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Gene · 1907

EDN2: endothelin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EDN2: endothelin 2. Genes, record 1907. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1907

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Gene

Symbol
EDN2
HGNC
Name
endothelin 2
HGNC
NCBI Gene ID
1907
NCBI Gene
HGNC ID
HGNC:3177
HGNC
Ensembl
ENSG00000127129
NCBI Gene
Aliases
ET-2, ET2, PPET2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20800Endothelin-21780Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444969P20800Espacenet
EP 4650780 A22025-11-199129P20800Espacenet
JP 2025147176 A2025-10-064542P20800Espacenet
JP 2025529142 A2025-09-046229P20800Espacenet
US 12371689 B22025-07-296229P20800Espacenet
JP 2025517970 A2025-06-129129P20800Espacenet
JP 2025028160 A2025-02-284542P20800Espacenet
KR 1020250010750 A2025-01-214542P20800Espacenet
JP 2024109657 A2024-08-144549P20800Espacenet
US 11446398 B22022-09-2027357P20800Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants680

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEDN2 papersNewest fiscal year
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
I01BX000347Cerebral Arteriole Structure/Function in Diabetic Ischemic Brain Injury32025
IK6BX004471BLR&D Research Career Scientist Award Application32025
T32HL007208Integrated, Multidisciplinary Training in Cardiovascular Research32025
P20GM103476Mississippi INBRE22025
P30CA006973Regional Oncology Research Center22025
P30CA008748Cancer Center Support Grant22025
P30CA016087Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025

1 to 10 of 680Source NIH's project files

See all 680 nih grants

Papers1,494

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Analysis of the expression of genes encoding the endothelin signaling pathway in fetal, heathy, and diseased adult human heart using single-cell transcriptomics.Can J Physiol Pharmacol202642753274PubTator, text miningPubMed
Lipid Architecture in the Zika Virus.ACS Phys Chem Au202642500223PubTator, text miningPubMed
EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas.Mol Oncol202642026941PubTator, text miningPubMed
Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis.World J Exp Med202641883439PubTator, text miningPubMed
Identification of hypoxia-related gene signatures and molecular subtypes in chronic rhinosinusitis with nasal polyps.Braz J Otorhinolaryngol202641855680PubTator, text miningPubMed
Reactive Stroma as a Transversal Prognostic Biomarker for Metastasis in Breast Cancer: Integration of Digital Histopathology and Transcriptomic Profiling.Int J Mol Sci202641828443PubTator, text miningPubMed
Er3+/Yb3+ co-doped ZnS quantum dots: structure, optical properties and up-conversion luminescence.RSC Adv202641799918PubTator, text miningPubMed
From essential thrombocythemia to polycythemia vera (ET-2-PV): rationale and design of a multicenter ELN study.Ann Hematol202641776088PubTator, text miningPubMed
Serum endothelin-1 and endothelin-2 levels in healthy controls and circadian hypertension phenotypes: A comparison of dipper and non-dipper patients.Clin Exp Hypertens202641774498PubTator, text miningPubMed
Further Computations of Quantum Fluid Triplet Structures at Equilibrium in the Diffraction Regime.Entropy (Basel)202641751733PubTator, text miningPubMed

1 to 10 of 1,494

See all 1,494 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1907

GET https://conductscience.org/api/genes/v1/1907/patents?page=2