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Gene · 1974

EIF4A2: eukaryotic translation initiation factor 4A2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF4A2: eukaryotic translation initiation factor 4A2. Genes, record 1974. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1974

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Gene

Symbol
EIF4A2
HGNC
Name
eukaryotic translation initiation factor 4A2
HGNC
NCBI Gene ID
1974
NCBI Gene
HGNC ID
HGNC:3284
HGNC
Ensembl
ENSG00000156976
NCBI Gene
Aliases
BM-010, DDX2B, EIF4A, EIF4F, NEDHSS, eIF-4A-II, eIF4A-II
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14240Eukaryotic initiation factor 4A-II4071Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445548Q14240Espacenet
EP 4650780 A22025-11-195661Q14240Espacenet
EP 4641201 A22025-10-295314Q14240Espacenet
JP 2025517969 A2025-06-125314Q14240Espacenet
JP 2025517970 A2025-06-125661Q14240Espacenet
US 11446398 B22022-09-2028852Q14240Espacenet
JP 2022524081 A2022-04-27131823Q14240Espacenet
US 11078247 B22021-08-033473Q14240Espacenet
JP 2019054813 A2019-04-11225983Q14240Espacenet
EP 3394291 A12018-10-31221Q14240Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,193

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF4A2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant242025
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin152025
R35GM118173Chemical Synthesis of Complex Natural Products for Translational Science152025
P30CA016058Cancer Center Support Grant112025
ZIAHD001004Molecular Mechanisms of Translational Control102025
R35GM122602Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality control92025
P30CA016672Cancer Center Support Grant82025
P30CA062203Cancer Center Support Grant72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025
R01GM056927Control of Translation in Herpesvirus Infected Cells - Resubmission - 172025

1 to 10 of 2,193Source NIH's project files

See all 2,193 nih grants

Papers3,023

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Dimeric Protein-RNA Glue Promotes Multivalent eIF4A-RNA Assembly.ACS Cent Sci202642666664PubTator, text miningPubMed
Poly(A)-binding proteins in trypanosomatids and Plasmodium.J Biosci202642615421PubTator, text miningPubMed
Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy.EMBO Mol Med202642477455PubTator, text miningPubMed
Single-cell and spatial omics reveals region-specific plasticity and therapeutic vulnerabilities in metastatic high-risk neuroblastoma.Sci Adv202642467756PubTator, text miningPubMed
Molecular Feasibility of Gene Sequencing on Lymph Node Fine-Needle Cytology Samples of Non-Hodgkin Lymphoma.Int J Mol Sci202642450228PubTator, text miningPubMed
40S ribosomal subunits move along the 5' UTR through an eIF4A-independent mechanism in higher eukaryotes.bioRxiv202642395458PubTator, text miningPubMed
Remodeling of mRNA by eIF4F in human translation initiation.bioRxiv202642367976PubTator, text miningPubMed
Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis.Elife202642345371PubTator, text miningPubMed
Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation.Extracell Vesicle202642344609PubTator, text miningPubMed
Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer.Cell Rep202642284146PubTator, text miningPubMed

1 to 10 of 3,023

See all 3,023 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1974

GET https://conductscience.org/api/genes/v1/1974/patents?page=2