Gene · 1902
LPAR1: lysophosphatidic acid receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LPAR1: lysophosphatidic acid receptor 1. Genes, record 1902. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1902
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92633 | Lysophosphatidic acid receptor 1 | 364 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents158
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12599645 B2 | 2026-04-14 | 62 | Q92633 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52126 | Q92633 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52127 | Q92633 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52128 | Q92633 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7606 | Q92633 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7626 | Q92633 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2404 | Q92633 | Espacenet |
| EP 4606896 A1 | 2025-08-27 | 111 | Q92633 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2404 | Q92633 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7626 | Q92633 | Espacenet |
1 to 10 of 158
See all 158 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BMS-986020 | CHEMBL4297270 | Lysophosphatidic acid receptor Edg-2 antagonist | ANTAGONIST |
Source ChEMBL
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02588625 | BMS-986020 | PHASE2 | ClinicalTrials.gov | |
| NCT01766817 | BMS-986020 | PHASE2 | 2019-05-22 | ClinicalTrials.gov |
NIH grants1,431
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LPAR1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 9 | 2025 |
| T32CA154274 | Training Grant in Cancer Biology | 5 | 2025 |
| P30ES001247 | Environmental Agents as Modulators of Disease Processes | 4 | 2025 |
| P01DA009158 | Endocannabinoid Active Sites as Therapeutic Targets | 3 | 2025 |
| P20GM121307 | Center for Redox Biology and Cardiovascular Disease | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 3 | 2025 |
| P30CA134274 | UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT | 3 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,431Source NIH's project files
See all 1,431 nih grantsPapers2,112
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Lactic acid exposure alters lysophosphatidic acid receptor-mediated regulation of growth and motility in pancreatic cancer cells. | Mol Cell Biochem | 2026 | 42663874 | PubTator, text mining | PubMed |
| Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps. | Inflamm Res | 2026 | 42550283 | PubTator, text mining | PubMed |
| LPA/LPAR signaling drives temporomandibular disorders-like pain through regulating the expression and sensitization of PIEZO2. | Sci Adv | 2026 | 42490435 | PubTator, text mining | PubMed |
| Lysophosphatidic acid promotes lipid metabolism through AMPK signaling to support Coxsackievirus infection. | J Virol | 2026 | 42461030 | PubTator, text mining | PubMed |
| Biomarker profiles in idiopathic and progressive pulmonary fibrosis after LPA1 antagonism: exploratory analysis from a phase 2 trial of admilparant. | Respir Res | 2026 | 42458495 | PubTator, text mining | PubMed |
| Lysophosphatidic acid (LPA) receptor-mediated signaling in the tumor microenvironment: roles in cancer progression and therapeutic potential. | Adv Biol Regul | 2026 | 42456206 | PubTator, text mining | PubMed |
| M2 Macrophage-Derived ENPP2/LPA Signalling Attenuates UVB-Induced Fibroblast Photoaging via LPAR1/3. | Exp Dermatol | 2026 | 42394134 | PubTator, text mining | PubMed |
| Discovery of PIPE-791, A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders. | J Med Chem | 2026 | 42370792 | PubTator, text mining | PubMed |
| Targeting phospholipase A2 with arachidonyl trifluoromethyl ketone modulates macrophage activation during Japanese encephalitis virus infection. | Med Microbiol Immunol | 2026 | 42189285 | PubTator, text mining | PubMed |
| A patent review of LPAR1 antagonists (2010 - present). | Expert Opin Ther Pat | 2026 | 42132000 | PubTator, text mining | PubMed |
1 to 10 of 2,112
See all 2,112 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1902
GET https://conductscience.org/api/genes/v1/1902/patents?page=2