Gene · 1965
EIF2S1: eukaryotic translation initiation factor 2 subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EIF2S1: eukaryotic translation initiation factor 2 subunit alpha. Genes, record 1965. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1965
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P05198 | Eukaryotic translation initiation factor 2 subunit 1 | 315 | 38 | Ensembl, GeneID, HGNC |
Source UniProt
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 1573 | P05198 | Espacenet |
| JP 2025532979 A | 2025-10-03 | 64 | P05198 | Espacenet |
| EP 4593850 A2 | 2025-08-06 | 64 | P05198 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1573 | P05198 | Espacenet |
| US 12295971 B2 | 2025-05-13 | 64 | P05198 | Espacenet |
| US 11865184 B2 | 2024-01-09 | 31 | P05198 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 4846 | P05198 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 8234 | P05198 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28617 | P05198 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28618 | P05198 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,808
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EIF2S1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 17 | 2025 |
| ZIAHD001010 | Mechanism and Regulation of Eukaryotic Protein Synthesis | 12 | 2025 |
| ZIAHD001004 | Molecular Mechanisms of Translational Control | 10 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 8 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| P30CA082709 | Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant | 7 | 2025 |
| R01DK060596 | Translational control by nutrients | 7 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,808Source NIH's project files
See all 2,808 nih grantsPapers3,976
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Insights into molecular mechanisms of poxvirus evolution and host range through studies of poxvirus inhibitors of protein kinase R. | J Virol | 2026 | 42788731 | PubTator, text mining | PubMed |
| Persistent Airway Uric Acid is Associated with Epithelial Stress Signaling and Macrophage Inflammatory Activation in COPD. | J Inflamm Res | 2026 | 42751184 | PubTator, text mining | PubMed |
| Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis. | Ann Clin Transl Neurol | 2026 | 42675804 | PubTator, text mining | PubMed |
| Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma. | Cell Death Dis | 2026 | 42675041 | PubTator, text mining | PubMed |
| EIF2S1-PELO co-expression architecture in human brain: pairing-family decomposition reveals constitutive transcriptional coupling and functional layer separation. | Front Mol Neurosci | 2026 | 42639115 | PubTator, text mining | PubMed |
| Dual relevance of EIF2S1 in acute myeloid leukemia: linking poor prognosis to immune-metabolic states and leukemic cell fitness. | Front Oncol | 2026 | 42620389 | PubTator, text mining | PubMed |
| Inhibition of mitochondrial protein translation sensitizes tumor cells to death receptor 5 agonistic antibody. | FEBS J | 2026 | 42528096 | PubTator, text mining | PubMed |
| Trifluoperazine exhibits broad-spectrum antiviral activity against arboviruses. | Antimicrob Agents Chemother | 2026 | 42489647 | PubTator, text mining | PubMed |
| HRI Kinase Modulation by BTdCPU as a Therapeutic Strategy for Bortezomib Resistance in Prostate Cancer. | Curr Med Chem | 2026 | 42393886 | PubTator, text mining | PubMed |
| Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis. | Genes (Basel) | 2026 | 42353855 | PubTator, text mining | PubMed |
1 to 10 of 3,976
See all 3,976 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1965
GET https://conductscience.org/api/genes/v1/1965/patents?page=2