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ABCA1: ATP binding cassette subfamily A member 1

1 protein, 83 patents, 1 drug, 7 trials, 5,781 NIH grants and 11,220 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolABCA1HGNC
NameATP binding cassette subfamily A member 1HGNC
NCBI Gene ID19NCBI Gene
HGNC IDHGNC:29HGNC
EnsemblENSG00000165029NCBI Gene
AliasesABC-1, ABC1, CERP, HDLCQTL13, HDLDT1, HPALP1, TGDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O95477Phospholipid-transporting ATPase ABCA12,2617Ensembl, GeneID, HGNCUniProt

Patents 83

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082924 A2026-05-1911O95477Espacenet
JP 2026004568 A2026-01-1438347O95477Espacenet
EP 4650780 A22025-11-199514O95477Espacenet
EP 4640849 A22025-10-291430O95477Espacenet
EP 4641201 A22025-10-299760O95477Espacenet
EP 4641202 A22025-10-29540O95477Espacenet
JP 2025529142 A2025-09-04175O95477Espacenet
US 12371689 B22025-07-29175O95477Espacenet
JP 2025519096 A2025-06-241430O95477Espacenet
JP 2025517969 A2025-06-129760O95477Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PROBUCOLCHEMBL608ATP-binding cassette sub-family A member 1 inhibitorINHIBITORChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06931834PROBUCOLClinicalTrials.gov
NCT06604117PROBUCOLClinicalTrials.gov
NCT02707458PROBUCOLPHASE1/PHASE2ClinicalTrials.gov
NCT01726816PROBUCOLPHASE2ClinicalTrials.gov
NCT01349010PROBUCOLPHASE3ClinicalTrials.gov
NCT01142284PROBUCOLPHASE2ClinicalTrials.gov
NCT00655330PROBUCOLClinicalTrials.gov

NIH grants 5781

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK017047Diabetes Research Center612,025NIH's project files
P30DK063491Diabetes Research Center (DRC)342,025NIH's project files
P01HL116263HDL Function in Human Disease312,025NIH's project files
R01HL107653Cholesterol efflux, CHIP and inflammasome activation212,025NIH's project files
ZIAHL006095Development of Apo Mimetic Peptides for the Treatment Cardiovascular Disease202,025NIH's project files
P01HL128203Multi-disciplinary Approaches to HDL Structure, Assembly, and Functional Heterogeneity192,025NIH's project files
P30AI117970District of Columbia Center for AIDS Research172,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)172,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)172,025NIH's project files
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease142,025NIH's project files

Papers 11220

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807170PubTator, text miningPubMed
42794805PubTator, text miningPubMed
42794670PubTator, text miningPubMed
42792654PubTator, text miningPubMed
42767505PubTator, text miningPubMed
42762373PubTator, text miningPubMed
42757464PubTator, text miningPubMed
42754173PubTator, text miningPubMed
42745992PubTator, text miningPubMed
42741945PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license