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Gene · 1856

DVL2: dishevelled segment polarity protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DVL2: dishevelled segment polarity protein 2. Genes, record 1856. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1856

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Gene

Symbol
DVL2
HGNC
Name
dishevelled segment polarity protein 2
HGNC
NCBI Gene ID
1856
NCBI Gene
HGNC ID
HGNC:3086
HGNC
Ensembl
ENSG00000004975
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14641Segment polarity protein dishevelled homolog DVL-273615Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918O14641Espacenet
EP 4641201 A22025-10-2915O14641Espacenet
JP 2025517969 A2025-06-1215O14641Espacenet
JP 2025517970 A2025-06-1218O14641Espacenet
US 11446398 B22022-09-2024935O14641Espacenet
JP 2022524081 A2022-04-27127906O14641Espacenet
US 11078247 B22021-08-033328O14641Espacenet
JP 2018518980 A2018-07-1937O14641Espacenet
EP 3317427 A12018-05-0928O14641Espacenet
JP 2017132796 A2017-08-03181O14641Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,016

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDVL2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant92025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P50CA217694SPORE in Soft Tissue Sarcoma52025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
P30DK034854Integrated Epithelial and Muscosal Biology32025
R01LM012806Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data32025
T32AI007526Emerging and Tropical Infectious Diseases32025
T32CA009357Oncology Research Training Grant32025
P01CA206978Comprehensive dissection of the CLL genome & phenome to improve patient outcomes22025

1 to 10 of 1,016Source NIH's project files

See all 1,016 nih grants

Papers1,699

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dishevelled drives disassembly of primary cilia through an unusual PDZ domain-mediated binding mode with Girdin-L.Sci Signal202642771710PubTator, text miningPubMed
E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway.Int J Oncol202642757476PubTator, text miningPubMed
FMRP promotes gastric cancer progression via m6A-dependent stabilization of DVL2 and activation of the Wnt/PCP-JNK pathway.J Transl Med202642698072PubTator, text miningPubMed
Structural basis of internal Vangl2 peptide recognition by the Dvl2 PDZ domain.Mol Biomed202642693382PubTator, text miningPubMed
PRMT7-mediated arginine methylation of FOXK activates Wnt/β-catenin signalling to drive doxorubicin resistance in diffuse large B-cell lymphoma.Clin Transl Med202642683550PubTator, text miningPubMed
A novel dihydroisoxazole derivative DHI9 suppresses colorectal cancer cell survival by inducing oxidative stress, DNA damage, and mitochondrial apoptosis while targeting Akt and Wnt/β-catenin signalling.
Naunyn Schmiedebergs Arch Pharmacol202642678549PubTator, text miningPubMed
Frequently amplified SHANK2 promotes esophageal squamous cell carcinoma progression through the DVL/YAP axis.Oncogene202642675223PubTator, text miningPubMed
Genomic diversification between aposematic and cryptic phenotypes of Oophaga granulifera (Anura: Dendrobatidae).Sci Rep202642661044PubTator, text miningPubMed
Potentially functional variants of Wnt signaling pathway genes predict risk of primary lung cancer in Chinese Han population.Sci Rep202642660981PubTator, text miningPubMed
Expression Profiling and Transcriptional Coordination of Canonical Wnt Signaling Pathway Genes (FZD2, DVL2, and AXIN1) in Chronic Venous Insufficiency.Biomedicines202642652108PubTator, text miningPubMed

1 to 10 of 1,699

See all 1,699 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1856

GET https://conductscience.org/api/genes/v1/1856/patents