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EEF2: eukaryotic translation elongation factor 2

1 protein, 65 patents, 11 drugs, 108 trials, 3,060 NIH grants and 4,836 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEEF2HGNC
Nameeukaryotic translation elongation factor 2HGNC
NCBI Gene ID1938NCBI Gene
HGNC IDHGNC:3214HGNC
EnsemblENSG00000167658NCBI Gene
AliasesEEF-2, EF-2, EF2, SCA26NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P13639Elongation factor 285825Ensembl, GeneID, HGNCUniProt

Patents 65

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445454P13639Espacenet
EP 4650780 A22025-11-194530P13639Espacenet
EP 4641201 A22025-10-294087P13639Espacenet
EP 4641202 A22025-10-294826P13639Espacenet
JP 2025517969 A2025-06-124087P13639Espacenet
JP 2025517970 A2025-06-124530P13639Espacenet
KR 1020250017231 A2025-02-044826P13639Espacenet
JP 2023123507 A2023-09-05180P13639Espacenet
US 11446398 B22022-09-2028592P13639Espacenet
JP 2022537339 A2022-08-25108P13639Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CINTREDEKIN BESUDOTOXCHEMBL2108583Elongation factor 2 inhibitorINHIBITORChEMBL
DENILEUKIN DIFTITOXCHEMBL1201550Elongation factor 2 inhibitorINHIBITORChEMBL
LMB-1CHEMBL2109306Elongation factor 2 inhibitorINHIBITORChEMBL
LMB-100CHEMBL4297777Elongation factor 2 disrupting agentDISRUPTING AGENTChEMBL
LMB-2CHEMBL2109367Elongation factor 2 inhibitorINHIBITORChEMBL
LMB-7CHEMBL2109307Elongation factor 2 inhibitorINHIBITORChEMBL
LMB-9CHEMBL2109503Elongation factor 2 inhibitorINHIBITORChEMBL
MOXETUMOMAB PASUDOTOXCHEMBL1743043Elongation factor 2 inhibitorINHIBITORChEMBL
OPORTUZUMAB MONATOXCHEMBL1743052Elongation factor 2 inhibitorINHIBITORChEMBL
RESIMMUNECHEMBL4297555Elongation factor 2 inhibitorINHIBITORChEMBL

Trials 108

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07148180TAGRAXOFUSPPHASE1/PHASE2ClinicalTrials.gov
NCT07007052TAGRAXOFUSPPHASE2ClinicalTrials.gov
NCT06561152TAGRAXOFUSPPHASE1/PHASE2ClinicalTrials.gov
NCT06498973TAGRAXOFUSPPHASE1ClinicalTrials.gov
NCT06456463TAGRAXOFUSPPHASE2ClinicalTrials.gov
NCT06414681TAGRAXOFUSPEARLY_PHASE1ClinicalTrials.gov
NCT05720988TAGRAXOFUSPPHASE1ClinicalTrials.gov
NCT05716009TAGRAXOFUSPPHASE1ClinicalTrials.gov
NCT05476770TAGRAXOFUSPPHASE1ClinicalTrials.gov
NCT05442216TAGRAXOFUSPPHASE2ClinicalTrials.gov

NIH grants 3060

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant282,025NIH's project files
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center162,025NIH's project files
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect142,025NIH's project files
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders142,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
ZIABC010301Development of Recombinant Toxins to Treat Hematologic Malignancies112,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant102,025NIH's project files
ZIABC008757Bio-Therapies for the Treatment of Cancer102,025NIH's project files
R35GM122602Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality control92,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files

Papers 4836

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42778572PubTator, text miningPubMed
42689549PubTator, text miningPubMed
42598390PubTator, text miningPubMed
42580971PubTator, text miningPubMed
42517924PubTator, text miningPubMed
42378855PubTator, text miningPubMed
42377747PubTator, text miningPubMed
42284146PubTator, text miningPubMed
42277459PubTator, text miningPubMed
42241768PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license