Gene · 1856
DVL2: dishevelled segment polarity protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DVL2: dishevelled segment polarity protein 2. Genes, record 1856. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1856
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14641 | Segment polarity protein dishevelled homolog DVL-2 | 736 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 18 | O14641 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15 | O14641 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15 | O14641 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18 | O14641 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 24935 | O14641 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 127906 | O14641 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3328 | O14641 | Espacenet |
| JP 2018518980 A | 2018-07-19 | 37 | O14641 | Espacenet |
| EP 3317427 A1 | 2018-05-09 | 28 | O14641 | Espacenet |
| JP 2017132796 A | 2017-08-03 | 181 | O14641 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,016
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DVL2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
| P50CA217694 | SPORE in Soft Tissue Sarcoma | 5 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 4 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 3 | 2025 |
| R01LM012806 | Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data | 3 | 2025 |
| T32AI007526 | Emerging and Tropical Infectious Diseases | 3 | 2025 |
| T32CA009357 | Oncology Research Training Grant | 3 | 2025 |
| P01CA206978 | Comprehensive dissection of the CLL genome & phenome to improve patient outcomes | 2 | 2025 |
1 to 10 of 1,016Source NIH's project files
See all 1,016 nih grantsPapers1,699
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dishevelled drives disassembly of primary cilia through an unusual PDZ domain-mediated binding mode with Girdin-L. | Sci Signal | 2026 | 42771710 | PubTator, text mining | PubMed |
| E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway. | Int J Oncol | 2026 | 42757476 | PubTator, text mining | PubMed |
| FMRP promotes gastric cancer progression via m6A-dependent stabilization of DVL2 and activation of the Wnt/PCP-JNK pathway. | J Transl Med | 2026 | 42698072 | PubTator, text mining | PubMed |
| Structural basis of internal Vangl2 peptide recognition by the Dvl2 PDZ domain. | Mol Biomed | 2026 | 42693382 | PubTator, text mining | PubMed |
| PRMT7-mediated arginine methylation of FOXK activates Wnt/β-catenin signalling to drive doxorubicin resistance in diffuse large B-cell lymphoma. | Clin Transl Med | 2026 | 42683550 | PubTator, text mining | PubMed |
A novel dihydroisoxazole derivative DHI9 suppresses colorectal cancer cell survival by inducing oxidative stress, DNA damage, and mitochondrial apoptosis while targeting Akt and Wnt/β-catenin signalling. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42678549 | PubTator, text mining | PubMed |
| Frequently amplified SHANK2 promotes esophageal squamous cell carcinoma progression through the DVL/YAP axis. | Oncogene | 2026 | 42675223 | PubTator, text mining | PubMed |
| Genomic diversification between aposematic and cryptic phenotypes of Oophaga granulifera (Anura: Dendrobatidae). | Sci Rep | 2026 | 42661044 | PubTator, text mining | PubMed |
| Potentially functional variants of Wnt signaling pathway genes predict risk of primary lung cancer in Chinese Han population. | Sci Rep | 2026 | 42660981 | PubTator, text mining | PubMed |
| Expression Profiling and Transcriptional Coordination of Canonical Wnt Signaling Pathway Genes (FZD2, DVL2, and AXIN1) in Chronic Venous Insufficiency. | Biomedicines | 2026 | 42652108 | PubTator, text mining | PubMed |
1 to 10 of 1,699
See all 1,699 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1856
GET https://conductscience.org/api/genes/v1/1856/patents