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EDNRB: endothelin receptor type B

1 protein, 211 patents, 10 drugs, 189 trials, 2,572 NIH grants and 5,432 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEDNRBHGNC
Nameendothelin receptor type BHGNC
NCBI Gene ID1910NCBI Gene
HGNC IDHGNC:3180HGNC
EnsemblENSG00000136160NCBI Gene
AliasesABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4ANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P24530Endothelin receptor type B44218Ensembl, GeneID, HGNCUniProt

Patents 211

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1037P24530Espacenet
EP 4650780 A22025-11-1919009P24530Espacenet
EP 4641201 A22025-10-2923777P24530Espacenet
JP 2025147176 A2025-10-064551P24530Espacenet
JP 2025147176 A2025-10-064553P24530Espacenet
JP 2025147176 A2025-10-064555P24530Espacenet
JP 2025147176 A2025-10-064556P24530Espacenet
JP 2025147176 A2025-10-064557P24530Espacenet
JP 2025529142 A2025-09-041355P24530Espacenet
JP 2025529142 A2025-09-046231P24530Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMBRISENTANCHEMBL1111Endothelin receptor, ET-A/ET-B antagonistANTAGONISTChEMBL
APROCITENTANCHEMBL2165326Endothelin receptor, ET-A/ET-B antagonistANTAGONISTChEMBL
BOSENTANCHEMBL957Endothelin receptor, ET-A/ET-B antagonistANTAGONISTChEMBL
DARUSENTANCHEMBL23261Endothelin receptor ET-B antagonistANTAGONISTChEMBL
ENRASENTANCHEMBL431651Endothelin receptor ET-B antagonistANTAGONISTChEMBL
MACITENTANCHEMBL2103873Endothelin receptor, ET-A/ET-B antagonistANTAGONISTChEMBL
RG-7636CHEMBL2109282Endothelin receptor ET-B binding agentBINDING AGENTChEMBL
SITAXENTANCHEMBL282724Endothelin receptor, ET-A/ET-B antagonistANTAGONISTChEMBL
SITAXENTAN SODIUMCHEMBL2105740Endothelin receptor, ET-A/ET-B antagonistANTAGONISTChEMBL
TEZOSENTANCHEMBL61780Endothelin receptor ET-B antagonistANTAGONISTChEMBL

Trials 189

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07245680AMBRISENTANPHASE3ClinicalTrials.gov
NCT06987097AMBRISENTANClinicalTrials.gov
NCT06968962AMBRISENTANClinicalTrials.gov
NCT06957002BOSENTANPHASE2ClinicalTrials.gov
NCT06887062BOSENTANPHASE2ClinicalTrials.gov
NCT06256432AMBRISENTANPHASE2ClinicalTrials.gov
NCT05731492MACITENTANPHASE1ClinicalTrials.gov
NCT05437224AMBRISENTANPHASE3ClinicalTrials.gov
NCT05179876MACITENTANPHASE3ClinicalTrials.gov
NCT05167825MACITENTANPHASE32025-10-21ClinicalTrials.gov

NIH grants 2572

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant142,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
I01BX000347Cerebral Arteriole Structure/Function in Diabetic Ischemic Brain Injury92,025NIH's project files
R01HD072929Optimal Oxygenation in Neonatal Lung Injury92,025NIH's project files
IK6BX004471BLR&D Research Career Scientist Award Application72,025NIH's project files
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 272,025NIH's project files
P30CA006973Regional Oncology Research Center72,025NIH's project files
P20GM113125Center of Biomedical Research Excellence in Cardiovascular Health52,025NIH's project files
P30CA068485Cancer Center Support Grant52,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52,025NIH's project files

Papers 5432

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42792677PubTator, text miningPubMed
42775555PubTator, text miningPubMed
42753274PubTator, text miningPubMed
42711567PubTator, text miningPubMed
42619591PubTator, text miningPubMed
42601615PubTator, text miningPubMed
42595249PubTator, text miningPubMed
42555850PubTator, text miningPubMed
42527029PubTator, text miningPubMed
42488394PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license