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Gene · 1959

EGR2: early growth response 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EGR2: early growth response 2. Genes, record 1959. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1959

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Gene

Symbol
EGR2
HGNC
Name
early growth response 2
HGNC
NCBI Gene ID
1959
NCBI Gene
HGNC ID
HGNC:3239
HGNC
Ensembl
ENSG00000122877
NCBI Gene
Aliases
AT591, CMT1D, CMT4E, KROX20
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P11161E3 SUMO-protein ligase EGR24760Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444650P11161Espacenet
JP 2026004568 A2026-01-1444653P11161Espacenet
EP 4641201 A22025-10-29746P11161Espacenet
EP 4641202 A22025-10-294410P11161Espacenet
JP 2025147176 A2025-10-0614918P11161Espacenet
JP 2025517969 A2025-06-12746P11161Espacenet
JP 2025028160 A2025-02-2814918P11161Espacenet
KR 1020250017231 A2025-02-044410P11161Espacenet
KR 1020250010750 A2025-01-2114918P11161Espacenet
WO 2024252368 A22024-12-1232P11161Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,415

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEGR2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
R01MH084894Function of GPCR heteromeric complexes in brain62025
P30CA010815Consolidated Basic Cancer Research Program52025
P01AI102853Molecular Basis for γδ T Lineage Specification42025
P30CA016058Cancer Center Support Grant42025
P30CA016087Cancer Center Support Grant42025
P30CA033572Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025

1 to 10 of 2,415Source NIH's project files

See all 2,415 nih grants

Papers3,476

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Reproducible Transcriptomic Program of Neurofibroma-to-Malignant Peripheral Nerve Sheath Tumor Transformation.Genes Chromosomes Cancer202642765715PubTator, text miningPubMed
CpG content contributes to tissue-resident macrophage enhancer selection.Nucleic Acids Res202642635130PubTator, text miningPubMed
Identification of EGR2 and TGFB1 as Potential Immunoregulatory Biomarkers for Allergic Rhinitis: An Exploratory Bioinformatics and Pilot Validation Study.Med Sci Monit202642543752PubTator, text miningPubMed
EGR2 promotes vascular smooth muscle cell differentiation and proliferation in outward remodeling during arteriovenous fistula maturation.Biochim Biophys Acta Mol Basis Dis202642526818PubTator, text miningPubMed
Integrated 5-HT2A-TrkB and G protein signaling in serotonergic psychedelic responses.Mol Psychiatry202642463904PubTator, text miningPubMed
MAP1S limits autoimmune uveitis by suppressing Th17 differentiation through dual Control of the EGR2-LCN2 axis and autophagic flux.Autophagy202642454709PubTator, text miningPubMed
Abnormal Expression of has-miR-664b-5p in Allergic Rhinitis and Its Possible Impact on the Progression of the Disease.Am J Rhinol Allergy202642434913PubTator, text miningPubMed
Synthesis and Development of Novel Small-Molecule MEIS2 Inhibitors That Induce Cell Death in Breast Cancer Cells by Targeting the Homeobox Domain.Pharmaceuticals (Basel)202642356499PubTator, text miningPubMed
Study on diagnostic genes and immune microenvironment disorder in comorbid atherosclerosis and Alzheimer disease.Medicine (Baltimore)202642332537PubTator, text miningPubMed
Stearoyl-CoA desaturase 5 (SCD5) in lipid remodeling: From molecular control to pathophysiology.J Lipid Res202642285304PubTator, text miningPubMed

1 to 10 of 3,476

See all 3,476 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1959

GET https://conductscience.org/api/genes/v1/1959/patents?page=2