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Gene · 197259

MLKL: mixed lineage kinase domain like pseudokinase

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. MLKL: mixed lineage kinase domain like pseudokinase. Genes, record 197259. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/197259

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
MLKL
HGNC
Name
mixed lineage kinase domain like pseudokinase
HGNC
NCBI Gene ID
197259
NCBI Gene
HGNC ID
HGNC:26617
HGNC
Ensembl
ENSG00000168404
NCBI Gene
Aliases
FLJ34389, hMLKL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8NB16Mixed lineage kinase domain-like protein47122Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194550Q8NB16Espacenet
WO 2025163184 A12025-08-072Q8NB16Espacenet
JP 2025517970 A2025-06-124550Q8NB16Espacenet
JP 2025516241 A2025-05-27104Q8NB16Espacenet
KR 1020250067241 A2025-05-156Q8NB16Espacenet
EP 4514822 A22025-03-05104Q8NB16Espacenet
JP 2025024198 A2025-02-1913793Q8NB16Espacenet
JP 2024503623 A2024-01-26104Q8NB16Espacenet
KR 1020230143141 A2023-10-11104Q8NB16Espacenet
JP 2023528300 A2023-07-04122Q8NB16Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,687

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01AI124346Innate immune signaling and stress response312025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation292025
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer242025
R37AI044828Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension212025
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases152025
R35CA231620MECHANISMS OF REGULATED CELL DEATH142025
P30CA006927Comprehensive Cancer Center Program at Fox Chase112025
P30CA021765Cancer Center Support Grant (CCSG)92025
P50AA024333Alcohol and tissue injury, from mechanisms to treatments92025
ZIASC010376TNF Signaling, Cell Death and Cancer92025

1 to 10 of 1,687Source NIH's project files

See all 1,687 nih grants

Papers4,562

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826385PubTator, text miningPubMed
42818015PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42810779PubTator, text miningPubMed
42808676PubTator, text miningPubMed
42806174PubTator, text miningPubMed
42794787PubTator, text miningPubMed
42782792PubTator, text miningPubMed
42781720PubTator, text miningPubMed
42778061PubTator, text miningPubMed

1 to 10 of 4,562

See all 4,562 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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