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Gene · 1828

DSG1: desmoglein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DSG1: desmoglein 1. Genes, record 1828. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1828

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Gene

Symbol
DSG1
HGNC
Name
desmoglein 1
HGNC
NCBI Gene ID
1828
NCBI Gene
HGNC ID
HGNC:3048
HGNC
Ensembl
ENSG00000134760
NCBI Gene
Aliases
CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02413Desmoglein-11,0490Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443666Q02413Espacenet
JP 2025541179 A2025-12-1829Q02413Espacenet
EP 4650780 A22025-11-191619Q02413Espacenet
EP 4641201 A22025-10-291226Q02413Espacenet
EP 4630459 A12025-10-1529Q02413Espacenet
JP 2025529142 A2025-09-041330Q02413Espacenet
US 12371689 B22025-07-291330Q02413Espacenet
JP 2025517969 A2025-06-121226Q02413Espacenet
JP 2025517970 A2025-06-121619Q02413Espacenet
EP 4518890 A22025-03-12217Q02413Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,141

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDSG1 papersNewest fiscal year
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen532025
U19AI070235Epithelial Genes in Allergic Inflammation322025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease252025
R01AR043380Desmoplakin Assembly and Function in Epidermis212025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center202025
R01AI124355Genetic and Immunological Dissection of Eosinophilic Esophagitis182025
T32AR007465Penn Dermatology Research Training Program132025
R01CA228196Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma122025
T32CA009560Carcinogenesis Training Program112025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center102025

1 to 10 of 1,141Source NIH's project files

See all 1,141 nih grants

Papers3,287

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical improvement of pemphigus-like mucocutaneous disease in a patient with CLL following initiation of zanubrutinib: a case report.Front Immunol202642812523PubTator, text miningPubMed
Coexistence of Erythrodermic Psoriasis and Bullous Pemphigoid: A Case Report.Clin Cosmet Investig Dermatol202642770037PubTator, text miningPubMed
Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial.Br J Dermatol202642723554PubTator, text miningPubMed
Pemphigus Erythematosus Treated with JAK1 Inhibitor Upadacitinib: A Case Report and Brief Literature Review.Clin Cosmet Investig Dermatol202642713250PubTator, text miningPubMed
Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa.Dermatology202642709635PubTator, text miningPubMed
Case report: Atypical SJS/TEN-like fulminant pemphigus vulgaris: diagnostic challenges and the potential impact of anti-Dsg1 titers and CMV reactivation.Front Immunol202642698938PubTator, text miningPubMed
A Case of Pemphigus Herpetiformis in a 10-Year-Old Child.Clin Cosmet Investig Dermatol202642634662PubTator, text miningPubMed
IgG subclasses and their significance in pemphigus disease progression monitoring.Front Immunol202642591548PubTator, text miningPubMed
When Neurodevelopment Meets Autoimmunity: Pemphigus Foliaceus in Rett Syndrome Expands the Clinical Spectrum-A Case Report.Int J Mol Sci202642589518PubTator, text miningPubMed
Anti-BP180 Mucosal Membrane Pemphigoid With a History of Maxillary Carcinoma With Antibodies to 190 kDa Periplakin and 210 kDa Envoplakin: A Case Report.J Dermatol202642543823PubTator, text miningPubMed

1 to 10 of 3,287

See all 3,287 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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