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Gene · 1973

EIF4A1: eukaryotic translation initiation factor 4A1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF4A1: eukaryotic translation initiation factor 4A1. Genes, record 1973. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1973

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Gene

Symbol
EIF4A1
HGNC
Name
eukaryotic translation initiation factor 4A1
HGNC
NCBI Gene ID
1973
NCBI Gene
HGNC ID
HGNC:3282
HGNC
Ensembl
ENSG00000161960
NCBI Gene
Aliases
DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P60842Eukaryotic initiation factor 4A-I40616Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445544P60842Espacenet
EP 4641202 A22025-10-294718P60842Espacenet
US 12433933 B22025-10-075P60842Espacenet
EP 4519435 A22025-03-1236P60842Espacenet
KR 1020250017231 A2025-02-044718P60842Espacenet
US 11860162 B22024-01-021515P60842Espacenet
US 11771740 B22023-10-035P60842Espacenet
US 11459613 B22022-10-0428P60842Espacenet
US 11446398 B22022-09-2028832P60842Espacenet
JP 2022533303 A2022-07-225P60842Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,290

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF4A1 papersNewest fiscal year
R35GM118173Chemical Synthesis of Complex Natural Products for Translational Science212025
P30CA008748Cancer Center Support Grant162025
P30CA016672Cancer Center Support Grant92025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA240139The Sylvester Cancer Center Support Grant52025
ZIAHD001004Molecular Mechanisms of Translational Control52025
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin42025
P30CA013148Comprehensive Cancer Center Support Grant42025
P30CA016058Cancer Center Support Grant42025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT42025

1 to 10 of 1,290Source NIH's project files

See all 1,290 nih grants

Papers1,962

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An Investigation to Study Morphology, Nanomechanical Attributes, Transcriptomics, and Proteomics of Tumor Associated Macrophages Derived Extracellular Vesicles in the Tumor Microenvironment.J Anal Oncol202642719843PubTator, text miningPubMed
A Dual-Color Electrophoretic Mobility Shift Assay to Examine RNA-Binding and RNA Chaperone Activity Simultaneously.Methods Mol Biol202642681196PubTator, text miningPubMed
A Dimeric Protein-RNA Glue Promotes Multivalent eIF4A-RNA Assembly.ACS Cent Sci202642666664PubTator, text miningPubMed
eIF4A1 enhances p70S6K mRNA translation and promotes nuclear β-catenin levels to augment stemness and metastasis in gastric cancer cells.Biochem Pharmacol202642628754PubTator, text miningPubMed
Paediatric therapeutic development workshop on osteosarcoma.Br J Cancer202642613365PubTator, text miningPubMed
High-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Alterations in Acral Melanoma.Mol Cell Proteomics202642442611PubTator, text miningPubMed
Correction: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells.Elife202642307616PubTator, text miningPubMed
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth.Cell Rep202642201810PubTator, text miningPubMed
Increased mRNA translation delays tumour initiation and exposes a therapeutic vulnerability in lung cancer.Mol Cancer202642163342PubTator, text miningPubMed
Surfactant Protein B Precursor Inhibit the Progression of Resectable Non-small Cell Lung Cancer by Suppressing eIF4F-mediated Immune Evasion and Cancer Stemness.Int J Biol Sci202642157944PubTator, text miningPubMed

1 to 10 of 1,962

See all 1,962 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1973

GET https://conductscience.org/api/genes/v1/1973/patents?page=2