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Gene · 1889

ECE1: endothelin converting enzyme 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ECE1: endothelin converting enzyme 1. Genes, record 1889. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1889

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Gene

Symbol
ECE1
HGNC
Name
endothelin converting enzyme 1
HGNC
NCBI Gene ID
1889
NCBI Gene
HGNC ID
HGNC:3146
HGNC
Ensembl
ENSG00000117298
NCBI Gene
Aliases
ECE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42892Endothelin-converting enzyme 17701Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444977P42892Espacenet
EP 4650780 A22025-11-199546P42892Espacenet
EP 4641201 A22025-10-299800P42892Espacenet
JP 2025529142 A2025-09-041348P42892Espacenet
US 12371689 B22025-07-291348P42892Espacenet
JP 2025517969 A2025-06-129800P42892Espacenet
JP 2025517970 A2025-06-129546P42892Espacenet
JP 2025032204 A2025-03-1127630P42892Espacenet
EP 4461818 A22024-11-1327630P42892Espacenet
JP 2023058610 A2023-04-2527630P42892Espacenet

1 to 10 of 55

See all 55 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
DAGLUTRILCHEMBL3989794Endothelin-converting enzyme 1 inhibitorINHIBITOR

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00160225DAGLUTRILPHASE2ClinicalTrials.gov
NCT00160212DAGLUTRILPHASE2ClinicalTrials.gov

NIH grants1,032

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleECE1 papersNewest fiscal year
R37DE022550Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis112025
R01AI134796Candidalysin: a key mediator of Candida vaginitis immunopathology42025
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension32025
ZIAAG000311ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)32025
K24AG070459Genetic determinants of thoracic aortic stiffness and remodeling22025
P30CA006973Regional Oncology Research Center22025
P30CA016042Cancer Center Support Grant22025
P30DK063491Diabetes Research Center (DRC)22025
P30DK120515San Diego Digestive Diseases Research Center22025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)22025

1 to 10 of 1,032Source NIH's project files

See all 1,032 nih grants

Papers1,622

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omics Mendelian randomisation reveals distinct molecular drivers of pathological myopia complications vs simple myopia.J Glob Health202642825359PubTator, text miningPubMed
Analysis of the expression of genes encoding the endothelin signaling pathway in fetal, heathy, and diseased adult human heart using single-cell transcriptomics.Can J Physiol Pharmacol202642753274PubTator, text miningPubMed
Candidalysin at the epithelial-systemic interface: mechanistic evidence, critical-care relevance, and translational opportunities in invasive candidiasis.Front Cell Infect Microbiol202642657083PubTator, text miningPubMed
Exposure-informed lung transcriptomic analysis links predicted NNK targets to cell type-specific remodeling programs in idiopathic pulmonary fibrosis.Funct Integr Genomics202642533188PubTator, text miningPubMed
Antifungal and anti-biofilm activity of doxepin against Candida spp. mediated by oxidative stress and modulation of adhesion-related genes.Microb Pathog202642508701PubTator, text miningPubMed
The unique Efg1 fungal virulence regulon in the catheterized bladder environment.Proc Natl Acad Sci U S A202642475584PubTator, text miningPubMed
Placental discrepancies between Black and White patients with preeclampsia in a southeastern US cohort.Am J Physiol Endocrinol Metab202642227699PubTator, text miningPubMed
ECE1c promotes glioblastoma invasion via the ROCK2-MYH10 axis and interaction with ACTB.Am J Transl Res202642007117PubTator, text miningPubMed
Anti-biofilm and associated anti-virulence activities of sucrose fatty acid esters against human pathogens.Microb Pathog202641942038PubTator, text miningPubMed
Molecular Markers Distinguishing Early-Stage Mycosis Fungoides From Atopic Dermatitis Skin Lesions.Exp Dermatol202641888970PubTator, text miningPubMed

1 to 10 of 1,622

See all 1,622 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1889

GET https://conductscience.org/api/genes/v1/1889/patents?page=2