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Gene · 1874

E2F4: E2F transcription factor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. E2F4: E2F transcription factor 4. Genes, record 1874. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1874

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Gene

Symbol
E2F4
HGNC
Name
E2F transcription factor 4
HGNC
NCBI Gene ID
1874
NCBI Gene
HGNC ID
HGNC:3118
HGNC
Ensembl
ENSG00000205250
NCBI Gene
Aliases
E2F-4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16254Transcription factor E2F44132Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910151Q16254Espacenet
JP 2025147176 A2025-10-0614907Q16254Espacenet
JP 2025517970 A2025-06-1210151Q16254Espacenet
JP 2025028160 A2025-02-2814907Q16254Espacenet
KR 1020250010750 A2025-01-2114907Q16254Espacenet
JP 2024123008 A2024-09-105970Q16254Espacenet
JP 2024109657 A2024-08-1414746Q16254Espacenet
US 11708396 B22023-07-252205Q16254Espacenet
KR 1020230067931 A2023-05-171Q16254Espacenet
US 11446398 B22022-09-2026392Q16254Espacenet

1 to 10 of 37

See all 37 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EDIFOLIGIDECHEMBL2108316E2F inhibitorINHIBITORChEMBL
EDIFOLIGIDE SODIUMCHEMBL2109058E2F inhibitorINHIBITORChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,936

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleE2F4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
R01ES005775Oncometabolites, DNA Repair, and Cancer122025
P30CA008748Cancer Center Support Grant92025
P30CA076292Moffitt Cancer Center Support Grant92025
P30CA016087Cancer Center Support Grant82025
P30CA014599Cancer Center Support Grant62025
P30CA014051Cancer Center Support (Core) Grant52025
P30CA016058Cancer Center Support Grant52025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025

1 to 10 of 1,936Source NIH's project files

See all 1,936 nih grants

Papers2,563

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response.Nat Commun202642802180PubTator, text miningPubMed
N6-methyladenosine-modified circ_0081069: an effective approach to modulate breast cancer's tumor immune microenvironment.Immunopharmacol Immunotoxicol202642710903PubTator, text miningPubMed
Therapeutic targeting of E2F inhibits stemness of salivary gland mucoepidermoid carcinoma.Cancer Treat Res Commun202642679452PubTator, text miningPubMed
PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment.Front Bioinform202642666350PubTator, text miningPubMed
Serum Peptidomic Analysis in a Comparative Study of the Efficacy of Benjakul Remedy Versus Loratadine in Allergic Rhinitis Patients.Int J Mol Sci202642653391PubTator, text miningPubMed
Transcriptomic and genetic evidence highlights EHHADH in a FUNDC1-associated mitochondrial network in diabetic nephropathy.Metabol Open202642633340PubTator, text miningPubMed
Carvacrol induces apoptosis, modulates oxidative stress, and promotes G0/G1 cell cycle arrest in colorectal cancer cells.Mol Cell Biochem202642440232PubTator, text miningPubMed
Bimiralisib suppresses proliferation and migration of gastric cancer cells via PI3K/mTOR pathway inhibition.Korean J Physiol Pharmacol202642414236PubTator, text miningPubMed
E2F4 Mediates Mitophagy to Inhibit Ferroptosis in Esophageal Cancer Cells by Activating GPR176.Hum Mutat202642253509PubTator, text miningPubMed
Targeting USP10/SCD1 axis by RAF265 suppresses lipogenesis and induced ferroptosis in head and neck squamous cell carcinoma.Cell Death Discov202642230571PubTator, text miningPubMed

1 to 10 of 2,563

See all 2,563 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1874

GET https://conductscience.org/api/genes/v1/1874/patents?page=2