Gene · 1874
E2F4: E2F transcription factor 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. E2F4: E2F transcription factor 4. Genes, record 1874. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1874
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16254 | Transcription factor E2F4 | 413 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 10151 | Q16254 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14907 | Q16254 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10151 | Q16254 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 14907 | Q16254 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 14907 | Q16254 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5970 | Q16254 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 14746 | Q16254 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 2205 | Q16254 | Espacenet |
| KR 1020230067931 A | 2023-05-17 | 1 | Q16254 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 26392 | Q16254 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,936
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | E2F4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 20 | 2025 |
| R01ES005775 | Oncometabolites, DNA Repair, and Cancer | 12 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 9 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 8 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 6 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,936Source NIH's project files
See all 1,936 nih grantsPapers2,563
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response. | Nat Commun | 2026 | 42802180 | PubTator, text mining | PubMed |
| N6-methyladenosine-modified circ_0081069: an effective approach to modulate breast cancer's tumor immune microenvironment. | Immunopharmacol Immunotoxicol | 2026 | 42710903 | PubTator, text mining | PubMed |
| Therapeutic targeting of E2F inhibits stemness of salivary gland mucoepidermoid carcinoma. | Cancer Treat Res Commun | 2026 | 42679452 | PubTator, text mining | PubMed |
| PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment. | Front Bioinform | 2026 | 42666350 | PubTator, text mining | PubMed |
| Serum Peptidomic Analysis in a Comparative Study of the Efficacy of Benjakul Remedy Versus Loratadine in Allergic Rhinitis Patients. | Int J Mol Sci | 2026 | 42653391 | PubTator, text mining | PubMed |
| Transcriptomic and genetic evidence highlights EHHADH in a FUNDC1-associated mitochondrial network in diabetic nephropathy. | Metabol Open | 2026 | 42633340 | PubTator, text mining | PubMed |
| Carvacrol induces apoptosis, modulates oxidative stress, and promotes G0/G1 cell cycle arrest in colorectal cancer cells. | Mol Cell Biochem | 2026 | 42440232 | PubTator, text mining | PubMed |
| Bimiralisib suppresses proliferation and migration of gastric cancer cells via PI3K/mTOR pathway inhibition. | Korean J Physiol Pharmacol | 2026 | 42414236 | PubTator, text mining | PubMed |
| E2F4 Mediates Mitophagy to Inhibit Ferroptosis in Esophageal Cancer Cells by Activating GPR176. | Hum Mutat | 2026 | 42253509 | PubTator, text mining | PubMed |
| Targeting USP10/SCD1 axis by RAF265 suppresses lipogenesis and induced ferroptosis in head and neck squamous cell carcinoma. | Cell Death Discov | 2026 | 42230571 | PubTator, text mining | PubMed |
1 to 10 of 2,563
See all 2,563 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1874
GET https://conductscience.org/api/genes/v1/1874/patents?page=2