharmacological Studies Of Dopamine Receptors342,025NIH's project files
ZIAAA000301Integrative genetics of behavior with high throughput technologies292,025NIH's project files
ZIADA000606Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptor262,025NIH's project files
ZIADA000424Novel Dopamine D3/D2 Receptor Ligands232,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism192,025NIH's project files

Papers 16048

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826505PubTator, text miningPubMed
42805551PubTator, text miningPubMed
42801895PubTator, text miningPubMed
42801338PubTator, text miningPubMed
42800225PubTator, text miningPubMed
42798706PubTator, text miningPubMed
42796507PubTator, text miningPubMed
42785810PubTator, text miningPubMed
42780122PubTator, text miningPubMed
42767220PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license