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Gene · 1814

DRD3: dopamine receptor D3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DRD3: dopamine receptor D3. Genes, record 1814. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1814

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Gene

Symbol
DRD3
HGNC
Name
dopamine receptor D3
HGNC
NCBI Gene ID
1814
NCBI Gene
HGNC ID
HGNC:3024
HGNC
Ensembl
ENSG00000151577
NCBI Gene
Aliases
D3DR, ETM1, FET1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35462Dopamine receptor D34007Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444203P35462Espacenet
JP 2026004568 A2026-01-1444204P35462Espacenet
JP 2026004568 A2026-01-1444205P35462Espacenet
EP 4641201 A22025-10-2910980P35462Espacenet
JP 2025517969 A2025-06-1210980P35462Espacenet
US 11446398 B22022-09-2025461P35462Espacenet
US 11446398 B22022-09-2025462P35462Espacenet
US 11446398 B22022-09-2025463P35462Espacenet
US 11400116 B22022-08-02255P35462Espacenet
JP 2022524081 A2022-04-27128432P35462Espacenet

1 to 10 of 24

See all 24 patents

Drugs48

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-925CHEMBL439338Dopamine D3 receptor antagonistANTAGONISTChEMBL
ADOPRAZINECHEMBL221692Dopamine D3 receptor antagonistANTAGONISTChEMBL
AMISULPRIDECHEMBL243712Dopamine receptors; D2 & D3 antagonistANTAGONISTChEMBL
AMOXAPINECHEMBL1113Dopamine receptor antagonistANTAGONISTChEMBL
APOMORPHINECHEMBL53D2-like dopamine receptor agonistAGONISTChEMBL
APOMORPHINE HYDROCHLORIDECHEMBL3187985D2-like dopamine receptor agonistAGONISTChEMBL
BLONANSERINCHEMBL178803Dopamine D3 receptor antagonistANTAGONISTChEMBL
BROMOCRIPTINECHEMBL493D2-like dopamine receptor agonistAGONISTChEMBL
BROMOCRIPTINE MESYLATECHEMBL1200503D2-like dopamine receptor agonistAGONISTChEMBL
CARIPRAZINECHEMBL2028019Dopamine D3 receptor modulatorMODULATORChEMBL

1 to 10 of 48

See all 48 drugs

Trials940

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07565428OLANZAPINEPHASE3ClinicalTrials.gov
NCT07480785DROPERIDOLClinicalTrials.gov
NCT07382960PRAMIPEXOLEClinicalTrials.gov
NCT07263191OLANZAPINEClinicalTrials.gov
NCT07190482OLANZAPINEPHASE1ClinicalTrials.gov
NCT07185815CARIPRAZINEPHASE1/PHASE2ClinicalTrials.gov
NCT07152184LEVOMEPROMAZINEPHASE2ClinicalTrials.gov
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT07152184HALOPERIDOLPHASE2ClinicalTrials.gov
NCT07152184CHLORPROMAZINEPHASE2ClinicalTrials.gov

1 to 10 of 940

See all 940 trials

NIH grants1,692

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDRD3 papersNewest fiscal year
ZIADA000424Novel Dopamine D3/D2 Receptor Ligands152025
ZIANS002263Molecular And Pharmacological Studies Of Dopamine Receptors122025
UL1TR001863Yale Clinical and Translational Science Award102025
ZIAAA000301Integrative genetics of behavior with high throughput technologies102025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).82025
P30MH062512HIV Neurobehavioral Research Center62025
ZIADA000606Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptor62025
R01MH112205Molecular Details of Psychoactive Drug Actions52025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism52025
T32MH079785Interdisciplinary And Translational Research Training In Neurohiv42025

1 to 10 of 1,692Source NIH's project files

See all 1,692 nih grants

Papers2,771

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association.Front Aging Neurosci202642741404PubTator, text miningPubMed
Receptor Contribution Reallocation After Removal of Literature-Derived Weights: A Secondary Sensitivity Analysis of the Integrated Ki-DDD-TWAS Pipeline for Antipsychotic Lipid-Trait Prioritization.Cureus202642540671PubTator, text miningPubMed
Dopaminergic genetic variation and response to social comparative feedback when learning a motor sequence task.PLoS One202642525625PubTator, text miningPubMed
Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism.BMC Oral Health202642237294PubTator, text miningPubMed
Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone.Drug Des Devel Ther202642052100PubTator, text miningPubMed
Repurposing Quetiapine as an Adjuvant Therapeutic Agent for Triple-Negative Breast Cancer.Radiat Res202642019962PubTator, text miningPubMed
Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia.Transl Psychiatry202641922311PubTator, text miningPubMed
Safety and T1 reactivity for vasodilator stress ferumoxytol-enhanced cardiac magnetic resonance imaging.J Cardiovasc Magn Reson202641864344PubTator, text miningPubMed
Polymorphisms in GPCR genes: Their role in schizophrenia, autism diseases and response to antipsychotic treatment - A systematic review.Prog Neuropsychopharmacol Biol Psychiatry202641862122PubTator, text miningPubMed
Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study.Cancer Manag Res202641798904PubTator, text miningPubMed

1 to 10 of 2,771

See all 2,771 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1814

GET https://conductscience.org/api/genes/v1/1814/patents?page=2