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Gene · 1846

DUSP4: dual specificity phosphatase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DUSP4: dual specificity phosphatase 4. Genes, record 1846. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1846

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Gene

Symbol
DUSP4
HGNC
Name
dual specificity phosphatase 4
HGNC
NCBI Gene ID
1846
NCBI Gene
HGNC ID
HGNC:3070
HGNC
Ensembl
ENSG00000120875
NCBI Gene
Aliases
HVH2, MKP-2, MKP2, TYP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13115Dual specificity protein phosphatase 43941Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444340Q13115Espacenet
EP 4641201 A22025-10-29708Q13115Espacenet
EP 4641202 A22025-10-294405Q13115Espacenet
JP 2025517969 A2025-06-12708Q13115Espacenet
KR 1020250017231 A2025-02-044405Q13115Espacenet
US 11446398 B22022-09-2025811Q13115Espacenet
JP 2022092366 A2022-06-22714Q13115Espacenet
JP 2022524081 A2022-04-27128782Q13115Espacenet
US 11078247 B22021-08-033320Q13115Espacenet
JP 2019158777 A2019-09-19860Q13115Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,467

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDUSP4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant252025
P30CA008748Cancer Center Support Grant132025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged112025
P30CA068485Cancer Center Support Grant92025
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis92025
P30CA016086Cancer Center Support Grant82025
P30CA016042Cancer Center Support Grant72025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment52025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)52025

1 to 10 of 1,467Source NIH's project files

See all 1,467 nih grants

Papers1,689

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of DUSP4 and NID1 as Biomarkers Related to Cation Homeostasis in Diabetic Retinopathy based on Transcriptomic AnalysisEndocr Metab Immune Disord Drug Targets202642786840PubTator, text miningPubMed
Decoding MOF-Enzyme-Substrate Compatibility for Universal Biocatalyst Immobilization.ACS Appl Mater Interfaces202642742227PubTator, text miningPubMed
Spatial atlas of human diabetic kidney uncovered podocyte-driven metabolic-inflammatory crosstalk via glycerolipid reprogramming and DUSP4/MMP3 axis.Fundam Res202642272503PubTator, text miningPubMed
DUSP4-mediated dephosphorylation of PSMD14 enhances PSMD14-dependent deubiquitination of MICALL2 and promotes malignant progression in clear cell renal cell carcinoma.J Transl Med202642174657PubTator, text miningPubMed
Mechanisms coordinating exit from the stem cell state in mammals.Genes Dev202642156139PubTator, text miningPubMed
Emergence of Sprouty role from the signaling interplay of DUSP1 and DUSP4 interactions in NSCLC pathogenesis.NPJ Syst Biol Appl202642140968PubTator, text miningPubMed
DUSP family phosphatases in cell signaling, inflammation, and chronic diseases.J Biomed Sci202642087139PubTator, text miningPubMed
ERKed by too much signaling: from oncogenic driver to therapeutic vulnerability.Cell Mol Life Sci202641865130PubTator, text miningPubMed
RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss.JCI Insight202641817586PubTator, text miningPubMed
Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer.Signal Transduct Target Ther202641813651PubTator, text miningPubMed

1 to 10 of 1,689

See all 1,689 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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