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Gene · 1942

EFNA1: ephrin A1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EFNA1: ephrin A1. Genes, record 1942. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1942

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Gene

Symbol
EFNA1
HGNC
Name
ephrin A1
HGNC
NCBI Gene ID
1942
NCBI Gene
HGNC ID
HGNC:3221
HGNC
Ensembl
ENSG00000169242
NCBI Gene
Aliases
B61, ECKLG, EPLG1, GMAN, LERK-1, LERK1, TNFAIP4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20827Ephrin-A12053Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198452P20827Espacenet
EP 4640849 A22025-10-291272P20827Espacenet
EP 4641201 A22025-10-298618P20827Espacenet
JP 2025147176 A2025-10-064582P20827Espacenet
JP 2025529142 A2025-09-046234P20827Espacenet
US 12371689 B22025-07-296234P20827Espacenet
JP 2025519096 A2025-06-241272P20827Espacenet
JP 2025517969 A2025-06-128618P20827Espacenet
JP 2025517970 A2025-06-128452P20827Espacenet
JP 2025028160 A2025-02-284582P20827Espacenet

1 to 10 of 64

See all 64 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,100

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEFNA1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA030199Cancer Center Support Grant (CCSG)112025
P30CA068485Cancer Center Support Grant82025
I01BX000134Targeting mTORC2 in lung squamous cancer62025
P30CA012197Cancer Center Support Grant62025
T32CA009592Microenvironmental Influences in Cancer62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
R01GM131374Eph Receptor Heterointeractions in Signaling52025
T32CA101642Training of Academic Gynecologic Oncologists52025
P30AR075049Northwestern University Skin Biology and Diseases Resource-based Center42025

1 to 10 of 1,100Source NIH's project files

See all 1,100 nih grants

Papers1,708

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Evidence-based treatment strategies for hypoplastic left heart syndrome: The role of EFNA1/EphA.Ann Pediatr Cardiol202642819669PubTator, text miningPubMed
Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation.EBioMedicine202642771993PubTator, text miningPubMed
Genome-wide association study of estimated glomerular filtration rate using repeated measurements in the Taiwan Biobank.Kidney Res Clin Pract202642711253PubTator, text miningPubMed
Corrigendum to Super-enhancer-driven EFNA1 fuels tumor progression in cervical cancer via the FOSL2-Src/AKT/STAT3 axis.J Clin Invest202642544586PubTator, text miningPubMed
SHED-Exo delivery of miR-708-5p activates PI3K/AKT signaling pathway to alleviate glucocorticoid-induced osteogenic inhibition in BMSCs.Mol Cell Biochem202642461469PubTator, text miningPubMed
Plasma proteomics based on machine learning predict the early risk of kidney outcomes in patients with DKD: a prospective cohort study from UK Biobank.Front Nephrol202642445298PubTator, text miningPubMed
Proteolytic EphA2 fragments cooperatively promote hepatocellular carcinoma progression.Cell Death Dis202642366206PubTator, text miningPubMed
Single-cell and spatial transcriptomics reveal lactate-active epithelial-immune cell crosstalk that reprograms the immune microenvironment in colorectal cancer.Transl Oncol202642320170PubTator, text miningPubMed
Corrigendum to "Cross-species single-cell and spatial transcriptomic mapping reveals EFNA1-EPHA4-mediated stem-like epithelial-macrophage crosstalk driving colorectal cancer progression" [Cancer Letters 649 (2026) 218495].
Cancer Lett202642285780PubTator, text miningPubMed
Comprehensive multi-omics analysis reveals prognostic, immune, and therapeutic signatures of TNFAIP family genes in breast cancer.PLoS One202642213680PubTator, text miningPubMed

1 to 10 of 1,708

See all 1,708 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1942

GET https://conductscience.org/api/genes/v1/1942/patents?page=2