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HBEGF: heparin binding EGF like growth factor

1 protein, 145 patents, 1 drug, 1 trial, 4,519 NIH grants and 6,206 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHBEGFHGNC
Nameheparin binding EGF like growth factorHGNC
NCBI Gene ID1839NCBI Gene
HGNC IDHGNC:3059HGNC
EnsemblENSG00000113070NCBI Gene
AliasesDTR, DTS, DTSF, HB-EGF, HEGFLNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q99075Proheparin-binding EGF-like growth factor2082Ensembl, GeneID, HGNCUniProt

Patents 145

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19785Q99075Espacenet
JP 2025529142 A2025-09-041915Q99075Espacenet
EP 4606428 A22025-08-2725Q99075Espacenet
US 12371689 B22025-07-291915Q99075Espacenet
JP 2025517970 A2025-06-12785Q99075Espacenet
JP 2025081589 A2025-05-278Q99075Espacenet
JP 2025081589 A2025-05-27187Q99075Espacenet
EP 4530351 A22025-04-02187Q99075Espacenet
EP 4530351 A22025-04-028Q99075Espacenet
WO 2024252368 A22024-12-12168Q99075Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
KHK-2866CHEMBL2109437Proheparin-binding EGF-like growth factor inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01279291KHK-2866PHASE1ClinicalTrials.gov

NIH grants 4519

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant302,025NIH's project files
P30CA016672Cancer Center Support Grant292,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases242,025NIH's project files
P30CA068485Cancer Center Support Grant212,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support112,025NIH's project files
P30EY008126Core Grant in Vision Research82,025NIH's project files
R01DK062794The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation82,025NIH's project files
R01DK095785Role of the innate immune system in acute kidney injury82,025NIH's project files
P30CA013330Cancer Center Support Grant72,025NIH's project files
P30DK020593Vanderbilt Diabetes Research Center72,025NIH's project files

Papers 6206

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821729PubTator, text miningPubMed
42819089PubTator, text miningPubMed
42776076PubTator, text miningPubMed
42756691PubTator, text miningPubMed
42728404PubTator, text miningPubMed
42709185PubTator, text miningPubMed
42682420PubTator, text miningPubMed
42650831PubTator, text miningPubMed
42649208PubTator, text miningPubMed
42618562PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license