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Gene · 1871

E2F3: E2F transcription factor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. E2F3: E2F transcription factor 3. Genes, record 1871. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1871

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Gene

Symbol
E2F3
HGNC
Name
E2F transcription factor 3
HGNC
NCBI Gene ID
1871
NCBI Gene
HGNC ID
HGNC:3115
HGNC
Ensembl
ENSG00000112242
NCBI Gene
Aliases
E2F-3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00716Transcription factor E2F34650Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444617O00716Espacenet
JP 2025147176 A2025-10-0614906O00716Espacenet
JP 2025032204 A2025-03-1127603O00716Espacenet
JP 2025028160 A2025-02-2814906O00716Espacenet
KR 1020250010750 A2025-01-2114906O00716Espacenet
EP 4461818 A22024-11-1327603O00716Espacenet
JP 2024109657 A2024-08-1414745O00716Espacenet
US 11708396 B22023-07-252201O00716Espacenet
JP 2023058610 A2023-04-2527603O00716Espacenet
US 11446398 B22022-09-2026389O00716Espacenet

1 to 10 of 42

See all 42 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EDIFOLIGIDECHEMBL2108316E2F inhibitorINHIBITORChEMBL
EDIFOLIGIDE SODIUMCHEMBL2109058E2F inhibitorINHIBITORChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,999

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleE2F3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant382025
P30CA008748Cancer Center Support Grant312025
P30CA076292Moffitt Cancer Center Support Grant112025
P30CA016058Cancer Center Support Grant92025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant92025
P30CA016086Cancer Center Support Grant82025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)72025
U54CA1630682/2 Ponce Health Sciences University-Moffitt Cancer Center Partnership72025
U54CA163071(1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership #72025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes62025

1 to 10 of 1,999Source NIH's project files

See all 1,999 nih grants

Papers3,808

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DNA damage response associated miRNA dysregulation in Ataxia-telangiectasia.Mol Biol Rep202642814286PubTator, text miningPubMed
E2F3 amplification primes bladder cancer cells for premature mitosis.Cancer Gene Ther202642773250PubTator, text miningPubMed
Subtype-Dependent Transcriptional Coupling Between DNMT1 and E2F-Linked Proliferative Programs in Breast Cancer: A Dual-Cohort Transcriptomic Analysis.J Cancer202642741635PubTator, text miningPubMed
Serum Peptidomic Analysis in a Comparative Study of the Efficacy of Benjakul Remedy Versus Loratadine in Allergic Rhinitis Patients.Int J Mol Sci202642653391PubTator, text miningPubMed
Complement factor H in cancer biology: intracellular functions, tumor-host interactions, and systemic context.Front Immunol202642592211PubTator, text miningPubMed
Long non-coding RNA LOXL1 antisense RNA 1 promotes the malignancy of non-small cell lung cancer cells via modulating the microRNA-122-5p/E2F transcription factor 3 axis.Mol Genet Genomics202642484731PubTator, text miningPubMed
The diagnostic value and molecular mechanism of miR-199a-5p in recurrent spontaneous abortion.J Assist Reprod Genet202642446609PubTator, text miningPubMed
circ-E2F3 drives ovarian cancer progression via the miR-1305/STAT3 axis through modulation of ferroptosis.Sci Rep202642373708PubTator, text miningPubMed
Paclitaxel and triptolide impair MYC-driven cell cycle via suppressing chromatin reprogramming in ALDH1A3High pancreatic cancer.Phytomedicine202642269181PubTator, text miningPubMed
Correction: ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration.Cell Death Discov202642215439PubTator, text miningPubMed

1 to 10 of 3,808

See all 3,808 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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