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Gene · 1975

EIF4B: eukaryotic translation initiation factor 4B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF4B: eukaryotic translation initiation factor 4B. Genes, record 1975. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1975

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Gene

Symbol
EIF4B
HGNC
Name
eukaryotic translation initiation factor 4B
HGNC
NCBI Gene ID
1975
NCBI Gene
HGNC ID
HGNC:3285
HGNC
Ensembl
ENSG00000063046
NCBI Gene
Aliases
EIF-4B, PRO1843
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23588Eukaryotic translation initiation factor 4B6113Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192006P23588Espacenet
JP 2025517970 A2025-06-122006P23588Espacenet
JP 2024123008 A2024-09-106100P23588Espacenet
US 11446398 B22022-09-2028863P23588Espacenet
US 11366100 B22022-06-2122P23588Espacenet
JP 2022524081 A2022-04-27131834P23588Espacenet
US 11078247 B22021-08-033475P23588Espacenet
WO 2020043864 A12020-03-051183P23588Espacenet
US 10501513 B22019-12-106100P23588Espacenet
US 10254283 B22019-04-0922P23588Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,316

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF4B papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
ZIAHD001004Molecular Mechanisms of Translational Control92025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025
R35GM122602Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality control62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA062203Cancer Center Support Grant42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025

1 to 10 of 1,316Source NIH's project files

See all 1,316 nih grants

Papers2,047

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting PIM kinases in cancer and inflammatory disorders: From mechanisms to clinical translation.Eur J Med Chem202642822254PubTator, text miningPubMed
PTBP1-Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop.Adv Sci (Weinh)202642801686PubTator, text miningPubMed
Poly(A)-binding proteins in trypanosomatids and Plasmodium.J Biosci202642615421PubTator, text miningPubMed
Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation.Adv Sci (Weinh)202642489286PubTator, text miningPubMed
Dynamic redistribution of eIF4F controls cap-dependent translation initiation.bioRxiv202642395578PubTator, text miningPubMed
Retinoic acid is a translation inhibitor against chikungunya virus both in vitro and invivo.Virol Sin202642392364PubTator, text miningPubMed
Nanometer-scale RNA protein clusters (RPCs) Foster Helicase Activity of DEAD-box eIF4A.bioRxiv202642244568PubTator, text miningPubMed
Advancements in single-molecule fluorescence spectroscopy for probing conformations, dynamics, and interactions in disordered protein regions.Curr Opin Struct Biol202642172735PubTator, text miningPubMed
Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes.PLoS One202641855213PubTator, text miningPubMed
Longitudinal multi-omics profiling of spinal muscular atrophy.Neurotherapeutics202641825231PubTator, text miningPubMed

1 to 10 of 2,047

See all 2,047 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1975

GET https://conductscience.org/api/genes/v1/1975/patents?page=2