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Gene · 1870

E2F2: E2F transcription factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. E2F2: E2F transcription factor 2. Genes, record 1870. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1870

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Gene

Symbol
E2F2
HGNC
Name
E2F transcription factor 2
HGNC
NCBI Gene ID
1870
NCBI Gene
HGNC ID
HGNC:3114
HGNC
Ensembl
ENSG00000007968
NCBI Gene
Aliases
E2F-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14209Transcription factor E2F24371Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444616Q14209Espacenet
WO 2025235563 A12025-11-1330Q14209Espacenet
EP 4641202 A22025-10-295354Q14209Espacenet
JP 2025147176 A2025-10-0614905Q14209Espacenet
JP 2025028160 A2025-02-2814905Q14209Espacenet
KR 1020250017231 A2025-02-045354Q14209Espacenet
KR 1020250010750 A2025-01-2114905Q14209Espacenet
JP 2024109657 A2024-08-1414744Q14209Espacenet
US 11708396 B22023-07-252202Q14209Espacenet
US 11446398 B22022-09-2026387Q14209Espacenet

1 to 10 of 32

See all 32 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EDIFOLIGIDECHEMBL2108316E2F inhibitorINHIBITORChEMBL
EDIFOLIGIDE SODIUMCHEMBL2109058E2F inhibitorINHIBITORChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,762

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleE2F2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant222025
P30CA008748Cancer Center Support Grant112025
P30CA076292Moffitt Cancer Center Support Grant92025
UL1TR001863Yale Clinical and Translational Science Award92025
P30CA068485Cancer Center Support Grant82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant82025
P30CA016359Cancer Center Support Grant72025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant52025
P30CA056036Translational Research in Cancer52025

1 to 10 of 1,762Source NIH's project files

See all 1,762 nih grants

Papers2,847

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
METTL3-mediated m⁶A methylation of E2F2 targets MCU to promote the malignant phenotype of gastric cancer cells.Cancer Gene Ther202642823456PubTator, text miningPubMed
Subtype-Dependent Transcriptional Coupling Between DNMT1 and E2F-Linked Proliferative Programs in Breast Cancer: A Dual-Cohort Transcriptomic Analysis.J Cancer202642741635PubTator, text miningPubMed
Identification of a nuclear transcriptional module associated with ERα and E2F/FOXM1 signaling across PAM50 breast cancer subtypes.Front Oncol202642620280PubTator, text miningPubMed
Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer.Front Immunol202642614523PubTator, text miningPubMed
Cordycepin inhibits pancreatic cancer progression and enhances gemcitabine sensitivity by targeting the CDK2/E2F2 axis to modulate TNNI2 expression.Biochem Pharmacol202642526773PubTator, text miningPubMed
DYRK1A Signaling in the Brain: Molecular Mechanisms and Neurotransmitter Regulation.Curr Neurovasc Res202642405393PubTator, text miningPubMed
Azacytidine restores T cell function in AML by modulating DNA methylation.bioRxiv202642367853PubTator, text miningPubMed
Hepatitis C virus inhibits the E2F2/PI3K/AKT signaling pathway through miR-378b and leads to glycolipid metabolism disorders in the liver.Mol Biol Rep202642283974PubTator, text miningPubMed
Modeling stimulus-induced stress responses in microglia-like cells using a commercial iPSC-dCas9-KRAB line.Stem Cell Res202642214129PubTator, text miningPubMed
Balancing osteogenesis and adipogenesis in osteogenesis imperfecta: PLIN2 and E2F2 as key targets for mesenchymal stem cell therapy.Adv Clin Exp Med202642186939PubTator, text miningPubMed

1 to 10 of 2,847

See all 2,847 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1870

GET https://conductscience.org/api/genes/v1/1870/patents?page=2