Gene · 1975
EIF4B: eukaryotic translation initiation factor 4B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EIF4B: eukaryotic translation initiation factor 4B. Genes, record 1975. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1975
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P23588 | Eukaryotic translation initiation factor 4B | 611 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2006 | P23588 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2006 | P23588 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6100 | P23588 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28863 | P23588 | Espacenet |
| US 11366100 B2 | 2022-06-21 | 22 | P23588 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 131834 | P23588 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3475 | P23588 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1183 | P23588 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 6100 | P23588 | Espacenet |
| US 10254283 B2 | 2019-04-09 | 22 | P23588 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,316
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EIF4B papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| ZIAHD001004 | Molecular Mechanisms of Translational Control | 9 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 6 | 2025 |
| R35GM122602 | Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality control | 6 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 4 | 2025 |
1 to 10 of 1,316Source NIH's project files
See all 1,316 nih grantsPapers2,047
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting PIM kinases in cancer and inflammatory disorders: From mechanisms to clinical translation. | Eur J Med Chem | 2026 | 42822254 | PubTator, text mining | PubMed |
| PTBP1-Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop. | Adv Sci (Weinh) | 2026 | 42801686 | PubTator, text mining | PubMed |
| Poly(A)-binding proteins in trypanosomatids and Plasmodium. | J Biosci | 2026 | 42615421 | PubTator, text mining | PubMed |
| Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation. | Adv Sci (Weinh) | 2026 | 42489286 | PubTator, text mining | PubMed |
| Dynamic redistribution of eIF4F controls cap-dependent translation initiation. | bioRxiv | 2026 | 42395578 | PubTator, text mining | PubMed |
| Retinoic acid is a translation inhibitor against chikungunya virus both in vitro and invivo. | Virol Sin | 2026 | 42392364 | PubTator, text mining | PubMed |
| Nanometer-scale RNA protein clusters (RPCs) Foster Helicase Activity of DEAD-box eIF4A. | bioRxiv | 2026 | 42244568 | PubTator, text mining | PubMed |
| Advancements in single-molecule fluorescence spectroscopy for probing conformations, dynamics, and interactions in disordered protein regions. | Curr Opin Struct Biol | 2026 | 42172735 | PubTator, text mining | PubMed |
| Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes. | PLoS One | 2026 | 41855213 | PubTator, text mining | PubMed |
| Longitudinal multi-omics profiling of spinal muscular atrophy. | Neurotherapeutics | 2026 | 41825231 | PubTator, text mining | PubMed |
1 to 10 of 2,047
See all 2,047 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1975
GET https://conductscience.org/api/genes/v1/1975/patents?page=2