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Gene · 1829

DSG2: desmoglein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DSG2: desmoglein 2. Genes, record 1829. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1829

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Gene

Symbol
DSG2
HGNC
Name
desmoglein 2
HGNC
NCBI Gene ID
1829
NCBI Gene
HGNC ID
HGNC:3049
HGNC
Ensembl
ENSG00000046604
NCBI Gene
Aliases
CDHF5, HDGC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14126Desmoglein-21,11812Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4824266 A12026-10-2170Q14126Espacenet
EP 4791437 A12026-08-1968Q14126Espacenet
EP 4773979 A12026-07-15190Q14126Espacenet
EP 4705273 A22026-03-11505Q14126Espacenet
US 12564647 B22026-03-03224Q14126Espacenet
JP 2026004568 A2026-01-1443667Q14126Espacenet
EP 4650780 A22025-11-191918Q14126Espacenet
EP 4641201 A22025-10-291507Q14126Espacenet
JP 2025147176 A2025-10-064446Q14126Espacenet
JP 2025529142 A2025-09-041331Q14126Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,602

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDSG2 papersNewest fiscal year
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen342025
R01AR043380Desmoplakin Assembly and Function in Epidermis172025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)172025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92025
R01DK079392Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration92025
T32CA009560Carcinogenesis Training Program82025
P30CA008748Cancer Center Support Grant62025
T32AR007465Penn Dermatology Research Training Program62025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions52025
P30CA016672Cancer Center Support Grant52025

1 to 10 of 1,602Source NIH's project files

See all 1,602 nih grants

Papers2,548

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Desmoglein-2 F833C Is Predicted to Disrupt Hydrophobic Interactions With the Armadillo Repeat Region 1 of Plakoglobin.Cureus202642781589PubTator, text miningPubMed
Generation of an induced pluripotent stem cell line, JHUi010-A, from an arrhythmogenic cardiomyopathy patient harboring pathogenic DSG2 variant c.2358delA.Stem Cell Res202642762668PubTator, text miningPubMed
Heterologous cell-cell junctions support transepithelial endometrial trophoblast invasion in human.Mol Hum Reprod202642714239PubTator, text miningPubMed
FASN-mediated de novo lipogenesis promotes ceramide accumulation and myocardial damage in arrhythmogenic cardiomyopathy.iScience202642701407PubTator, text miningPubMed
DSG2 Expression Marks a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma.Cancers (Basel)202642649925PubTator, text miningPubMed
Inflammatory Hot Phases in Arrhythmogenic Cardiomyopathy: A Dynamic Electrophysiologic Substrate Beyond Scar.JACC Adv202642628220PubTator, text miningPubMed
Breaking bad and taking sides: chamber-specific mitochondrial remodeling in Dsg2-linked arrhythmogenic cardiomyopathy.Am J Physiol Heart Circ Physiol202642581678PubTator, text miningPubMed
N-cadherin orientational order decreases with mechanical load at cardiomyocyte adherens junctions.bioRxiv202642538992PubTator, text miningPubMed
A Rho GTPase-related gene signature predicts prognosis and reveals an immunosuppressive microenvironment in lung adenocarcinoma: an integrated analysis of bulk and single-cell RNA sequencing data.Sci Rep202642469385PubTator, text miningPubMed
Exploring the CD38-Associated Surfaceome via Nanobody-Targeted TurboID.Mol Cell Proteomics202642448231PubTator, text miningPubMed

1 to 10 of 2,548

See all 2,548 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1829

GET https://conductscience.org/api/genes/v1/1829/patents?page=2