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EPHA2: EPH receptor A2

1 protein, 232 patents, 3 drugs, 561 trials, 2,921 NIH grants and 5,487 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEPHA2HGNC
NameEPH receptor A2HGNC
NCBI Gene ID1969NCBI Gene
HGNC IDHGNC:3386HGNC
EnsemblENSG00000142627NCBI Gene
AliasesARCC2, CTPA, CTPP1, CTRCT6, ECKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29317Ephrin type-A receptor 2976103Ensembl, GeneID, HGNCUniProt

Patents 232

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12636345 B22026-05-2652P29317Espacenet
JP 2026510354 A2026-04-021P29317Espacenet
JP 2026004432 A2026-01-1433P29317Espacenet
JP 2026004568 A2026-01-1445078P29317Espacenet
US 12514926 B22026-01-0633P29317Espacenet
EP 4650780 A22025-11-197547P29317Espacenet
EP 4641201 A22025-10-297554P29317Espacenet
JP 2025532954 A2025-10-03276P29317Espacenet
JP 2025532958 A2025-10-03276P29317Espacenet
JP 2025529142 A2025-09-041413P29317Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DASATINIB ANHYDROUSCHEMBL1421Ephrin type-A receptor 2 inhibitorINHIBITORChEMBL
REGORAFENIBCHEMBL1946170Ephrin type-A receptor 2 inhibitorINHIBITORChEMBL
VANDETANIBCHEMBL24828Ephrin receptor inhibitorINHIBITORChEMBL

Trials 561

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07463248REGORAFENIBPHASE2ClinicalTrials.gov
NCT07379047REGORAFENIBPHASE2/PHASE3ClinicalTrials.gov
NCT07343791REGORAFENIBEARLY_PHASE1ClinicalTrials.gov
NCT07328009REGORAFENIBPHASE2ClinicalTrials.gov

NIH grants 2921

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant702,025NIH's project files
P30CA008748Cancer Center Support Grant232,025NIH's project files
P30CA068485Cancer Center Support Grant212,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)152,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center152,025NIH's project files
T32CA101642Training of Academic Gynecologic Oncologists152,025NIH's project files
P30CA047904Cancer Center Support Grant142,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant142,025NIH's project files
T32CA009592Microenvironmental Influences in Cancer142,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant132,025NIH's project files

Papers 5487

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816201PubTator, text miningPubMed
42790107PubTator, text miningPubMed
42782943PubTator, text miningPubMed
42778943PubTator, text miningPubMed
42771518PubTator, text miningPubMed
42766031PubTator, text miningPubMed
42760270PubTator, text miningPubMed
42752088PubTator, text miningPubMed
42751639PubTator, text miningPubMed
42709684PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license