Gene · 1855
DVL1: dishevelled segment polarity protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DVL1: dishevelled segment polarity protein 1. Genes, record 1855. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1855
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14640 | Segment polarity protein dishevelled homolog DVL-1 | 695 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44011 | O14640 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10102 | O14640 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1529 | O14640 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10393 | O14640 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1529 | O14640 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10393 | O14640 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10102 | O14640 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 24930 | O14640 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 127901 | O14640 | Espacenet |
| US 10918740 B2 | 2021-02-16 | 391 | O14640 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants911
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DVL1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R35NS105078 | STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 4 | 2025 |
| R01CA231466 | Molecular mechanisms of protein glycosylation and trafficking | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| K12HD052896 | Child Health Research Career Development Award (CHRCDA) Program (K12) | 2 | 2025 |
| P30AI050410 | The University of North Carolina Center for AIDS Research | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 2 | 2025 |
1 to 10 of 911Source NIH's project files
See all 911 nih grantsPapers1,433
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| miR-486-3p Suppresses Malignant Phenotypes and is Associated with Reduced WNT5B, DVL1, and β-catenin Expression in Lung Adenocarcinoma Cells. | J Vis Exp | 2026 | 42631613 | PubTator, text mining | PubMed |
| Identification and functional characterization of a novel pathogenic DVL1 gene variant in Robinow syndrome. | Mol Genet Genomics | 2026 | 42298173 | PubTator, text mining | PubMed |
(S,S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((1-(pyridin-4-yl)ethyl)amino)propan-2-yl)-1H-indole-2-carboxamide, a New Dishevelled 1 and P-Glycoprotein Dual Inhibitor as a Anticancer Agent. | J Med Chem | 2026 | 42283820 | PubTator, text mining | PubMed |
| First large-scale screening of Notch biallelic variants implicates novel candidate genes in congenital hypothyroidism. | J Clin Endocrinol Metab | 2026 | 42192612 | PubTator, text mining | PubMed |
| Lupane triterpenes isolated from Vasconcellea chilensis (wild papaya) inhibit colorectal cancer cell growth by targeting the Wnt/β-catenin signaling pathway. | Fitoterapia | 2026 | 42134482 | PubTator, text mining | PubMed |
| Clinical features and whole-genome snp association study of chronic active Epstein-Barr virus infection in adults. | Virol J | 2026 | 42046143 | PubTator, text mining | PubMed |
| miR-1247-5p is correlated with cervical cancer and regulates cervical cancer cell functions by targeting DVL1. | Nucleosides Nucleotides Nucleic Acids | 2026 | 42033419 | PubTator, text mining | PubMed |
| Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3-Induced T Cell Activation in Preclinical Models. | FASEB J | 2026 | 41863512 | PubTator, text mining | PubMed |
| IFIT3-DVL interaction promotes malignant progression of lung squamous cell carcinoma and large-cell lung carcinoma via canonical WNT signaling. | J Biol Chem | 2026 | 41850400 | PubTator, text mining | PubMed |
| FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy. | FASEB J | 2026 | 41808415 | PubTator, text mining | PubMed |
1 to 10 of 1,433
See all 1,433 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1855
GET https://conductscience.org/api/genes/v1/1855/patents