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S1PR1: sphingosine-1-phosphate receptor 1

1 protein, 82 patents, 16 drugs, 172 trials, 3,249 NIH grants and 5,341 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolS1PR1HGNC
Namesphingosine-1-phosphate receptor 1HGNC
NCBI Gene ID1901NCBI Gene
HGNC IDHGNC:3165HGNC
EnsemblENSG00000170989NCBI Gene
AliasesCD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, edg-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21453Sphingosine 1-phosphate receptor 138221Ensembl, GeneID, HGNCUniProt

Patents 82

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1053P21453Espacenet
WO 2026017877 A12026-01-2244P21453Espacenet
EP 4650780 A22025-11-194341P21453Espacenet
JP 2025529142 A2025-09-043810P21453Espacenet
US 12371689 B22025-07-293810P21453Espacenet
JP 2025517970 A2025-06-124341P21453Espacenet
JP 2025032204 A2025-03-1135203P21453Espacenet
EP 4461818 A22024-11-1335203P21453Espacenet
JP 2024123008 A2024-09-108531P21453Espacenet
JP 2024112982 A2024-08-214336P21453Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISELIMODCHEMBL3707375Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
AMISELIMOD HYDROCHLORIDECHEMBL3707374Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
CENERIMODCHEMBL4297505Sphingosine 1-phosphate receptor Edg-1 modulatorMODULATORChEMBL
ETRASIMODCHEMBL3358920Sphingosine 1-phosphate receptor Edg-1 agonistAGONISTChEMBL
ETRASIMODCHEMBL3358920Sphingosine 1-phosphate receptor Edg-1 modulatorMODULATORChEMBL
ETRASIMOD ARGININECHEMBL3989933Sphingosine 1-phosphate receptor Edg-1 modulatorMODULATORChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL
FINGOLIMOD HYDROCHLORIDECHEMBL544665Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMOD LAURYL SULFATECHEMBL5095050Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL

Trials 172

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07483632FINGOLIMODPHASE3ClinicalTrials.gov
NCT07470879ETRASIMODPHASE2ClinicalTrials.gov
NCT07459686ETRASIMOD ARGININEClinicalTrials.gov
NCT07271069OZANIMODClinicalTrials.gov
NCT07266090CENERIMODPHASE2ClinicalTrials.gov
NCT07243639ETRASIMODClinicalTrials.gov
NCT07220252FINGOLIMODPHASE2/PHASE3ClinicalTrials.gov
NCT07201129CENERIMODPHASE3ClinicalTrials.gov
NCT06862960OZANIMODPHASE2ClinicalTrials.gov
NCT06639282SIPONIMODPHASE2ClinicalTrials.gov

NIH grants 3249

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01CA097132Sphingolipids in Cancer Biology and Therapy212,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant202,025NIH's project files
R01NS103988PET Sphingosine-1-Phosphate Receptor 1 (S1P1) radiotracer for inflammation response in multiple sclerosis162,025NIH's project files
ZIADK056014Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms132,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant122,025NIH's project files
P30CA008748Cancer Center Support Grant102,025NIH's project files
P30CA016672Cancer Center Support Grant102,025NIH's project files
P41EB025815The PET Radiotracer Translation and Resource Center (PET-RTRC)102,025NIH's project files
P30CA138313Medical University of South Carolina - Cancer Center Support Grant92,025NIH's project files
P51OD011132Emory National Primate Research Center92,025NIH's project files

Papers 5341

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42787432PubTator, text miningPubMed
42780639PubTator, text miningPubMed
42728317PubTator, text miningPubMed
42722901PubTator, text miningPubMed
42686559PubTator, text miningPubMed
42678598PubTator, text miningPubMed
42655205PubTator, text miningPubMed
42614945PubTator, text miningPubMed
42557328PubTator, text miningPubMed
42542688PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license