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EGFR: epidermal growth factor receptor

1 protein, 880 patents, 90 drugs, 3,844 trials, 34,457 NIH grants and 188,666 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEGFRHGNC
Nameepidermal growth factor receptorHGNC
NCBI Gene ID1956NCBI Gene
HGNC IDHGNC:3236HGNC
EnsemblENSG00000146648NCBI Gene
AliasesERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS, PIG61, mENANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00533Epidermal growth factor receptor1,210388Ensembl, GeneID, HGNCUniProt

Patents 880

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4830734 A12026-10-2823P00533Espacenet
EP 4825380 A12026-10-211P00533Espacenet
JP 2026125612 A2026-08-032P00533Espacenet
JP 2026120541 A2026-07-2235P00533Espacenet
EP 4774000 A12026-07-153P00533Espacenet
EP 4774287 A12026-07-151P00533Espacenet
WO 2026121966 A22026-06-112P00533Espacenet
JP 2026517715 A2026-06-0254P00533Espacenet
US 12636345 B22026-05-2660P00533Espacenet
JP 2026082857 A2026-05-1935P00533Espacenet

Drugs 90

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABIVERTINIBCHEMBL4297865Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
ABIVERTINIB MALEATECHEMBL4297866Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AC-480CHEMBL1645462Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AEE-788CHEMBL587723Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AFATINIBCHEMBL1173655Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AFATINIB DIMALEATECHEMBL2105712Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
ALLITINIBCHEMBL1947204Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AMIVANTAMABCHEMBL4297774Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AUMOLERTINIBCHEMBL4761468Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL
AV-412CHEMBL6067986Epidermal growth factor receptor erbB1 inhibitorINHIBITORChEMBL

Trials 3844

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603791OSIMERTINIBPHASE2ClinicalTrials.gov
NCT07601737NIMOTUZUMABPHASE2ClinicalTrials.gov
NCT07601399CLN-081ClinicalTrials.gov
NCT07595276CETUXIMABPHASE3ClinicalTrials.gov
NCT07586202AMIVANTAMABPHASE2ClinicalTrials.gov
NCT07586202LAZERTINIBPHASE2ClinicalTrials.gov
NCT07581912CETUXIMABPHASE2ClinicalTrials.gov
NCT07581626CETUXIMABPHASE2ClinicalTrials.gov
NCT07559760CETUXIMABPHASE2ClinicalTrials.gov
NCT07554859CETUXIMABPHASE2ClinicalTrials.gov

NIH grants 34457

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1,6882,025NIH's project files
P30CA008748Cancer Center Support Grant1,4162,025NIH's project files
P30CA006973Regional Oncology Research Center2862,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant2782,025NIH's project files
P30CA068485Cancer Center Support Grant2632,025NIH's project files
P30CA016058Cancer Center Support Grant2232,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant2192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award2172,025NIH's project files
P30CA047904Cancer Center Support Grant1902,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase1812,025NIH's project files

Papers 188666

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826900PubTator, text miningPubMed
42826097PubTator, text miningPubMed
42825974PubTator, text miningPubMed
42825943PubTator, text miningPubMed
42824982PubTator, text miningPubMed
42824853PubTator, text miningPubMed
42824774PubTator, text miningPubMed
42823821PubTator, text miningPubMed
42823758PubTator, text miningPubMed
42823535PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license