ConductScience.org, home

Gene · 1894

ECT2: epithelial cell transforming 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ECT2: epithelial cell transforming 2. Genes, record 1894. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1894

On this page

Gene

Symbol
ECT2
HGNC
Name
epithelial cell transforming 2
HGNC
NCBI Gene ID
1894
NCBI Gene
HGNC ID
HGNC:3155
HGNC
Ensembl
ENSG00000114346
NCBI Gene
Aliases
ARHGEF31
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H8V3Protein ECT29143Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910949Q9H8V3Espacenet
EP 4641201 A22025-10-2911348Q9H8V3Espacenet
EP 4641202 A22025-10-295856Q9H8V3Espacenet
JP 2025517969 A2025-06-1211348Q9H8V3Espacenet
JP 2025517970 A2025-06-1210949Q9H8V3Espacenet
KR 1020250017231 A2025-02-045856Q9H8V3Espacenet
JP 2024123008 A2024-09-106022Q9H8V3Espacenet
JP 2024123008 A2024-09-106028Q9H8V3Espacenet
US 11446398 B22022-09-2027748Q9H8V3Espacenet
JP 2022524081 A2022-04-27130719Q9H8V3Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants856

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleECT2 papersNewest fiscal year
T32CA071341Cancer Cell Biology Training Program62025
P30CA016672Cancer Center Support Grant52025
P30CA076292Moffitt Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30ES013508Center of Excellence in Environmental Toxicology42025
R01DK064380Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA014520UW Comprehensive Cancer Center Support32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025
P30CA093373Cancer Center Support Grant P3032025

1 to 10 of 856Source NIH's project files

See all 856 nih grants

Papers1,404

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative single-cell and machine learning analysis identifies a tumor doubling time-related prognostic signature and therapeutic targets in head and neck squamous cell carcinoma.Transl Oncol202642492364PubTator, text miningPubMed
PRKCI-ECT2 copy number gain promotes developmental reprogramming and metastatic competence in lung adenocarcinoma.Cell Rep202642470637PubTator, text miningPubMed
A preliminary study of ECT2 as a novel biomarker for assessing liver fibrosis and prognosis in biliary atresia.Front Pediatr202642445574PubTator, text miningPubMed
A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts therapeutic response.Oncol Lett202642383289PubTator, text miningPubMed
Effects from combined exposure to arsenic and dichloromethane: in vitro expression of genotoxicity, transformation and metastatic potential for cholangiocarcinogenesis.Chem Biol Interact202642379413PubTator, text miningPubMed
Early induction of the Rho-GEF ECT2 drives MEK/ERK oncogenic signaling in pancreatic ductal adenocarcinoma.Oncogene202642321532PubTator, text miningPubMed
Identification and validation of prognostic genes related to centrosome amplification in multiple myeloma.PeerJ202642261309PubTator, text miningPubMed
A TRPM4-associated necrotic cell death signature for prognostic stratification in pancreatic cancer.J Gastrointest Oncol202642169933PubTator, text miningPubMed
Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women.Front Oncol202641952686PubTator, text miningPubMed
TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells.Life Sci Alliance202641844278PubTator, text miningPubMed

1 to 10 of 1,404

See all 1,404 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1894

GET https://conductscience.org/api/genes/v1/1894/patents?page=2