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Gene · 1848

DUSP6: dual specificity phosphatase 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DUSP6: dual specificity phosphatase 6. Genes, record 1848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1848

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Gene

Symbol
DUSP6
HGNC
Name
dual specificity phosphatase 6
HGNC
NCBI Gene ID
1848
NCBI Gene
HGNC ID
HGNC:3072
HGNC
Ensembl
ENSG00000139318
NCBI Gene
Aliases
HH19, MKP-3, MKP3, PYST1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16828Dual specificity protein phosphatase 63812Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4831300 A12026-10-2836Q16828Espacenet
EP 4641202 A22025-10-294663Q16828Espacenet
KR 1020250017231 A2025-02-044663Q16828Espacenet
JP 2024123008 A2024-09-105964Q16828Espacenet
US 11446398 B22022-09-2025814Q16828Espacenet
JP 2022524081 A2022-04-27128785Q16828Espacenet
JP 2021175409 A2021-11-0449Q16828Espacenet
US 11078247 B22021-08-033322Q16828Espacenet
US 10501513 B22019-12-105964Q16828Espacenet
JP 2019518426 A2019-07-0415Q16828Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,146

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDUSP6 papersNewest fiscal year
P30CA008748Cancer Center Support Grant212025
P30CA016672Cancer Center Support Grant212025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged192025
R01CA069202Structure/Function of Protein Tyrosine Phosphatases142025
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis142025
P30CA016042Cancer Center Support Grant72025
R01HL142068T Cell Immunity in Giant Cell Arteritis72025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment62025
P30CA045508CSHL Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant62025

1 to 10 of 2,146Source NIH's project files

See all 2,146 nih grants

Papers2,747

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rivaroxaban suppresses factor Xa-Driven PAR-2-ERK inflammatory, catabolic, osteoclastogenic, and mitochondrial dysfunction signaling in osteoarthritis-relevant chondrocytes: a drug-repurposing strategy for joint inflammation.
Front Pharmacol202642741326PubTator, text miningPubMed
Genetic Variation in ADHD-Related Risk Genes in an Indigenous Population of the Amazon.Am J Med Genet B Neuropsychiatr Genet202642581023PubTator, text miningPubMed
Dynamic Control of Cell Signaling with Optogenetic Modulation of Protein Abundance in Living Mammalian Cells.Methods Mol Biol202642573694PubTator, text miningPubMed
Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis.PLoS One202642507727PubTator, text miningPubMed
Redox-dependent mitochondrial dynamics: PLK1 couples glutathione metabolism to ROS-driven JNK and DUSP6 pathways in colorectal cancer.Free Radic Biol Med202642448060PubTator, text miningPubMed
Mechanistic and preclinical evaluation of SIRT3 as a therapeutic target in melanoma.J Derm Oncol202642146866PubTator, text miningPubMed
EPHB2 drives EMT-linked vasculogenic mimicry and cervical cancer progression via an ERK-ETV4 transcriptional program.J Transl Med202642143313PubTator, text miningPubMed
DUSP family phosphatases in cell signaling, inflammation, and chronic diseases.J Biomed Sci202642087139PubTator, text miningPubMed
ADHD polygenic risk predicts neural signatures of cognitive control: Evidence from midfrontal theta dynamics.Transl Psychiatry202641916949PubTator, text miningPubMed
MicroRNA Regulation in Kidney Interstitial Fibrosis.Epigenomes202641892370PubTator, text miningPubMed

1 to 10 of 2,747

See all 2,747 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1848

GET https://conductscience.org/api/genes/v1/1848/patents?page=2