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Gene · 1948

EFNB2: ephrin B2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EFNB2: ephrin B2. Genes, record 1948. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1948

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Gene

Symbol
EFNB2
HGNC
Name
ephrin B2
HGNC
NCBI Gene ID
1948
NCBI Gene
HGNC ID
HGNC:3227
HGNC
Ensembl
ENSG00000125266
NCBI Gene
Aliases
EPLG5, HTKL, Htk-L, LERK5, MGC126226, MGC126227, MGC126228, ephrin-B2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P52799Ephrin-B233310Ensembl, GeneID, HGNC

Source UniProt

Patents91

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12655390 B22026-06-162P52799Espacenet
EP 4650780 A22025-11-1919361P52799Espacenet
JP 2025529142 A2025-09-041363P52799Espacenet
US 12371689 B22025-07-291363P52799Espacenet
JP 2025517970 A2025-06-1219361P52799Espacenet
JP 2025069136 A2025-04-301P52799Espacenet
EP 4511052 A22025-02-2660P52799Espacenet
JP 2024123008 A2024-09-106007P52799Espacenet
JP 2023514611 A2023-04-06114P52799Espacenet
US 11591576 B22023-02-28114P52799Espacenet

1 to 10 of 91

See all 91 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
SEPHB4-HSACHEMBL4298079Ephrin-B2 inhibitorINHIBITOR

Source ChEMBL

Trials13

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04486781SEPHB4-HSAPHASE2ClinicalTrials.gov
NCT04091867SEPHB4-HSAPHASE1ClinicalTrials.gov
NCT04033432SEPHB4-HSAPHASE22022-04-27ClinicalTrials.gov
NCT03993106SEPHB4-HSAPHASE2ClinicalTrials.gov
NCT03552796SEPHB4-HSAPHASE1ClinicalTrials.gov
NCT03519984SEPHB4-HSAPHASE1ClinicalTrials.gov
NCT03146871SEPHB4-HSAPHASE2ClinicalTrials.gov
NCT03049618SEPHB4-HSAPHASE22025-10-22ClinicalTrials.gov
NCT02799485SEPHB4-HSAPHASE2ClinicalTrials.gov
NCT02767921SEPHB4-HSAPHASE1ClinicalTrials.gov

1 to 10 of 13

See all 13 trials

NIH grants1,967

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEFNB2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA046934University of Colorado Cancer Center Support Grant92025
R01DA022727Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)92025
R01DE028529Tackling Treg mediated resistance to radiation and anti-PDL1 in HNSCC's82025
T32AI007647Training Program in Mechanisms of Virus-Host Interactions72025
ZIASC010355Angiogenesis and Tumor Growth72025
P30CA016042Cancer Center Support Grant62025
UL1TR001863Yale Clinical and Translational Science Award62025
ZIABC010782Study of the Roles of SDF1 and CXCR4 in Hematopoiesis62025
K12CA086913Paul Calabresi Award in Clinical Oncology Research52025

1 to 10 of 1,967Source NIH's project files

See all 1,967 nih grants

Papers2,853

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of Quercetin as a Potential Entry Inhibitor of Nipah Virus: A Path Toward Antiviral Therapy.Int J Mol Sci202642794455PubTator, text miningPubMed
Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease.Ann Clin Transl Neurol202642754972PubTator, text miningPubMed
Nipah virus in the era of global connectivity: molecular evolution, transmission risk, and preparedness strategies.Virus Genes202642732490PubTator, text miningPubMed
Discovery of Sennoside A as a Natural O-GlcNAcase Inhibitor That Ameliorates Parkinson's Disease by Restoring EphrinB2 O-GlcNAcylation.Research (Wash D C)202642718897PubTator, text miningPubMed
Macrophages Drive Ferroptosis Resistance after Radiotherapy.Cancer Commun (Lond)202642698964PubTator, text miningPubMed
Role of Arteriogenesis Mechanism in the Remodeling of Choke Vessels in Delayed Multiterritory Perforator Flaps: A Protein-Based Perspective.Ann Plast Surg202642554444PubTator, text miningPubMed
New insight into RNA biomarkers in neuropathic pain: a clinician-neuroscientist roadmap to translational testing and treatment monitoring a clinical review.Front Pain Res (Lausanne)202642534835PubTator, text miningPubMed
Ensemble Docking, MD, and MM/PBSA Identify Flavonoids as Putative Modulators of EFNB2/B3-Nipah Virus G Interaction.Int J Mol Sci202642511483PubTator, text miningPubMed
The extracellular matrix in selective decussation of retinal ganglion cell axons: β2 laminins regulate the ipsilateral projection.Dev Biol202642480735PubTator, text miningPubMed
Identification and analysis of EphrinB2/EphB4 signaling pathway and angiogenesis related biomarkers in coronary artery disease based on bioinformatics.J Cardiothorac Surg202642477815PubTator, text miningPubMed

1 to 10 of 2,853

See all 2,853 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1948

GET https://conductscience.org/api/genes/v1/1948/patents?page=2