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Gene · 1908

EDN3: endothelin 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EDN3: endothelin 3. Genes, record 1908. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1908

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Gene

Symbol
EDN3
HGNC
Name
endothelin 3
HGNC
NCBI Gene ID
1908
NCBI Gene
HGNC ID
HGNC:3178
HGNC
Ensembl
ENSG00000124205
NCBI Gene
Aliases
ET-3, ET3, HSCR4, PPET3, WS4B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14138Endothelin-32381Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444971P14138Espacenet
JP 2026004568 A2026-01-1444973P14138Espacenet
JP 2025172884 A2025-11-261P14138Espacenet
EP 4650780 A22025-11-196249P14138Espacenet
EP 4641201 A22025-10-296012P14138Espacenet
JP 2025147176 A2025-10-064545P14138Espacenet
JP 2025147176 A2025-10-064546P14138Espacenet
JP 2025529142 A2025-09-046230P14138Espacenet
US 12371689 B22025-07-296230P14138Espacenet
JP 2025517969 A2025-06-126012P14138Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,222

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEDN3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA010815Consolidated Basic Cancer Research Program82025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal52025
T32HL007208Integrated, Multidisciplinary Training in Cardiovascular Research42025
ZIAHL006001Framingham Project/Levy42025
I01BX000347Cerebral Arteriole Structure/Function in Diabetic Ischemic Brain Injury32025
IK6BX004471BLR&D Research Career Scientist Award Application32025
P30CA068485Cancer Center Support Grant32025
P30CA072720Cancer Center Support Grant32025
P30DK036836Diabetes Research Center32025

1 to 10 of 1,222Source NIH's project files

See all 1,222 nih grants

Papers2,260

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Analysis of urinary kidney-specific cell-free DNA in preeclampsia.PLoS One202642809538PubTator, text miningPubMed
Analysis of the expression of genes encoding the endothelin signaling pathway in fetal, heathy, and diseased adult human heart using single-cell transcriptomics.Can J Physiol Pharmacol202642753274PubTator, text miningPubMed
808 nm-excited highly-pure red upconversion emission from Er3+ in bi-perovskite Ca2ScSbO6 via Yb3+-mediated energy transfer.Spectrochim Acta A Mol Biomol Spectrosc202642480485PubTator, text miningPubMed
Rexiao Kuining decoction ameliorates ulcerative colitis by restoring immune homeostasis via the protein kinase C alpha-FMS-like tyrosine kinase 3 ligand axis: multi-omics evidence.J Ethnopharmacol202642264446PubTator, text miningPubMed
Cumulative Reproductive Outcomes Across Three Embryo Transfer Cycles After Hysteroscopic Endometrial Polypectomy Using a Tissue Removal System in Infertile Women: A Single-Center Retrospective Cohort Study.
Diagnostics (Basel)202642122089PubTator, text miningPubMed
Network pharmacology reveals lidocaine's modulation of proliferation and apoptosis in breast cancer cells: regulation of cellular lipid metabolism.Arch Physiol Biochem202642102290PubTator, text miningPubMed
EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas.Mol Oncol202642026941PubTator, text miningPubMed
Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis.World J Exp Med202641883439PubTator, text miningPubMed
Machine learning derived ORC6 as a hub biomarker for predicting tumor microenvironment, prognoses, and therapeutic responses in lung adenocarcinoma.Transl Oncol202641875810PubTator, text miningPubMed
A cis-regulatory mutation in the EDN3 promoter drives coordinated formation of comb and skin color in Anyi gray chickens.Poult Sci202641850061PubTator, text miningPubMed

1 to 10 of 2,260

See all 2,260 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1908

GET https://conductscience.org/api/genes/v1/1908/patents?page=2