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Gene · 1855

DVL1: dishevelled segment polarity protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DVL1: dishevelled segment polarity protein 1. Genes, record 1855. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1855

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Gene

Symbol
DVL1
HGNC
Name
dishevelled segment polarity protein 1
HGNC
NCBI Gene ID
1855
NCBI Gene
HGNC ID
HGNC:3084
HGNC
Ensembl
ENSG00000107404
NCBI Gene
Aliases
DRS2, DVL, DVL1L1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14640Segment polarity protein dishevelled homolog DVL-16953Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444011O14640Espacenet
EP 4650780 A22025-11-1910102O14640Espacenet
EP 4640849 A22025-10-291529O14640Espacenet
EP 4641201 A22025-10-2910393O14640Espacenet
JP 2025519096 A2025-06-241529O14640Espacenet
JP 2025517969 A2025-06-1210393O14640Espacenet
JP 2025517970 A2025-06-1210102O14640Espacenet
US 11446398 B22022-09-2024930O14640Espacenet
JP 2022524081 A2022-04-27127901O14640Espacenet
US 10918740 B22021-02-16391O14640Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants911

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDVL1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant52025
R35NS105078STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE52025
P30CA068485Cancer Center Support Grant42025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
R01CA231466Molecular mechanisms of protein glycosylation and trafficking42025
UL1TR001863Yale Clinical and Translational Science Award32025
K12HD052896Child Health Research Career Development Award (CHRCDA) Program (K12)22025
P30AI050410The University of North Carolina Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025

1 to 10 of 911Source NIH's project files

See all 911 nih grants

Papers1,433

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
miR-486-3p Suppresses Malignant Phenotypes and is Associated with Reduced WNT5B, DVL1, and β-catenin Expression in Lung Adenocarcinoma Cells.J Vis Exp202642631613PubTator, text miningPubMed
Identification and functional characterization of a novel pathogenic DVL1 gene variant in Robinow syndrome.Mol Genet Genomics202642298173PubTator, text miningPubMed
(S,S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((1-(pyridin-4-yl)ethyl)amino)propan-2-yl)-1H-indole-2-carboxamide, a New Dishevelled 1 and P-Glycoprotein Dual Inhibitor as a Anticancer Agent.
J Med Chem202642283820PubTator, text miningPubMed
First large-scale screening of Notch biallelic variants implicates novel candidate genes in congenital hypothyroidism.J Clin Endocrinol Metab202642192612PubTator, text miningPubMed
Lupane triterpenes isolated from Vasconcellea chilensis (wild papaya) inhibit colorectal cancer cell growth by targeting the Wnt/β-catenin signaling pathway.Fitoterapia202642134482PubTator, text miningPubMed
Clinical features and whole-genome snp association study of chronic active Epstein-Barr virus infection in adults.Virol J202642046143PubTator, text miningPubMed
miR-1247-5p is correlated with cervical cancer and regulates cervical cancer cell functions by targeting DVL1.Nucleosides Nucleotides Nucleic Acids202642033419PubTator, text miningPubMed
Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3-Induced T Cell Activation in Preclinical Models.FASEB J202641863512PubTator, text miningPubMed
IFIT3-DVL interaction promotes malignant progression of lung squamous cell carcinoma and large-cell lung carcinoma via canonical WNT signaling.J Biol Chem202641850400PubTator, text miningPubMed
FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy.FASEB J202641808415PubTator, text miningPubMed

1 to 10 of 1,433

See all 1,433 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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