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Gene · 1965

EIF2S1: eukaryotic translation initiation factor 2 subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF2S1: eukaryotic translation initiation factor 2 subunit alpha. Genes, record 1965. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1965

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Gene

Symbol
EIF2S1
HGNC
Name
eukaryotic translation initiation factor 2 subunit alpha
HGNC
NCBI Gene ID
1965
NCBI Gene
HGNC ID
HGNC:3265
HGNC
Ensembl
ENSG00000134001
NCBI Gene
Aliases
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05198Eukaryotic translation initiation factor 2 subunit 131538Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191573P05198Espacenet
JP 2025532979 A2025-10-0364P05198Espacenet
EP 4593850 A22025-08-0664P05198Espacenet
JP 2025517970 A2025-06-121573P05198Espacenet
US 12295971 B22025-05-1364P05198Espacenet
US 11865184 B22024-01-0931P05198Espacenet
US 11564998 B22023-01-314846P05198Espacenet
US 11564998 B22023-01-318234P05198Espacenet
US 11446398 B22022-09-2028617P05198Espacenet
US 11446398 B22022-09-2028618P05198Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,808

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF2S1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
ZIAHD001010Mechanism and Regulation of Eukaryotic Protein Synthesis122025
ZIAHD001004Molecular Mechanisms of Translational Control102025
P30CA016058Cancer Center Support Grant82025
P30ES006694Southwest Environmental Health Sciences Center82025
UL1TR001863Yale Clinical and Translational Science Award82025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant72025
R01DK060596Translational control by nutrients72025
P30CA015704Cancer Center Support Grant62025
P30CA016086Cancer Center Support Grant62025

1 to 10 of 2,808Source NIH's project files

See all 2,808 nih grants

Papers3,976

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Insights into molecular mechanisms of poxvirus evolution and host range through studies of poxvirus inhibitors of protein kinase R.J Virol202642788731PubTator, text miningPubMed
Persistent Airway Uric Acid is Associated with Epithelial Stress Signaling and Macrophage Inflammatory Activation in COPD.J Inflamm Res202642751184PubTator, text miningPubMed
Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis.Ann Clin Transl Neurol202642675804PubTator, text miningPubMed
Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma.Cell Death Dis202642675041PubTator, text miningPubMed
EIF2S1-PELO co-expression architecture in human brain: pairing-family decomposition reveals constitutive transcriptional coupling and functional layer separation.Front Mol Neurosci202642639115PubTator, text miningPubMed
Dual relevance of EIF2S1 in acute myeloid leukemia: linking poor prognosis to immune-metabolic states and leukemic cell fitness.Front Oncol202642620389PubTator, text miningPubMed
Inhibition of mitochondrial protein translation sensitizes tumor cells to death receptor 5 agonistic antibody.FEBS J202642528096PubTator, text miningPubMed
Trifluoperazine exhibits broad-spectrum antiviral activity against arboviruses.Antimicrob Agents Chemother202642489647PubTator, text miningPubMed
HRI Kinase Modulation by BTdCPU as a Therapeutic Strategy for Bortezomib Resistance in Prostate Cancer.Curr Med Chem202642393886PubTator, text miningPubMed
Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis.Genes (Basel)202642353855PubTator, text miningPubMed

1 to 10 of 3,976

See all 3,976 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1965

GET https://conductscience.org/api/genes/v1/1965/patents?page=2