Gene · 1973
EIF4A1: eukaryotic translation initiation factor 4A1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EIF4A1: eukaryotic translation initiation factor 4A1. Genes, record 1973. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1973
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P60842 | Eukaryotic initiation factor 4A-I | 406 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents74
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 45544 | P60842 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4718 | P60842 | Espacenet |
| US 12433933 B2 | 2025-10-07 | 5 | P60842 | Espacenet |
| EP 4519435 A2 | 2025-03-12 | 36 | P60842 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4718 | P60842 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1515 | P60842 | Espacenet |
| US 11771740 B2 | 2023-10-03 | 5 | P60842 | Espacenet |
| US 11459613 B2 | 2022-10-04 | 28 | P60842 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28832 | P60842 | Espacenet |
| JP 2022533303 A | 2022-07-22 | 5 | P60842 | Espacenet |
1 to 10 of 74
See all 74 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,290
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EIF4A1 papers | Newest fiscal year |
|---|---|---|---|
| R35GM118173 | Chemical Synthesis of Complex Natural Products for Translational Science | 21 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA240139 | The Sylvester Cancer Center Support Grant | 5 | 2025 |
| ZIAHD001004 | Molecular Mechanisms of Translational Control | 5 | 2025 |
| P01CA125066 | Discovery of Anticancer Agents of Diverse Natural Origin | 4 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30CA134274 | UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT | 4 | 2025 |
1 to 10 of 1,290Source NIH's project files
See all 1,290 nih grantsPapers1,962
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| An Investigation to Study Morphology, Nanomechanical Attributes, Transcriptomics, and Proteomics of Tumor Associated Macrophages Derived Extracellular Vesicles in the Tumor Microenvironment. | J Anal Oncol | 2026 | 42719843 | PubTator, text mining | PubMed |
| A Dual-Color Electrophoretic Mobility Shift Assay to Examine RNA-Binding and RNA Chaperone Activity Simultaneously. | Methods Mol Biol | 2026 | 42681196 | PubTator, text mining | PubMed |
| A Dimeric Protein-RNA Glue Promotes Multivalent eIF4A-RNA Assembly. | ACS Cent Sci | 2026 | 42666664 | PubTator, text mining | PubMed |
| eIF4A1 enhances p70S6K mRNA translation and promotes nuclear β-catenin levels to augment stemness and metastasis in gastric cancer cells. | Biochem Pharmacol | 2026 | 42628754 | PubTator, text mining | PubMed |
| Paediatric therapeutic development workshop on osteosarcoma. | Br J Cancer | 2026 | 42613365 | PubTator, text mining | PubMed |
| High-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Alterations in Acral Melanoma. | Mol Cell Proteomics | 2026 | 42442611 | PubTator, text mining | PubMed |
| Correction: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells. | Elife | 2026 | 42307616 | PubTator, text mining | PubMed |
| A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth. | Cell Rep | 2026 | 42201810 | PubTator, text mining | PubMed |
| Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer. | Mol Cancer | 2026 | 42163342 | PubTator, text mining | PubMed |
| Surfactant Protein B Precursor Inhibit the Progression of Resectable Non-small Cell Lung Cancer by Suppressing eIF4F-mediated Immune Evasion and Cancer Stemness. | Int J Biol Sci | 2026 | 42157944 | PubTator, text mining | PubMed |
1 to 10 of 1,962
See all 1,962 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1973
GET https://conductscience.org/api/genes/v1/1973/patents?page=2