Gene · 1846
DUSP4: dual specificity phosphatase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DUSP4: dual specificity phosphatase 4. Genes, record 1846. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1846
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13115 | Dual specificity protein phosphatase 4 | 394 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44340 | Q13115 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 708 | Q13115 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4405 | Q13115 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 708 | Q13115 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4405 | Q13115 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 25811 | Q13115 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 714 | Q13115 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 128782 | Q13115 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3320 | Q13115 | Espacenet |
| JP 2019158777 A | 2019-09-19 | 860 | Q13115 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,467
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DUSP4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 25 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| U19AI057266 | Vaccine and Infection Induced Immunity in the Young and Aged | 11 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 9 | 2025 |
| R01HL117913 | The NOTCH Signaling Pathway in Large Vessel Vasculitis | 9 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 7 | 2025 |
| P01CA163222 | Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 5 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
1 to 10 of 1,467Source NIH's project files
See all 1,467 nih grantsPapers1,689
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of DUSP4 and NID1 as Biomarkers Related to Cation Homeostasis in Diabetic Retinopathy based on Transcriptomic Analysis | Endocr Metab Immune Disord Drug Targets | 2026 | 42786840 | PubTator, text mining | PubMed |
| Decoding MOF-Enzyme-Substrate Compatibility for Universal Biocatalyst Immobilization. | ACS Appl Mater Interfaces | 2026 | 42742227 | PubTator, text mining | PubMed |
| Spatial atlas of human diabetic kidney uncovered podocyte-driven metabolic-inflammatory crosstalk via glycerolipid reprogramming and DUSP4/MMP3 axis. | Fundam Res | 2026 | 42272503 | PubTator, text mining | PubMed |
| DUSP4-mediated dephosphorylation of PSMD14 enhances PSMD14-dependent deubiquitination of MICALL2 and promotes malignant progression in clear cell renal cell carcinoma. | J Transl Med | 2026 | 42174657 | PubTator, text mining | PubMed |
| Mechanisms coordinating exit from the stem cell state in mammals. | Genes Dev | 2026 | 42156139 | PubTator, text mining | PubMed |
| Emergence of Sprouty role from the signaling interplay of DUSP1 and DUSP4 interactions in NSCLC pathogenesis. | NPJ Syst Biol Appl | 2026 | 42140968 | PubTator, text mining | PubMed |
| DUSP family phosphatases in cell signaling, inflammation, and chronic diseases. | J Biomed Sci | 2026 | 42087139 | PubTator, text mining | PubMed |
| ERKed by too much signaling: from oncogenic driver to therapeutic vulnerability. | Cell Mol Life Sci | 2026 | 41865130 | PubTator, text mining | PubMed |
| RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss. | JCI Insight | 2026 | 41817586 | PubTator, text mining | PubMed |
| Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer. | Signal Transduct Target Ther | 2026 | 41813651 | PubTator, text mining | PubMed |
1 to 10 of 1,689
See all 1,689 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1846
GET https://conductscience.org/api/genes/v1/1846/patents?page=2